Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase

Molecular Pharmacology

Volumn 63, Issue 2, 2003, Pages 263-270

  Balzarini, Jan ^a   Hernández, Ana Isabel ^b   Roche, Philippe ^c   Esnouf, Robert ^c   Karlsson, Anna ^d   Camarasa, Maria José ^b   Pérez Pérez, Maria Jesus ^b  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 TRIPHENYLMETHOXY 2 BUTENYL)THYMIDINE; 2' DEOXYNUCLEOSIDE KINASE; 5 (2 BROMOVINYL) 1 (4 TRIPHENYLMETHOXY 2 BUTENYL)URACIL; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; DEOXYURIDINE DERIVATIVE; KIN 12; KIN 52; NUCLEOSIDE; THYMIDINE KINASE; THYMIDINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; COMPETITIVE INHIBITION; COMPUTER MODEL; DNA SEQUENCE; DROSOPHILA MELANOGASTER; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; ENZYME PURIFICATION; HERPES SIMPLEX VIRUS 1; MITOCHONDRION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING, COMPETITIVE; DROSOPHILA MELANOGASTER; ENZYME INHIBITORS; KINETICS; MITOCHONDRIA; MULTIENZYME COMPLEXES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SIMPLEXVIRUS; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE KINASE; URACIL;

EID: 0037310138     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.2.263     Document Type: Article

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