Quantum chemical modeling of the GTP hydrolysis by the RAS-GAP protein complex

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1700, Issue 1, 2004, Pages 125-136

  Topol, Igor A ^a   Cachau, Raul E ^a   Nemukhin, Alexander V ^b   Grigorenko, Bella L ^b   Burt, Stanley K ^a  

^a SAIC FREDERICK INC   (United States)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Active site mutation; Enzyme mechanism; GTP hydrolysis; Hybrid QM MM method; RAS GAP complex

Indexed keywords

GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAS PROTEIN; WATER;

AB INITIO CALCULATION; ARTICLE; ATOM; CATALYSIS; CATALYST; CHEMICAL BOND; HYBRID; HYDROLYSIS; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; PRIORITY JOURNAL; QUANTUM CHEMISTRY; THEORY;

CRYSTALLOGRAPHY, X-RAY; GUANOSINE TRIPHOSPHATE; HYDROLYSIS; MACROMOLECULAR SUBSTANCES; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; RAS GTPASE-ACTIVATING PROTEINS;

EID: 2942699985     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2004.04.007     Document Type: Article

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