Expression of human mitochondrial thymidine kinase in escherichia coli: Correlation between the enzymatic activity of pyrimidine nucleoside analogues and their inhibitory effect on bacterial growth

Biochemical Pharmacology

Volumn 59, Issue 12, 2000, Pages 1583-1588

  Wang, Jianghai ^a   Su, Changmian ^a   Neuhard, Jan ^b   Eriksson, Staffan ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Drug development; E. coli engineering; Growth inhibition; Phosphorylation; Pyrimidine nucleoside analogues; TK2

Indexed keywords

2' DEOXY 2,2' DIFLUOROCYTIDINE; CLEVUDINE; CYTARABINE; FIALURIDINE; FLOXURIDINE; FLUCYTOSINE DEOXYRIBOSIDE; LAMIVUDINE; PYRIMIDINE NUCLEOSIDE; STAVUDINE; THYMIDINE KINASE; THYMINE ARABINOSIDE; UNCLASSIFIED DRUG; URACIL ARABINOSIDE; ZIDOVUDINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; ENZYME ACTIVITY; ESCHERICHIA COLI; IN VITRO STUDY; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CELL DIVISION; CLONING, MOLECULAR; DEOXYCYTIDINE KINASE; ESCHERICHIA COLI; HUMANS; MITOCHONDRIA; PHOSPHORYLATION; PYRIMIDINE NUCLEOSIDES; RECOMBINANT PROTEINS; THYMIDINE KINASE;

EID: 0034015889     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00285-9     Document Type: Article

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