Synthesis and anti-HIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles

Farmaco

Volumn 57, Issue 10, 2002, Pages 819-823

  Rao, Angela ^a   Chimirri, Alba ^a   De Clercq, Erik ^b   Monforte, Anna Maria ^a   Monforte, Pietro ^a   Pannecouque, Christophe ^b   Zappalà, Maria ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

1,2 Substituted benzimidazoles; Anti HIV agents; NNRTI

Indexed keywords

1 (2' FLUOROBENZYL) 2 (2' FLUOROPHENYL)BENZIMIDAZOLE; 1 (2',6' DIFLUOROBENZYL) 2 (2',6' DIFLUOROPHENYL) 5 METHYLBENZIMIDAZOLE; 1 (2',6' DIFLUOROBENZYL) 2 (2',6' DIFLUOROPHENYL) 5,6 DIMETHYLBENZIMIDAZOLE; 1 (2',6' DIFLUOROBENZYL) 2 (2',6' DIFLUOROPHENYL) 6 METHYLBENZIMIDAZOLE; 1 (2',6' DIFLUOROBENZYL) 2 (2',6' DIFLUOROPHENYL)BENZIMIDAZOLE; 1 (2,6 DIFLUOROPHENYL) 1H,3H THIAZOLO[3,4 A]BENZIMIDAZOLE; 1,5 (2' CHLORO 6' FLUOROBENZYL) 2 (2' CHLORO 6' FLUOROPHENYL) 6 METHOXYBENZIMIDAZOLE; 1,5 (2',6' DIFLUOROBENZYL) 2 (2',6' DIFLUOROPHENYL) 6 METHOXYBENZIMIDAZOLE; 1,6 (2' CHLORO 6' FLUOROBENZYL) 2 (2' CHLORO 6' FLUOROPHENYL) 5 METHOXYBENZIMIDAZOLE; 1,6 (2',6' DIFLUOROBENZYL) 2 (2',6' DIFLUOROPHENYL) 5 METHOXYBENZIMIDAZOLE; 6 CARBOXY 1 (2',6' DIFLUOROBENZYL ) 2 (2',6' DIFLUOROPHENYL)BENZIMIDAZOLE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; VIRUS STRAIN; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; LD 50; STRUCTURE ACTIVITY RELATION; SYNTHESIS; VIRUS REPLICATION;

ANTI-HIV AGENTS; BENZIMIDAZOLES; CELL LINE, TRANSFORMED; HIV-1; HIV-2; HUMANS; LETHAL DOSE 50; MODELS, MOLECULAR; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 1842866611     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(02)01300-9     Document Type: Article

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