Mitochondrial thymidine kinase inhibitors

Current Topics in Medicinal Chemistry

Volumn 5, Issue 13, 2005, Pages 1205-1219

  Pérez Pérez, María Jesús ^a   Hernández, Ana Isabel ^a   Priego, Eva María ^a   Rodríguez Barrios, Fátima ^b   Gago, Federico ^b   Camarasa, María José ^a   Balzarini, Jan ^c  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Acyclic nucleoside analogues; Anticancer drugs; Antiviral drugs; Mitochondrial toxicity; Nucleoside metabolism; Thymidine kinase; TK 2

Indexed keywords

1 [4 (TRIPHENYLMETHOXY) 2 BUTENYL]THYMINE; 2' DEOXYNUCLEOSIDE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; ACETANILIDE; ACYCLIC NUCLEOSIDE; ADENOSINE TRIPHOSPHATE; AMIDE; ANTIVIRUS AGENT; CYTOSINE; FIALURIDINE; FURAN DERIVATIVE; GANCICLOVIR; GLUTAMINE; MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; NUCLEOSIDE DERIVATIVE; NUCLEOSIDE TRIPHOSPHATE; PYRIMIDINE NUCLEOSIDE DERIVATIVE; RIBONUCLEOSIDE DERIVATIVE; SORIVUDINE; THYMIDINE KINASE; THYMIDINE KINASE 1; THYMIDINE KINASE 2; THYMIDINE KINASE INHIBITOR; THYMINE DERIVATIVE; TRITYL DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URACIL DERIVATIVE; XANTHENE DERIVATIVE; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; DRUG MECHANISM; DRUG STRUCTURE; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE MUTATION; HERPES SIMPLEX VIRUS 1; HUMAN; IC 50; MITOCHONDRIAL TOXICITY; NONHUMAN; PROTEIN FAMILY; SKELETAL MUSCLE; VIRUS INFECTION;

ANIMALS; DIDEOXYNUCLEOSIDES; DNA, MITOCHONDRIAL; ENZYME INHIBITORS; HUMANS; MITOCHONDRIA; NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE KINASE;

EID: 29444440414     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802605774463097     Document Type: Article

References (52)

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