-
1
-
-
0026030735
-
Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase
-
BABA, M., DECLERCQ, E., TANAKA, H., UBASAWA, M., TAKASHIMA, H., SEKIYA, K., NITTA, I., UMEZU, K., NAKASHIMA, H. AND MORI, S: Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase. Proc. Natl. Acad. Sci U.S.A. 88: 2356-2360, 1991a.
-
(1991)
Proc. Natl. Acad. Sci U.S.A.
, vol.88
, pp. 2356-2360
-
-
Baba, M.1
DeClercq, E.2
Tanaka, H.3
Ubasawa, M.4
Takashima, H.5
Sekiya, K.6
Nitta, I.7
Umezu, K.8
Nakashima, H.9
Mori, S.10
-
2
-
-
0025875711
-
Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives
-
BABA, M., DECLERCQ, E., TANAKA, H., UBASAWA, M., TAKASHIMA, H., SEKIYA, K., NITTA, I., UMEZU, K., WALKER, R. T. AND MORI, S: Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives. Mol. Pharmacol. 39: 805-810, 1991b.
-
(1991)
Mol. Pharmacol.
, vol.39
, pp. 805-810
-
-
Baba, M.1
DeClercq, E.2
Tanaka, H.3
Ubasawa, M.4
Takashima, H.5
Sekiya, K.6
Nitta, I.7
Umezu, K.8
Walker, R.T.9
Mori, S.10
-
3
-
-
0027202617
-
Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-spiro-5″- (4″-amino-1′,2″-oxathiole-2″,2″-dioxide)]-beta-D- pentofuranosyl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors
-
BALZARINI, J., KARLSSON, A., VANDAMME, A. M., PEREZ-PEREZ, M. J., ZHANG, H., VRANG, L., OBERG, B., BACKBRO, K., UNGE, T. AND SAN-FELIX, A.: Human immunodeficiency virus type 1 (HIV-1) strains selected for resistance against the HIV-1-specific [2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-spiro-5″- (4″-amino-1′,2″-oxathiole-2″,2″-dioxide)]-beta-D- pentofuranosyl (TSAO) nucleoside analogues retain sensitivity to HIV-1-specific nonnucleoside inhibitors. Proc. Natl. Acad. Sci. U.S.A. 90: 6952-6956, 1993.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 6952-6956
-
-
Balzarini, J.1
Karlsson, A.2
Vandamme, A.M.3
Perez-Perez, M.J.4
Zhang, H.5
Vrang, L.6
Oberg, B.7
Backbro, K.8
Unge, T.9
San-Felix, A.10
-
4
-
-
0027412181
-
Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase
-
BOYER, P. L., CURRENS, M. J., MCMAHON, J. B., BOYD, M. R. AND HUGHES, S. H.: Analysis of nonnucleoside drug-resistant variants of human immunodeficiency virus type 1 reverse transcriptase. J. Virol. 67: 2412-2420, 1993.
-
(1993)
J. Virol.
, vol.67
, pp. 2412-2420
-
-
Boyer, P.L.1
Currens, M.J.2
Mcmahon, J.B.3
Boyd, M.R.4
Hughes, S.H.5
-
5
-
-
0028024028
-
Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase
-
BOYER, P. L., DING, J., ARNOLD, E. AND HUGHES, S. H.: Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemother. 38: 1909-1914, 1994.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 1909-1914
-
-
Boyer, P.L.1
Ding, J.2
Arnold, E.3
Hughes, S.H.4
-
6
-
-
0028899197
-
Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups
-
BUCKHEIT, R. W., JR, FLIAKAS-BOLTZ, V., DECKER, W. D., ROBERSON, J. L., STUP, T. L., PYLE, C. A., WHITE, E. L., MCMAHON, J. B., CURRENS, M. J., BOYD, M. R. AND BADER, J. P.: Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups. Antiviral Res. 26: 117-132, 1995.
-
(1995)
Antiviral Res.
, vol.26
, pp. 117-132
-
-
Buckheit Jr., R.W.1
Fliakas-Boltz, V.2
Decker, W.D.3
Roberson, J.L.4
Stup, T.L.5
Pyle, C.A.6
White, E.L.7
Mcmahon, J.B.8
Currens, M.J.9
Boyd, M.R.10
Bader, J.P.11
-
7
-
-
0030439224
-
Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus type-1
-
CURRENS, M. J., GULAKOWSKI, R. J., MARINER, J. M., MORAN, R. A., BUCKHEIT, R. W., JR., GUSTAFSON, K. R., MCMAHON, J. B. AND BOYD, M. R.: Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus type-1. J. Pharmacol. Exp. Ther. 279: 645-651, 1996.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.279
, pp. 645-651
-
-
Currens, M.J.1
Gulakowski, R.J.2
Mariner, J.M.3
Moran, R.A.4
Buckheit Jr., R.W.5
Gustafson, K.R.6
Mcmahon, J.B.7
Boyd, M.R.8
-
8
-
-
0027103626
-
Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and-thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase
-
DEBYSER, Z., PAUWELS, R., BABA, M., DESMYTER, J. AND DECLERCQ, E: Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and-thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase. Mol. Pharmacol. 41: 963-968, 1992a.
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 963-968
-
-
Debyser, Z.1
Pauwels, R.2
Baba, M.3
Desmyter, J.4
DeClercq, E.5
-
9
-
-
0026773359
-
Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2′,3′-dideoxynucleoside 5′-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thione, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives
-
DEBYSER, Z., VANDAMME, A. M., PAUWELS, R., BABA, M., DESMYTER, J. AND DE CLERCQ, E.: Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2′,3′-dideoxynucleoside 5′-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thione, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives. J Biol. Chem. 267: 11769-11776, 1992b.
-
(1992)
J Biol. Chem.
, vol.267
, pp. 11769-11776
-
-
Debyser, Z.1
Vandamme, A.M.2
Pauwels, R.3
Baba, M.4
Desmyter, J.5
De Clercq, E.6
-
10
-
-
0026523623
-
HIV inhibitors targeted at the reverse transcriptase
-
DECLERCQ, E: HIV inhibitors targeted at the reverse transcriptase. Aids Res. Hum. Retroviruses 8: 119-134, 1992.
-
(1992)
Aids Res. Hum. Retroviruses
, vol.8
, pp. 119-134
-
-
DeClercq, E.1
-
11
-
-
0028120730
-
HIV resistance to reverse transcriptase inhibitors
-
DECLERCQ, E: HIV resistance to reverse transcriptase inhibitors. Biochem. Pharmacol. 47: 155-169, 1994.
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 155-169
-
-
DeClercq, E.1
-
12
-
-
0026592957
-
The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase
-
DUEWEKE, T. J., KEZDY, F. J., WASZAK, G. A., DEIBEL, M., JR. AND TARPLEY, W. G.: The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase. J Biol. Chem. 267: 27-30, 1992.
-
(1992)
J Biol. Chem.
, vol.267
, pp. 27-30
-
-
Dueweke, T.J.1
Kezdy, F.J.2
Waszak, G.A.3
Deibel Jr., M.4
Tarpley, W.G.5
-
13
-
-
0026003110
-
Pyridinone derivatives: Specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity
-
GOLDMAN, M. E., NUNBERG, J. H., O'BRIEN, J. A., QUINTERO, J. C., SCHLEIF, W. A., FREUND, K. F., GAUL, S. L., SAARI, W. S., WAI, J. S. AND HOFFMAN, J. M.: Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity. Proc Natl. Acad. Sci. U.S.A. 88: 6863-6867, 1991.
-
(1991)
Proc Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 6863-6867
-
-
Goldman, M.E.1
Nunberg, J.H.2
O'Brien, J.A.3
Quintero, J.C.4
Schleif, W.A.5
Freund, K.F.6
Gaul, S.L.7
Saari, W.S.8
Wai, J.S.9
Hoffman, J.M.10
-
14
-
-
0029075643
-
Rational drug design and HIV: Hopes and limitations. Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors
-
GOODY, R. S., RITTINGER, K., DIVITA, G. AND GOODY, R. S.: Rational drug design and HIV: hopes and limitations. Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors. Natl. Med. 1: 519-520, 1995.
-
(1995)
Natl. Med.
, vol.1
, pp. 519-520
-
-
Goody, R.S.1
Rittinger, K.2
And, D.G.3
Goody, R.S.4
-
15
-
-
0027225174
-
Specific inhibition of the reverse transcriptase of human immunodeficiency virus type 1 and the chimeric enzymes of human immunodeficiency virus type 1 and type 2 by nonnucleoside inhibitors
-
HIZI, A., TAL, R., SHAHARABANY, M., CURRENS, M. J., BOYD, M. R., HUGHES, S. H. AND MCMAHON, J. B.: Specific inhibition of the reverse transcriptase of human immunodeficiency virus type 1 and the chimeric enzymes of human immunodeficiency virus type 1 and type 2 by nonnucleoside inhibitors. Antimicrob. Agents Chemother. 37: 1037-1042, 1993.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1037-1042
-
-
Hizi, A.1
Tal, R.2
Shaharabany, M.3
Currens, M.J.4
Boyd, M.R.5
Hughes, S.H.6
Mcmahon, J.B.7
-
16
-
-
0027135357
-
Identification of the amino acid in the human immunodeficiency virus type 1 reverse transcriptase involved in the pyrophosphate binding of antiviral nucleoside triphosphate analogs and phosphonoformate. Implications for multiple drug resistance
-
IM, G. J., TRAMONTANO, E., GONZALEZ, C. J. AND CHENG, Y. C.: Identification of the amino acid in the human immunodeficiency virus type 1 reverse transcriptase involved in the pyrophosphate binding of antiviral nucleoside triphosphate analogs and phosphonoformate. Implications for multiple drug resistance. Biochem. Pharmacol. 46: 2307-2313, 1993.
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 2307-2313
-
-
Im, G.J.1
Tramontano, E.2
Gonzalez, C.J.3
Cheng, Y.C.4
-
17
-
-
0026647540
-
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum
-
published erratum appears in J. Med. Chem. 1993 Apr. 16: 36:1110
-
KASHMAN, Y., GUSTAFSON, K. R., FULLER, R. W., CARDELLINA, J., MCMAHON, J. B., CURRENS, M. J., BUCKHEIT, RWJ, HUGHES, S. H., CRAGG, G. M. AND BOYD, M. R.: The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum [published erratum appears in J. Med. Chem. 1993 Apr. 16: 36:1110]. J. Med. Chem. 35: 2735-2743, 1992.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2735-2743
-
-
Kashman, Y.1
Gustafson, K.R.2
Fuller, R.W.3
Cardellina, J.4
Mcmahon, J.B.5
Currens, M.J.6
Buckheit, R.W.J.7
Hughes, S.H.8
Cragg, G.M.9
Boyd, M.R.10
-
18
-
-
0026579394
-
In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase
-
published erratum appears in Mol. Pharmacol. 1992 Jul 42: 174
-
MELLORS, J. W., DUTSCHMAN, G. E., IM, G. J., TRAMONTANO, E., WINKLER, S. R. AND CHENG, Y. C.: In vitro selection and molecular characterization of human immunodeficiency virus-1 resistant to non-nucleoside inhibitors of reverse transcriptase [published erratum appears in Mol. Pharmacol. 1992 Jul 42: 174]. Mol. Pharmacol. 41: 446-51, 1992.
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 446-451
-
-
Mellors, J.W.1
Dutschman, G.E.2
Im, G.J.3
Tramontano, E.4
Winkler, S.R.5
Cheng, Y.C.6
-
19
-
-
0026077832
-
Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors
-
NUNBERG, J. H., SCHLEIF, W. A., BOOTS, E. J., O'BRIEN, J. A., QUINTERO, J. C., HOFFMAN, J. M., EMINI, E. A. AND GOLDMAN, M. E.: Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors. J. Virol. 65: 4887-4892, 1991.
-
(1991)
J. Virol.
, vol.65
, pp. 4887-4892
-
-
Nunberg, J.H.1
Schleif, W.A.2
Boots, E.J.3
O'Brien, J.A.4
Quintero, J.C.5
Hoffman, J.M.6
Emini, E.A.7
Goldman, M.E.8
-
20
-
-
0026318387
-
Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture
-
RICHMAN, D., SHIH, C. K., LOWY, I., ROSE, J., PRODANOVICH, P., GOFF, S. AND GRIFFIN, J: Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc. Natl. Acad. Sci. U.S.A. 88: 11241-11245, 1991.
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 11241-11245
-
-
Richman, D.1
Shih, C.K.2
Lowy, I.3
Rose, J.4
Prodanovich, P.5
Goff, S.6
Griffin, J.7
-
23
-
-
0023475103
-
3′-Azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase
-
ST. CLAIR, M. H., RICHARDS, C. A., SPECTOR, T., WEINHOLD, K. J., MILLER, W. H., LANGLOIS, A. J. AND FURMAN, P. A.: 3′-Azido-3′-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase. Antimicrob. Agents Chemother. 31: 1972-1977, 1987.
-
(1987)
Antimicrob. Agents Chemother.
, vol.31
, pp. 1972-1977
-
-
St. Clair, M.H.1
Richards, C.A.2
Spector, T.3
Weinhold, K.J.4
Miller, W.H.5
Langlois, A.J.6
Furman, P.A.7
-
24
-
-
0028221241
-
Kinetic and mutational analysis of human immunodeficiency virus type 1 reverse transcriptase inhibition by inophyllums, a novel class of non-nucleoside inhibitors
-
TAYLOR, P. B., CULP, J. S., DEBOUCK, C., JOHNSON, R. K., PATIL, A. D., WOOLF, D. J., BROOKS, I. AND HERTZBERG, R. P.: Kinetic and mutational analysis of human immunodeficiency virus type 1 reverse transcriptase inhibition by inophyllums, a novel class of non-nucleoside inhibitors. J. Biol. Chem. 269: 6325-6331, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 6325-6331
-
-
Taylor, P.B.1
Culp, J.S.2
Debouck, C.3
Johnson, R.K.4
Patil, A.D.5
Woolf, D.J.6
Brooks, I.7
Hertzberg, R.P.8
-
25
-
-
0022555975
-
PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase
-
VRANG, L. AND OBERG, B: PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase. Antimicrob. Agents Chemother. 29: 867-872, 1986.
-
(1986)
Antimicrob. Agents Chemother.
, vol.29
, pp. 867-872
-
-
Vrang, L.1
Oberg, B.2
-
26
-
-
12644292869
-
Rapid generation of AZT-resistant strains of HIV-1 after low-dose therapy and by in vitro selection
-
WAINBERG, M. A., GAO, Q., YAO, X. J., PARNIAK, M. A., FANNING, M., MONTANER, J. S., O'SHAUGHNESSY, M., TSOUKAS, C. AND RUEDY, J: Rapid generation of AZT-resistant strains of HIV-1 after low-dose therapy and by in vitro selection. Int. Conf. AIDS 7: 79, 1991.
-
(1991)
Int. Conf. AIDS
, vol.7
, pp. 79
-
-
Wainberg, M.A.1
Gao, Q.2
Yao, X.J.3
Parniak, M.A.4
Fanning, M.5
Montaner, J.S.6
O'Shaughnessy, M.7
Tsoukas, C.8
Ruedy, J.9
-
27
-
-
12644300599
-
Mechanism of inhibition by carbovir triphosphate of HIV reverse transcriptase and human DNA polymerases, compared with the action of AZT triphosphate and dideoxynucleoside triphosphates
-
WHITE, E. L., SHADDIX, S. C., VINCE, R., SHANNON, W. M. AND PARKER, W. B.: Mechanism of inhibition by carbovir triphosphate of HIV reverse transcriptase and human DNA polymerases, compared with the action of AZT triphosphate and dideoxynucleoside triphosphates. Int. Conf. AIDS 6: 266, 1990.
-
(1990)
Int. Conf. AIDS
, vol.6
, pp. 266
-
-
White, E.L.1
Shaddix, S.C.2
Vince, R.3
Shannon, W.M.4
Parker, W.B.5
-
28
-
-
0000957077
-
Studies on liver alcohol dehydrogenase complexes III. Multiple inhibition kinetics in the presence of two competitive inhibitors
-
YONETANI, T. AND THEORELL, H: Studies on liver alcohol dehydrogenase complexes III. Multiple inhibition kinetics in the presence of two competitive inhibitors. Arch. Biochem. Biophys. 106: 243-251, 1964.
-
(1964)
Arch. Biochem. Biophys.
, vol.106
, pp. 243-251
-
-
Yonetani, T.1
Theorell, H.2
-
29
-
-
0026030735
-
Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase
-
BABA, M., DECLERCQ, E., TANAKA, H., UBASAWA, M., TAKASHIMA, H., SEKIYA, K., NITTA, I., UMEZU, K., NAKASHIMA, H. AND MORI, S: Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase. Proc. Natl. Acad. Sci. U.S.A. 88: 2356-2360, 1991a.
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 2356-2360
-
-
Baba, M.1
DeClercq, E.2
Tanaka, H.3
Ubasawa, M.4
Takashima, H.5
Sekiya, K.6
Nitta, I.7
Umezu, K.8
Nakashima, H.9
Mori, S.10
|