Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 6963-6968

  Wang, Liya ^a   Saada, Ann ^b   Eriksson, Staffan ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b SHAARE ZEDEK MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOSYNTHESIS; DNA; ENZYMES; MUTAGENESIS; POLYPEPTIDES;

MITOCHONDRIA;

BIOCHEMISTRY;

AMINO ACID; ASPARAGINE; COMPLEMENTARY DNA; DEOXYCYTIDINE; HISTIDINE; ISOLEUCINE; MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; MUTANT PROTEIN; NUCLEOSIDE DERIVATIVE; PYRIMIDINE DEOXYNUCLEOSIDE SALVAGE ENZYME; RECOMBINANT ENZYME; SIGNAL PEPTIDE; THYMIDINE; THYMIDINE KINASE; THYMIDINE KINASE 2; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBUNIT; GENE IDENTIFICATION; GENE MUTATION; GENE STRUCTURE; HUMAN; MITOCHONDRIAL DNA DEPLETION SYNDROME; MITOCHONDRIAL MYOPATHY; MOLECULAR CLONING; MOLECULAR INTERACTION; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; POINT MUTATION; PRECURSOR; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; WILD TYPE; BINDING COMPETITION; BIOLOGICAL MODEL; CHEMISTRY; GEL CHROMATOGRAPHY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS;

GENETTA;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ASPARAGINE; BINDING, COMPETITIVE; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; DNA, MITOCHONDRIAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HISTIDINE; HUMANS; ISOLEUCINE; KINETICS; MITOCHONDRIAL MYOPATHIES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; POINT MUTATION; SEQUENCE HOMOLOGY, AMINO ACID; THYMIDINE KINASE;

EID: 0037470065     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206143200     Document Type: Article

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