The arginine finger of RasGap helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 11, 2001, Pages 6033-6038

  Resat, Haluk ^a   Straatsma, T P ^a   Dixon, David A ^a   Miller, John H ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMMONIA; ARGININE; CARBONYL DERIVATIVE; GAMMA PHOSPHATE; GLUTAMINE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; OXYGEN; PHOSPHATE; PROTEIN P120; RAS PROTEIN; UNCLASSIFIED DRUG; WATER;

ARTICLE; CARCINOGENESIS; CATALYSIS; CELL DIFFERENTIATION; CELL MEMBRANE; CELL PROLIFERATION; CRYSTAL STRUCTURE; GENE MUTATION; HYDROLYSIS; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY;

ARGININE; BINDING SITES; CLUSTER ANALYSIS; GLUTAMINE; GUANOSINE TRIPHOSPHATE; HYDROLYSIS; P120 GTPASE ACTIVATING PROTEIN; PROTO-ONCOGENE PROTEINS P21(RAS); WATER;

EID: 0035933139     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.091506998     Document Type: Article

References (38)

1. Bourne, H. R., Sanders, D. A. & McCormick, F. (1990) Nature (London) 348, 125-132.
2. Bourne, H. R., Sanders, D. A. & McCormick, F. (1991) Nature (London) 349, 117-127.
3. Lowy, D. R. & Willumsen, B. M. (1993) Annu. Rev. Biochem. 62, 851-891.
4. Wiesmuller, L. & Wittinghofer, A. (1994) Cell. Signalling 6, 247-267.
5. Hilgenfeld, R. (1995) Nat. Struct. Biol. 2, 3-6.
6. Maegley, K. A., Admiraal, S. J. & Herschlag, D. (1996) Proc. Natl. Acad. Sci. USA 93, 8160-8166.
7. Kjeldgaard, M., Nyborg, J. & Clark, B. C. (1996) FASEB J. 10, 1347-1368.
8. Trahey, M., Wong, G., Halenbeck, R., Rubinfeld, B., Martin, G. A., Ladner, M., Long, C. M., Crosier, W. J., Watt, K., Koths, K. & McCormick, F. (1988) Science 242, 1697-1700.
9. Gibbs, J. B., Schaber, M. D., Alllard, W. J., Sigal, I. S. & Scolnick, E. M. (1988) Proc. Natl. Acad. Sci. USA 85, 5026-5030.
10. Bollag, G. & McCormick, F. (1991) Nature (London) 351, 576-579.
11. Gideon, P., John, J., Frech, M., Lautwein, A., Clark, R., Scheffler, J. E. & Wittinghofer, A. (1992) Mol. Cell. Biol. 12, 2050-2056.
12. Eccleston, J. F., Moore, K. J. M., Morgan, L., Skinner, R. H. & Lowe, P. N. (1993) J. Biol. Chem. 268, 27012-27019.
13. Barbacid, M. (1987) Annu. Rev. Biochem. 56, 779-827.
14. Bos, J. (1989) Cancer Res. 49, 4682-4689.
15. Chung, H.-H., Benson, D. R. & Schultz, P. G. (1993) Science 259, 806-808.
16. Langen, R., Schweins, T. & Warshel, A. (1992) Biochemistry 31, 8691-8696.
17. Trahey, M. & McCormick, F. (1987) Science 238, 542-545.
18. Schweins, T., Geyer, M., Scheffzek, K., Warshel, A., Kalbitzer, H. R. & Wittinghofer, A. (1995) Nat. Struct. Biol. 2, 36-44.
19. Pai, E. F., Krenkel, U., Petsko, G. A., Goody, R. S., Kabsch, W. & Wittinghofer, A. (1990) EMBO J. 9, 2351-2359.
20. Krenkel, U., Schlichting, I., Scherer, A., Schumann, R., Frech, M., John, J., Kabsch, W., Pai, E. F. & Wittinghofer, A. (1990) Cell 62, 539-548.
21. Prive, G. G., Milburn, M. V., Tong, L., DeVos, A. M., Yamaizumi, Z., Nishimura, S. & Kim, S.-H. (1992) Proc. Natl. Acad. Sci. USA 89, 3649-3653.
22. Schweins, T., Langen, R. & Warshel, A. (1994) Nat. Struct. Biol. 1, 476-484.
23. Sondek, J., Lambright, D. G., Noel, J. P., Hamm, H. E. & Sigler, P. B. (1994) Nature (London) 372, 276-279.
24. Ahmadian, M. R., Stege, P., Scheffzek, K. & Wittinghofer, A. (1997) Nat. Struct. Biol. 4, 686-689.
25. Glennon, T. M., Villa, J. & Warshel, A. (2000) Biochemistry 39, 9641-9651.
26. Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmuller, L., Lautwein, A., Schmitz, F. & Wittinghufer, A. (1997) Science 277, 333-338.
27. Brooks, B. R., Bruccoleri, R. E., Olafson, B. D., States, D. J., Swaminathan, S. & Karplus, M. (1983) Comp. Chem. 4, 187-217.
28. Antosiewitz, J., McCammon, J. A. & Gilson, M. (1994) J. Mol. Biol. 238, 415-436.
29. Madura, J. D., Briggs, J. M., Wade, R. C., Davis, M. E., Luty, B. A., Ilin, A., Antosiewicz, J., Gilson, M. K., Bagheri, B., Scott, L. R. & McCammon, J. A. (1995) Comput. Phys. Commun. 91, 57-95.
30. Harrison, R. J., Nichols, J. A., Straatsma, T. P., Dupuis, M., Bylaska, E. J., Fann, G. I., Windus, T. L., Apra, E., Anchell, J., Bernholdt, D., et al. (2000) NWCHEM, A Computational Chemistry Package for Parallel Computers (Pacific Northwest National Laboratory, Richland, WA), Version 4.0.
31. Cornell, W. D., Cieplak, P., Bayly, C. I., Could, I. R., Merz, K. M., Ferguson, D. M., Spellmeyer, D. C., Fox, T., Caldwell, J. W. & Kollman, P. A. (1995) J. Am. Chem. Soc. 117, 5179-5197.
32. Foley, C. K., Pedersen, L. G., Charifson, P. S., Darden, T. A., Wittinghofer, A., Pai, E. F. & Anderson, M. W. (1992) Biochemistry 31, 4951-4959.
33. Frech, M., Darden, T. A., Pedersen, L. G., Foley, C. K., Charifson, P. S., Anderson, M. W. & Wittinghofer, A. (1994) Biochemistry 33, 3237-3244.
34. Diaz, J. F., Wroblowski, B. & Engelborghs, Y. (1995) Biochemistry 34, 12038-12047.
35. Ma, J. & Karplus, M. (1997) Proc. Natl. Acad. Sci. USA 94, 11905-11910.
36. Coleman, D. E., Berghuis, A. M., Lee, E., Linder, M. E., Gilman, A. G. & Sprang, S. R. (1994) Science 265, 1405-1412.
37. Mittal, R., Ahmadian, M. R., Goody, R. S. & Wittinghofer, A. (1996) Science 273, 115-117.
38. Farrar, C. T., Ma, J., Singel, D. J. & Halkides, C. J. (2000) Structure (London) 8, 1279-1287.