2′-O-acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase

Biochemical Pharmacology

Volumn 61, Issue 6, 2001, Pages 727-732

  Balzarinia, Jan ^a   Degrève, Bart ^a   Zhu, Chaoyong ^b   Durini, Elisa ^c   Porcu, Luca ^c   De Clercq, Erik ^a   Karlsson, Anna ^b   Manfredini, Stefano ^c  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b Huddinge University   (Sweden)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

Anticancer; Antivirals; AraT; BVaraU; Mitochondria; Thymidine kinase 2

Indexed keywords

1BETA DEXTRO ARABINOFURANOSYLTHYMINE; 5 (2 BROMOVINYL) 1 BETA DEXTRO ARABINOFURANOSYLURACIL; ADENOSINE TRIPHOSPHATE; ARABINOSYL NUCLEOSIDE DERIVATIVE; FUNCTIONAL GROUP; MITOCHONDRIAL ENZYME; NUCLEOSIDE DERIVATIVE; PHOSPHATE; THYMIDINE; THYMIDINE KINASE; THYMIDINE KINASE INHIBITOR; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG; VIRUS ENZYME; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; ARA-T; ARABINONUCLEOSIDE; DRUG DERIVATIVE; PHOSPHORUS; SORIVUDINE; THYMINE ARABINOSIDE; TRITIUM; URACIL ARABINOSIDE;

ARTICLE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HERPES SIMPLEX VIRUS 1; PHOSPHATE TRANSPORT; PHOSPHORYLATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VARICELLA ZOSTER VIRUS; BINDING COMPETITION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; KINETICS; METABOLISM; MITOCHONDRION;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; ARABINOFURANOSYLURACIL; ARABINONUCLEOSIDES; BINDING, COMPETITIVE; HUMANS; KINETICS; MITOCHONDRIA; PHOSPHORUS RADIOISOTOPES; PHOSPHORYLATION; THYMIDINE; THYMIDINE KINASE; TRITIUM;

EID: 0035866551     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00529-9     Document Type: Article

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