Cytosolic and mitochondrial deoxyribonucleotidases: Activity with substrate analogs, inhibitors and implications for therapy

Biochemical Pharmacology

Volumn 66, Issue 3, 2003, Pages 471-479

  Mazzon, Cristina ^a   Rampazzo, Chiara ^a   Scaini, Maria Chiara ^a   Gallinaro, Lisa ^a   Karlsson, Anna ^b   Meier, Chris ^c   Balzarini, Jan ^d   Reichard, Peter ^a   Bianchi, Vera ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF HAMBURG   (Germany)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

5 Nucleotidases; Enzyme inhibitors; Mitochondrial toxicity; Nucleoside analogs; Prodrug activation; Resistance

Indexed keywords

1 (2 DEOXY 3,5 O PHOSPHONOMETHYLENE BETA DEXTRO THREO PENTOFURANOSYL)THYMIDINE; 1 (2 PHOSPHONOMETHOXYCYCLOPENTYL)URACIL; 1 (2 PHOSPHONOMETHOXYETHYL) 5 BROMOCYTOSINE; 1 (2 PHOSPHONOMETHOXYETHYL) 5 NITROURACIL; 1 [2' DEOXY 3',5' O (1 PHOSPHONO)BENZYLIDENE BETA DEXTRO THREO PENTOFURANOSYL]THYMINE; 2 (2 PHOSPHONOMETHOXYETHYL) 5 NITROCYTOSINE; 2',3' O (1 PHOSPHONO)BENZYLIDENECYTIDINE; 2',3' O (1 PHOSPHONO)BENZYLIDENETHYMIDINE; 2',3' O (1 PHOSPHONO)BENZYLIDENEURIDINE; 2',3' O (1 PHOSPHONO)ETHYLIDENECYTIDINE; 2',3' O (1 PHOSPHONO)ETHYLIDENETHYMIDINE; 2',3' O (1 PHOSPHONO)ETHYLIDENEURIDINE; 2',3' O PHOSPHONOMETHYLENECYTIDINE; 2',3' O PHOSPHONOMETHYLENETHYMIDINE; 2',3' O PHOSPHONOMETHYLENEURIDINE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; 5' NUCLEOTIDASE; 9 (2 PHOSPHONOMETHOXYETHYL)XANTHINE; 9 BETA DEXTRO ARABINOSYLGUANOSINE; CLADRIBINE; CYTOSINE DERIVATIVE; CYTOSOLIC 5' (3') DEOXYRIBONUCLEOTIDASE; MITOCHONDRIAL 5' (3') DEOXYRIBONUCLEOTIDASE; NUCLEOSIDE DERIVATIVE; NUCLEOTIDASE; PHOSPHATE; PURINE DERIVATIVE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URACIL DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CYTOSOL; DEPHOSPHORYLATION; DRUG ACTIVITY; DRUG MECHANISM; INHIBITION KINETICS; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

EID: 0043198520     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00290-9     Document Type: Article

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