Safety and pharmacokinetics of single doses of (+)-calanolide A, a novel, naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy, human immunodeficiency virus-negative human subjects

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 5, 2001, Pages 1379-1386

  Creagh, T ^a   Ruckle, J L ^a   Tolbert, D T ^a   Giltner, J ^a   Eiznhamer, D A ^a   Dutta, B ^a   Flavin, M T ^a   Xu, Z Q ^a  

^a Sarawak MediChem Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALANOLIDE A;

ADULT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG HALF LIFE; DRUG ISOLATION; DRUG SAFETY; ERUCTATION; FEMALE; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL; VERTIGO;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AREA UNDER CURVE; COHORT STUDIES; COUMARINS; FEMALE; HUMANS; MALE; MIDDLE AGED; PYRANOCOUMARINS; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 0035037065     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.5.1379-1386.2001     Document Type: Article

References (11)

1. Analysis of non-nucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase
2. Unique anti-human immunodeficiency virus activities of the nonnucleoside reverse transcriptase inhibitors calanolide A, costatolide, and dihydrocostatolide
3. Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups
4. Antiviral activity and mechanism of action of (+)-calanolide A against the human immunodeficiency virus type 1
5. Kinetic analysis of inhibition of human immunodeficiency virus Type 1 reverse transcriptase by (+)-calanolide A
6. Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (±)-calanolide A and its enantiomers
7. The (+)-calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum
8. Sensitivity and resistance to (+)-calanolide A of wild type and mutated forms of HIV-1 reverse transcriptase
9. Clinical implications of resistance to antiretroviral drugs
10. Calanolides, the naturally occurring anti-HIV agents
11. Quantification of (+)-calanolide A, a novel and naturally occurring anti-HIV agent, by high-performance liquid chromatography in plasma from rat, dog and human