Mechanistic analysis of the observed linear free energy relationships in p21(ras) and related systems

Biochemistry

Volumn 35, Issue 45, 1996, Pages 14232-14243

  Schweins, T ^a,b   Warshel, A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN P21;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; HYDROLYSIS; LINEAR ENERGY TRANSFER; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; PROTON TRANSPORT;

CATALYSIS; DEUTERIUM; GLUTAMINE; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; GUANOSINE TRIPHOSPHATE; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROTEINS; PROTO-ONCOGENE PROTEINS P21(RAS); PROTONS; RAS GTPASE-ACTIVATING PROTEINS; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

FELIS CATUS;

EID: 0029843561     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi961119g     Document Type: Article

References (52)

1. Adamo, C., & Lelj, F. (1995) Int. J. Quantum Chem. 56, 645-653.
2. Admiraal, S. J., & Herschlag, D. (1995) Chem. Biol. 2, 729-739.
3. Albery, W. J. (1980) Annu. Rev. Phys. Chem. 31, 227.
4. Åqvist, J., & Warshel, A. (1993) Chem. Rev. 93, 2523-2544.
5. Åqvist, J., & Hansson, T. (1996) J. Phys. Chem. 100 (in press).
6. Åqvist, J., Medina, C., & Samuelson, J.-E. (1994) Protein Eng. 7, 385-391.
7. Brownbridge, G. G., Lowe, P. N., Moore, K. J., Skinner, R. H., & Webb, M. (1993) J. Biol. Chem. 268, 10914-10919.
8. Cleland, W. (1990) Enzymes 19, 99-158.
9. Davis, A. M., Hall, A. D., & Williams, A. (1988) J. Am. Chem. Soc. 110, 5105-5108.
10. Eccleston, J. F., & Webb, M. R. (1982) J. Biol. Chem. 257, 5046-5049.
11. Fersht, A. R. (1984) Enzyme. Structure and Mechanism, 2nd ed., Freeman, New York.
12. Fersht, A. R., Leatherbarrow, R. J., & Wells, T. N. C. (1986) Nature 322, 284-286.
13. Feuerstein, J., Goody, R. S., & Webb, M. R. (1989) J. Biol. Chem. 264, 6188-6190.
14. Fisher, A. J., et al. (1995) Biochemistry 34, 8960.
15. Fothergill, M., Goodmann, M. F., Petruska, J., & Warshel, A. (1995) J. Am. Chem. Soc. 117, 11619-11627.
16. Gerlt, J. A., & Gassman, P. G. (1993) J. Am. Chem. Soc. 115, 11552-11568.
17. Goody, R. S. (1994) Nature 372, 220.
18. Guthrie, J. P. (1977) J. Am. Chem. Soc. 99, 3991-4001
19. Guthrie, J. P. & Kluger, R. (1993) J. Am. Chem. Soc. 115, 11569-11572.
20. Hammett, L. P. (1937) J. Am. Chem. Soc. 59, 96.
21. Hammond, G. S. (1955) J. Am. Chem. Soc. 77, 334.
22. Hollfelder F., & Herschlag, D. (1995) Biochemistry 34, 12255-12264.
23. Hrouda, V., Florián, J., Polásek, M., & Hobza, P. (1994) J. Phys. Chem. 98, 4742-4747.
24. Hwang, J. K., & Warshel, A. (1987) J. Am. Chem. Soc. 109, 715.
25. Hwang, J. K., King, G., Creighton, S., & Warshel, A. (1988) J. Am. Chem. Soc: 110, 5297.
26. Jencks, W. P. (1987) Catalysis in Chemistry and Enzymology, Dover Public, New York.
27. Jencks, W. P., & Salvesen, K. (1971) J. Am. Chem. Soc: 93, 4433.
28. King, G., & Warshel, A. (1989) J. Chem. Phys. 91, 3647-3661.
29. Kong, Y. S., & Warshel, A. (1995) J. Am. Chem. Soc. 117, 6234-6242.
30. Kreevoy, M. M., & Kotchevar, A. T. (1990) J. Am. Chem. Soc. 112, 3519.
31. Kuharski, R. A., Bader, J. S., Chandler, D., Sprik, M., Klein, M., & Impey, R. W. (1988) J. Chem. Phys. 89, 9219.
32. Langen, R., Schweins, T., & Warshel, A. (1992) Biochemistry 31, 8691-8696.
33. Leffler, J. E., & Grunwald, E. (1963) Rates and Equilibria of Organic Reactions, Wiley & Sons, New York.
34. Maegley, K. A., Admiral, S. J., & Herschlog, D. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 8160-8166.
35. Marcus, R. A. (1964) Annu. Rev. Phys. Chem. 15, 155.
36. Marcus, R. A. (1968) J. Phys. Chem. 72, 891.
37. Mittal, R., Ahmadian, M. R., Goody, R. S., & Wittinghofer, A. (1996) Science 273, 115.
38. Papazyan, A., & Maroncelli, M. (1991) J. Chem. Phys. 95, 9219.
39. Pross, A., & Shaik, S. S. (1983) Acc. Chem. Res. 16, 363.
40. Ren, X., Tu, C., Laipis, P. J., & Silverman, D. N. (1995) Biochemistry 34, 8492-8498.
41. Schowen, K. B., & Schowen, R. L. (1982) Methods Enzymol. 87, 551.
42. Schweins, T., Langen, R., & Warshel, A. (1994) Nature Struc. Biol. 1, 476-484.
43. Schweins, T., Geyer, M., Scheffzek, K., Warshel, A., Kalbitzer, H. R., & Wittinghofer, A. (1995) Nat. Struct. Biol. 2, 36-44.
44. Schweins, T., Geyer, M., Kalbitzer, H. R., Wittinghofer, A., & Warshel, A. (1996) Biochemistry 35, xxxxx-xxxxx.
45. Sondek, J., Lambright, D. G., Noel, J. P., Hamm, H. E., & Sigler, P. B. (1994) Nature 372, 276-279.
46. Toney, M. D., & Kirsch, J. F. (1989) Science 243, 1485-1488.
47. Warshel, A. (1984) Pontif. Acad. Sci. Script. Varia. 55, 59.
48. Warshel, A. (1991) Computer Modeling of Chemical Reactions in Enzyme and Solutions, Wiley & Sons, New York.
49. Warshel, A., & Weiss, R. M. (1980) J. Am. Chem. Soc. 102, 6218.
50. Warshel, A., Hwang, J. K., & Åqvist, J. (1992) Faraday Discuss. 93, 225-238.
51. Warshel, A., Schweins, T., & Fothergil, M. (1994) J. Am. Chem. Soc. 116, 8437-8442.
52. Yadav, A., Jackson, R., Holbrook, J. J., & Warshel, A. (1991) J. Am. Chem. Soc. 113, 4800-4805.