Why Does the Ras Switch "Break" by Oncogenic Mutations?

Proteins: Structure, Function and Genetics

Volumn 55, Issue 1, 2004, Pages 1-10

  Shurki, Avital ^a   Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Allostery; Catalysis; G proteins; Gln 61 oncogenic mutation; RasGAP; Signal transduction

Indexed keywords

GLUTAMINE; GUANOSINE TRIPHOSPHATASE; RAS PROTEIN;

ALLOSTERISM; ARTICLE; CATALYSIS; COMPLEX FORMATION; COMPUTER SIMULATION; ELECTRICITY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE MUTATION; GENE SWITCHING; MOLECULAR STABILITY; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STEREOCHEMISTRY;

ALLOSTERIC SITE; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; GENES, RAS; GLUTAMINE; MODELS, MOLECULAR; MUTATION; ONCOGENE PROTEIN P21(RAS); PROTEIN CONFORMATION; RAS GTPASE-ACTIVATING PROTEINS;

EID: 1442324695     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.20004     Document Type: Article

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