Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4 (3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Journal of Medicinal Chemistry

Volumn 44, Issue 16, 2001, Pages 2544-2554

  Mai, A ^a   Sbardella, G ^a   Artico, M ^a   Ragno, R ^a   Massa, S ^b   Novellino, E ^c   Greco, G ^c   Lavecchia, A ^c   Musiu, C ^d   La Colla, M ^e   Murgioni, C ^e   La Colla, P ^e   Loddo, R ^e  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d Novirio Pharmaceuticals Inc Boston   (Italy)

^e UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOHEXYLTHIO 3,4 DIHYDRO 6 [1 (1 NAPHTHYL)PROPYL]PYRIMIDIN 4(3H) ONE; 2 CYCLOPENTYLTHIO 3,4 DIHYDRO 6 (1 PHENYL)ETHYLPYRIMIDIN 4(3H) ONE; 2 CYCLOPENTYLTHIO 6 [1 (2,6 DIFLUOROPHENYL)PROPYL] 3,4 DIHYDROPYRIMIDIN 4(3H) ONE; ANTIVIRUS AGENT; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; COMPUTER AIDED DESIGN; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; DRUG DESIGN; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PYRIMIDINES; PYRIMIDINONES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035797356     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010853h     Document Type: Article

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