Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase

Journal of Medicinal Chemistry

Volumn 45, Issue 19, 2002, Pages 4254-4263

  Hernández, Ana Isabel ^a   Balzarini, Jan ^b   Karlsson, Anna ^c   Camarasa, María José ^a   Pérez Pérez, María Jesús ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; 5' O TRITYLTHYMIDINE; ACYCLIC NUCLEOSIDE; BUTANOL; GUANINE; PYRIMIDINE; THYMIDINE KINASE INHIBITOR; THYMINE; THYMINE DERIVATIVE; TRITYL DERIVATIVE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; MITOCHONDRION; OSTEOSARCOMA CELL; REACTION ANALYSIS;

CATALYSIS; ENZYME INHIBITORS; HERPESVIRUS 1, HUMAN; HUMANS; MITOCHONDRIA; NUCLEOSIDES; PHOSPHORYLATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

EID: 0037068452     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011128+     Document Type: Article

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