Relationship between posterior capsule opacification and intraocular lens biocompatibility

Progress in Retinal and Eye Research

Volumn 23, Issue 3, 2004, Pages 283-305

  Saika, Shizuya ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLIC ACID; CYTOKINE; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; METALLOPROTEINASE; POLYMER; SILICONE; SMAD3 PROTEIN; SMAD4 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

AQUEOUS HUMOR; BIOCOMPATIBILITY; CATARACT; CATARACT EXTRACTION; CELL DAMAGE; CELL DIFFERENTIATION; CELL PROLIFERATION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROSIS; FOREIGN BODY; GENE EXPRESSION; HEALING; HISTOPATHOLOGY; HUMAN; HYDROGEL; HYDROPHILICITY; IMMUNOHISTOCHEMISTRY; LENS IMPLANT; MESENCHYME; MODULATION; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; REGENERATION; REVIEW; SIGNAL TRANSDUCTION; TISSUE REPAIR; WOUND HEALING;

ANIMALS; BIOCOMPATIBLE MATERIALS; CATARACT; CELL DIFFERENTIATION; CELL DIVISION; EPITHELIAL CELLS; FOREIGN-BODY REACTION; HUMANS; LENS CAPSULE, CRYSTALLINE; LENS IMPLANTATION, INTRAOCULAR; LENSES, INTRAOCULAR; POSTOPERATIVE COMPLICATIONS;

EID: 2942598299     PISSN: 13509462     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2004.02.004     Document Type: Review

References (206)

1. Adler R., Belecky-Adams T.L. The role of bone morphogenetic proteins in the differentiation of the ventral optic cup. Development. 129:2002;3161-3171
2. Allen J.B., Davidson M.G., Nasisse M.P., Fleisher L.N., McGahan M.C. The lens influences aqueous humor levels of transforming growth factor-beta 2. Graefes Arch. Clin. Exp. Ophthalmol. 236:1998;305-311
3. Apple D.J., Werner L. Complications of cataract and refractive surgery. a clinicopathological documentation Trans. Am. Ophthalmol. Soc. 99:2001;95-107
4. Apple D.J., Werner L., Pandey S.K. Newly recognized complications of posterior chamber intraocular lenses (editorial). Arch. Ophthalmol. 119:2001;581-582
5. Ashcroft G.S., Yang X., Glick A.B., Weinstein M., Letterio J.L., Mizel D.E., Anzano M., Greenwell-Wild T., Wahl S.M., Deng C., Roberts A.B. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat. Cell Biol. 1:1999;260-266
6. Aslam T.M., Dhillon B., Werghi N., Taguri A., Wadood A. Systems of analysis of posterior capsule opacification. Br. J Ophthalmol. 86:2002;1181-1186
7. Auffarth G.U., Golescu A., Becker K.A., Volcker H.E. Quantification of posterior capsule opacification with round and sharp edge intraocular lenses. Ophthalmology. 110:2003;772-780
8. Barbour, W., Saika, S., Miyamoto, T., Ohkawa, K., Utsunomiya, H., Ohnishi, Y., 2004. Expression patterns of integrin α-subunits in murine lens during embryonic development and wound healing. Curr Eye Res. in press.
9. Barman S.A., Hollick E.J., Boyce J.F., Spalton D.J., Uyyanonvara B., Sanguinetti G., Meacock W. Quantification of posterior capsular opacification in digital images after cataract surgery. Invest. Ophthalmol. Vis. Sci. 41:2000;3882-3892
10. Bates R.C., Mercurio A.M. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol. Biol. Cell. 14:2003;1790-1800
11. Belecky-Adams T.L., Adler R., Beebe D.C. Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation. Development. 129:2002;3795-3802
12. Boukamp P., Fusenig N.E. "trans-differentiation" from epidermal to mesenchymal/myogenic phenotype is associated with a drastic change in cell-cell and cell-matrix adhesion molecules. J. Cell Biol. 120:1993;981-993
13. Boyce J.F., Bhermi G.S., Spalton D.J., El-Osta A.R. Mathematical modeling of the forces between an intraocular lens and the capsule. J. Cataract Refract. Surg. 28:2002;1853-1859
14. Chen K.H., Harris D.L., Joyce N.C. Tgf-β2 in aqueous humor suppresses S-phase entry in cultured corneal endothelial cells. Invest. Ophthalmol. Vis. Sci. 40:1999;2513-2519
15. Connor T.B. Jr., Roberts A.B., Sporn M.B., Danielpour D., Dart L.L., Michels R.G., de Bustros S., Enger C., Kato H., Lansing M., et al. Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye. J. Clin. Invest. 83:1989;1661-1666
16. Coombes A., Seward H. Posterior capsular opacification prevention. IOL design and material Br. J. Ophthalmol. 83:1999;640-641
17. Couderc B.C., de Neuville S., Douin-Echinard V., Serres B., Manenti S., Darbon J.M., Malecaze F. Retrovirus-mediated transfer of a suicide gene into lens epithelial cells in vitro and in an experimental model of posterior capsule opacification. Curr. Eye Res. 19:1999;472-482
18. Cunanan C.M., Ghazizadeh M., Buchen S.Y., Knight P.M. Contact angle analysis of intraocular lenses. J. Cataract Refract. Surg. 24:1998;341-351
19. Davidson J.A. Capsule contraction syndrome. J. Cataract Refract. Surg. 19:1993;582-589
20. de Iongh R.U., Gordon-Thomson C., Chamberlain C.G., Hales A.M., McAvoy J.W. TGFβ receptor expression in lens. implications for differentiation and cataractogenesis Exp. Eye Res. 72:2001;649-659
21. de Iongh R.U., Lovicu F.J., Overbeek P.A., Schneider M.D., Joya J., Hardeman E.D., McAvoy J.W. Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation. Development. 128:2001;3995-4010
22. Denton C.P., Zheng B., Evans L.A., Shi-wen X., Ong V.H., Fisher I., Lazaridis K., Abraham D.J., Black C.M., de Crombrugghe B. Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFβ) receptor leads to paradoxical activation of TGFβ signaling pathways with fibrosis in transgenic mice. J. Biol. Chem. 278:2003;25109-25119
23. Dooley S., Hamzavi J., Breitkopf K., Wiercinska E., Said H.M., Lorenzen J., ten Dijke P., Gressner A.M. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology. 125:2003;178-191
24. Duncan G., Wormstone I.M., Liu C.S., Marcantonio J.M., Davies P.D. Thapsigargin-coated intraocular lenses inhibit human lens cell growth. Nat. Med. 3:1997;1026-1028
25. Emery J. Capsular opacification after cataract surgery. Curr. Opin. Ophthalmol. 10:1999;73-80
26. Evans R.A., Tian Y.C., Steadman R., Phillips A.O. TGF-β1-mediated fibroblast-myofibroblast terminal differentiation - the role of Smad proteins. Exp. Cell Res. 282:2003;90-100
27. Faber S.C., Dimanlig P., Makarenkova H.P., Shirke S., Ko K., Lang R.A. FGF receptor signaling plays a role in lens induction. Development. 128:2001;4425-4438
28. Faber S.C., Robinson M.L., Makarenkova H.P., Lang R.A. BMP signaling is required for development of primary lens fiber cells. Development. 129:2002;3727-3737
29. Flanders K.C., Major C.D., Arabshahi A., Aburime E.E., Okada M.H., Fujii M., Blalock T.D., Schultz G.S., Sowers A., Anzano M.A., Mitchell J.B., Russo A., Roberts A.B. Interference with transforming growth factor-β/Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am. J. Pathol. 163:2003;2247-2257
30. Frank S., Madlener M., Werner S. Transforming growth factors β1, β2, and β3 and their receptors are differentially regulated during normal and impaired wound healing. J. Biol. Chem. 271:1996;10188-10193
31. Hales A.M, Schulz M.W., Chamberlain C.G., McAvoy J.W. TGF-β1 induces lens cells to accumulate α-smooth muscle actin, a marker for subcapsular cataracts. Curr. Eye Res. 13:1994;885-890
32. Hak S.C., Seung J.L., Hong B.K. Effect of mitomycin C on posterior capsule opacification in rabbit eyes. J. Cataract Refract Surg. 26:2000;1537-1542
33. Hay E.D. An overview of epithelio-mesenchymal transformation. Acta. Anat. (Basel). 154:1995;8-20
34. Hay E.D., Zuk A. Transformations between epithelium and mesenchyme. normal, pathological, and experimentally induced Am. J. Kidney Dis. 26:1995;678-690
35. Hayashi H., Hayashi K., Nakao F., Hayashi F. Anterior capsule contraction and intraocular lens dislocation in eyes with pseudoexfoliation syndrome. Br. J. Ophthalmol. 82:1998;1429-1432
36. Hayashi H., Hayashi K., Nakao F., Hayashi F. Quantitative comparison of posterior capsule opacification after polymethylmethacrylate, silicone, and soft acrylic intraocular lens implantation. Arch. Ophthalmol. 116:1998;1579-1582
37. Hayashi K., Hayashi H., Nakao F., Hayashi F. Reduction in the area of the anterior capsule opening after polymethylmethacrylate, silicone, and soft acrylic intraocular lens implantation. Am. J. Ophthalmol. 123:1997;441-447
38. Hayashi K., Hayashi H., Nakao F., Hayahsi F. In vivo quantitative masurement of posterior capsule opacification after extracapsular cataract surgery. Am. J. Ophthalmol. 125:1998;837-843
39. Hayashi K., Hayashi H., Nakao F., Hayashi F. Anterior capsule contraction and intraocular lens decentration and tilt after hydrogel lens implantation. Br. J. Ophthalmol. 85:2001;1294-1297
40. Hayashi K., Hayashi H., Nakao F., Hayashi F. Posterior capsule opacification after cataract surgery in patients with diabetes mellitus. Am. J. Ophthalmol. 134:2002;10-16
41. Hollick E.J., Spalton D.J., Ursell P.G. Surface cytologic features on intraocular lenses. can increased biocompatibility have disadvantages? Arch. Ophthalmol. 117:1999;872-878
42. Hollick E.J., Spalton D.J., Ursell P.G., Meacock W.R., Barman S.A., Boyce J.F. Posterior capsular opacification with hydrogel, polymethylmethacrylate, and silicone intraocular lenses. two-year results of a randomized prospective trial Am. J. Ophthalmol. 129:2000;577-584
43. Holmes A., Abraham D.J., Sa S., Shiwen X., Black C.M., Leask A. CTGF and SMADs, maintenance of Scleroderma phenotype is independent of SMAD signaling. J. Biol. Chem. 276:2001;10594-10601
44. Hu D.N., McCormick S.A., Lin A.Y., Lin J.Y. Tgf-β2 inhibits growth of uveal melanocytes at physiological concentrations. Exp. Eye Res. 67:1998;143-150
45. Huang J.X., Feldmeier M., Shui Y.B., Beebe D.C. Evaluation of fibroblast growth factor signaling during lens fiber cell differentiation. Invest. Ophthalmol. Vis. Sci. 44:2003;680-690
46. Hung F.C., Zhao S., Chen Q., Overbeek P.A. Retinal ablation and altered lens differentiation induced by ocular overexpression of BMP7. Vision Res. 42:2002;427-438
47. Ionides A., Dowler J.G., Hykin P.G., Rosen P.H., Hamilton A.M. Posterior capsule opacification following diabetic extracapsular cataract extraction. Eye. 8:1994;535-537
48. Iozzo R.V. Matrix proteoglycans. from molecular design to cellular function Annu. Rev. Biochem. 67:1998;609-652
49. Ishibashi T., Araki H., Sugai S., Tawara A., Ohnishi Y., Inomata H. Anterior capsule opacification in monkey eyes with posterior chamber intraocular lenses. Arch. Ophthalmol. 111:1993;1685-1690
50. Ishibashi T., Sugai S., Kubota T., Ohnishi Y., Inomata H. Cytopathology of early cellular reaction on implant lenses in monkeys. A transmission electron microscopic study. Graefes Arch. Clin. Exp. Ophthalmol. 227:1989;470-475
51. Ishida I., Saika S., Ohnishi Y. Effect of minoxidil on rabbit lens epithelial cell behavior in vitro and in situ. Graefes Arch. Clin. Exp. Ophthalmol. 239:2001;770-777
52. Ishida I., Saika S., Miyamoto T., Ohnishi Y. Expression pattern of osteonectin/SPARK in human anterior subcapsular cataract. Capsular opacification, and healing, injured, mouse lens. Invest. Ophthalmol. Vis. Sci. (Suppl) ARVO abstract. #3503:2003;145
53. Itoh S., Thorikay M., Kowanetz M., Moustakas A., Itoh F., Heldin C.H., ten Dijke P. Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses. J. Biol. Chem. 278:2003;3751-3761
54. Izak A.M., Werner L., Pandey S.K., Apple D.J. Calcification of modern foldable hydrogel intraocular lens designs. Eye. 17:2003;393-406
55. Jampel H.D., Roche N., Stark W.J., Roberts A.B. Transforming growth factor-β in human aqueous humor. Curr. Eye Res. 9:1990;963-969
56. Kaartinen V., Voncken J.W., Shuler C., Warburton D., Bu D., Heisterkamp N., Groffen J. Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction. Nat. Genet. 11:1995;415-421
57. Kalluri R., Neilson E.G. Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 112:2003;1776-1784
58. Kampmeier J., Behrens A., Wang Y., Yee A., Anderson W.F., Hall F.L., Gordon E.M., McDonnell P.J. Inhibition of rabbit keratocyte and human fetal lens epithelial cell proliferation by retrovirus-mediated transfer of antisense cyclin G1 and antisense MAT1 constructs. Hum. Gene Ther. 11:2000;1-18
59. Kanagawa R., Saika S., Ohmi S., Tamura M., Nakao T. Presence and distribution of fibronectin on the surface of implanted intraocular lenses in rabbits. Graefes Arch. Clin. Exp. Ophthalmol. 228:1990;398-400
60. Kao W.W., Liu C.Y. Roles of lumican and keratocan on corneal transparency. Glycoconj. J. 19:2002;275-285
61. Kappelhof J.P., Pameyer J.H., De Jong P.T.V.M., Jongkind J.F., Vrensen G.F.J.M. The proteinaceous coating and cytrology of implanted lenses in rabbits. Am. J. Ophthalmol. 102:1986;750-758
62. Karin M., Liu Z., Zandi E. AP-1 function and regulation. Curr. Opin. Cell Biol. 9:1997;240-246
63. Kato K., Kurosaka D., Nagamoto T. Apoptotic cell death in rabbit lens after lens extraction. Invest. Ophthalmol. Vis. Sci. 38:1997;2322-2330
64. Kawashima Y., Saika S., Miyamoto T., Yamanaka O., Okada Y., Tanaka S., Ohnishi Y. Matrix metalloproteinases and tissue inhibitors of metalloproteinases of fibrous humans lens capsules with intraocular lenses. Curr. Eye Res. 21:2000;962-967
65. Kelley T.J., Elmer H.L., Corey D.A. Reduced Smad3 protein expression and altered transforming growth factor-beta1-mediated signaling in cystic fibrosis epithelial cells. Am. J. Respir. Cell Mol. Biol. 25:2001;732-738
66. Khawly J.A., Lambert R.J., Jaffe G.J. Intraocular lens changes after short- and long-term exposure to intraocular silicone oil. An in vivo study. Ophthalmology. 105:1998;1227-1233
67. Koch M.U., Kalicharan D., van der Want J.J. Lens epithelial cell layer formation related to hydrogel foldable intraocular lenses. J. Cataract Refract. Surg. 25:1999;1637-1640
68. Kokawa N., Sotozono C., Nishida K., Kinoshita S. High total TGF-β2 levels in normal human tears. Curr. Eye Res. 15:1996;341-343
69. Kruger A.J., Schauersberger J., Abela C., Schild G., Amon M. Two year results. sharp versus rounded optic edges on silicone lenses J. Cataract Refract. Surg. 26:2000;566-570
70. Kurosaka D., Nagamoto T. Inhibitory effect of TGF-β2 in human aqueous humor on bovine lens epithelial cells proliferation. Invest. Ophthalmol. Vis. Sci. 35:1994;3408-3412
71. Kurosaka D., Obasawa M., Kurosaka H., Nakamura K. Inhibition of lens epithelial cell migration by an acrylic intraocular lens in vitro. Ophthalmic Res. 34:2002;29-37
72. Lan H.Y., Mu W., Tomita N., Huang X.R., Li J.H., Zhu H.J, Morishita R., Johnson R.J. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J. Am. Soc. Nephrol. 14:2003;1535-1548
73. Lee E.H., Joo C.K. Role of transforming growth factor-β in transdifferentiation and fibrosis of lens epithelial cells. Invest. Ophthalmol. Vis. Sci. 40:1999;2025-2032
74. Lee J.H., Wan X.H., Song J., Kang J.J., Chung W.S., Lee E.H., Kim E.K. TGF-β-induced apoptosis and reduction of Bcl-2 in human lens epithelial cells in vitro. Curr. Eye Res. 25:2002;147-1453
75. Liberati N.T., Datto M.B., Frederick J.P., Shen X., Wong C., Rougier-Chapman E.M., Wang X.F. Smads bind directly to the Jun family of AP-1 transcription factors. Proc. Natl. Acad. Sci. USA. 96:1999;4844-4849
76. Linnola R.J., Werner L., Pandey S.K., Escobar-Gomez M., Znoiko S.L., Apple D.J. Adhesion of fibronectin, vitronectin, laminin, and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes. Parts 1 and 2. J. Cataract Refract. Surg. 26:2000;1792-1818
77. Lovicu F.J, McAvoy J.W. FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling. Development. 128:2001;5075-5084
78. Lovicu F.J., Schulz M.W., Hales A.M., Vincent L.N., Overbeek P.A., Chamberlain C.G., McAvoy J.W. TGFβ induces morphological and molecular changes similar to human anterior subcapsular cataract. Br. J. Ophthalmol. 86:2002;220-226
79. Malecaze F., Couderc B., de Neuville S., Serres B., Mallet J., Douin-Echinard V., Manenti S., Revah F., Darbon J.M. Adenovirus-mediated suicide gene transduction. feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits Hum. Gene Ther. 10:1999;2365-2372
80. Maloof A., Neilson G., Milverton E.J., Pandey S. Selective and specific targeting of lens epithelial cells during cataract surgery using sealed-capsule irrigation. J. Cataract Refract. Surg. 29:2003;1566-1568
81. Mamalis N. Intraocular lens biocompatibility. J. Cataract Refract. Surg. 28:2002;1-2
82. Martin P. Wound healing-aiming for perfect skin regeneration. Science. 276:1997;75-80
83. Massague J., Wotton D. Transcriptional control by the TGF-β/Smad signaling system. EMBO J. 19:2000;1745-1754
84. Massague J., Chen Y-G. Controlling TGF-β signaling. Genes Dev. 14:2000;644-672
85. Masszi A., Di Ciano C., Sirokmany G., Arthur W.T., Rotstein O.D., Wang J., McCulloch C.A., Rosivall L., Mucsi I., Kapus A. Central role for Rho in TGF-β1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am. J. Physiol. Renal Physiol. 284:2003;F911-924
86. McAvoy J.W., Chamberlain C.G. Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration. Development. 107:1989;221-228
87. McAvoy J.W., Chamberlain C.G., de Iongh R.U., Hales A.M., Lovicu F.J. Lens development. Eye. 13(Part 3b):1999;425-437
88. McCulley J.P. Biocompatibility of intraocular lenses. Eye Contact Lens. 29:2003;155-163
89. McDonnell P.J., Green W.R., Maumeneee A.E., Iliff W.J. Pathology of intraocular lenses in 33 eyes examined postmortem. Ophthalmology. 90:1983;386-403
90. Meacock W.R., Spalton D.J., Boyce J.F., Jose R.M. Effect of optic size on posterior capsule opacification. 5.5 mm versus 6.0 mm AcrySof intraocular lenses J. Cataract Refract. Surg. 27:2001;1194-1198
91. Meacock W.R., Spalton D.J., Khan S. The effect of texturing the intraocular lens edge on postoperative glare symptoms. a randomized, prospective, double-masked study Arch. Ophthalmol. 120:2002;1294-1298
92. Mishima H., Hibino T., Hara H., Murakami J., Otori T. SPARC from corneal epithelial cells modulates collagen contraction by keratocytes. Invest. Ophthalmol. Vis. Sci. 39:1998;2547-2553
93. Mori Y., Chen S.J., Varga J. Modulation of endogenous Smad expression in normal skin fibroblasts by transforming growth factor-beta. Exp. Cell Res. 258:2000;374-383
94. Moustakas A., Pardali K., Gaal A., Heldin C.H. Mechanisms of TGF-β signaling in regulation of cell growth and differentiation. Immunol. Lett. 82:2002;85-91
95. Mulhall K.J., Curtin W.A., Given H.F. Comparison of different anti-inflammatory agents in suppressing the monocyte response to orthopedic particles. Orthopedics. 26:2003;1219-1223
96. Nagata T., Minakata A., Watanabe I. Adhesiveness of AcrySof to a collagen film. J. Cataract Refract. Surg. 24:1998;367-370
97. Nakao A., Fujii M., Matsumura R., Kumano K., Saito Y., Miyazono K., Iwamoto I. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J. Clin. Invest. 104:1999;5-11
98. Nieto M.A. The snail superfamily of zinc-finger transcription factors. Nature reviews (Mol. Cell Biol.). 3:2000;155-166
99. Nishi O., Nishi K. Preventive effect of a second-generation silicone intraocular lens on posterior capsule opacification. J. Cataract Refract. Surg. 28:2002;1236-1240
100. Nishi O., Nishi K., Fujiwara T., Shirasawa E., Ohmoto Y. Effects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells. Br. J. Ophthalmol. 80:1996;63-68
101. Nishi O., Nishi K., Mano C., Ishihara M., Honda T. Inhibition of migrating lens epithelial cells by blocking the adhesion molecule integrin. A preliminary report. J. Cataract Refract. Surg. 23:1997;860-865
102. Nishi O., Nishi K., Wickstrom K. Preventing lens epithelial cell migration using intraocular lenses with sharp rectangular edges. J. Cataract Refract. Surg. 26:2000;1543-1549
103. Nishi O., Nishi K., Akura J., Nagata T. Effect of round-edged acrylic intraocular lenses on preventing posterior capsule opacification. J. Cataract Refract. Surg. 27:2001;608-613
104. Ohara K. Biomicroscopy of surface deposits resembling foreign-body giant cells on implanted intraocular lenses. Am. J. Ophthalmol. 226:1985;449-454
105. Ohmi S. Decentration associated with asymmetric capsular shrinkage and intraocular lens size. J. Cataract Refract. Surg. 19:1993;640-643
106. Ohnishi Y., Yoshitomi T., Sakamoto T., Fujisawa K., Ishibashi T. Evaluation of cellular adhesion on silicone and poly(methylmethacrylate) intraocular lenses in monkey eyes. An electron microscopic study. J. Cataract Refract. Surg. 27:2001;2036-2040
107. Olson R.J., Mamalis N., Werner L., Apple D.J. Cataract treatment in the beginning of the 21st century. Am. J. Ophthalmol. 136:2003;146-154
108. Oshika T., Nagata T., Ishii Y. Adhesion of lens capsule to intraocular lenses of PMMA, silicone and acrylic foldable materials. an experimental study Br. J. Ophthalmol. 82:1998;549-553
109. Pandey S.K., Ram J., Werner L., Brar G.S., Jain A.K., Gupta A., Apple D.J. Visual results and postoperative complications of capsular bag and ciliary sulcus fixation of posterior chamber intraocular lenses in children with traumatic cataracts. J. Cataract Refract. Surg. 25:1999;1576-1584
110. Picht G., Welge-Luessen U., Grehn F., Lutjen-Drecoll E. Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development. Graefes Arch. Clin. Exp. Ophthalmol. 239:2001;199-207
111. Piek E., Ju W.J., Heyer J., Escalante-Alcalde D., Stewart C.L., Weinstein M., Deng C., Kucherlapati R., Bottinger E.P., Roberts A.B. Functional characterization of transforming growth factor beta signaling in Smad-2 and Smad3-deficient fibroblasts. J. Biol. Chem. 276:2001;19945-19953
112. Proetzel G., Pawlowski S.A., Wiles M.V., Yin M., Boivin G.P., Howles P.N., Ding J., Ferguson M.W., Doetschman T. Transforming growth factor-β3 is required for secondary palate fusion. Nat. Genet. 11:1995;409-414
113. Qing J., Zhng Y., Derynck R. Structural and functional characterization of the transforming growth factor-β -induced Smad3/c-Jun transcriptional cooperatively. J. Biol. Chem. 275:2000;38802-38812
114. Rakic J.-M., Galand A., Vrensen G.F.J.M. Separation of fibers from the capsule enhances mitotic activity of human lens epithelium. Exp. Eye Res. 64:1997;67-72
115. Ram J., Pandey S.K., Apple D.J., Werner L., Brar G.S., Singh R., Chaudhary K.P., Gupta A. Effect of in-the-bag intraocular lens fixation on the prevention of posterior capsule opacification. J. Cataract Refract. Surg. 27:2001;1039-1046
116. Ravalico G., Baccara F., Lovisato A., Tognetto D. Postoperative cellular reaction on various intraocular lens materials. Ophthalmology. 104:1997;1084-1091
117. Rinaudo J.A.S., Zelenka P.S. Expression of c-fos and c-jun mRNA in the developing chicken lens. relationship to cell proliferation, quiescence, and differentiation Exp. Cell Res. 199:1992;147-153
118. Roberts A.B., Sporn M.B. The transforming growth factor-βs. Roberts A.B, Sporn M.B. Peptide Growth Factors and their Receptors I. 1990;419-472 Springer, Berlin, Heidelberg, New York
119. Roberts A.B., Sporn M.B. Differential expression of the TGF-β isoforms in embryogenesis suggests specific roles in developing and adult tissues. Mol. Reprod. Dev. 32:1992;91-98
120. Roberts A.B., Russo A., Felici A., Flanders K.C. Smad3. a key player in pathogenetic mechanisms dependent on TGF-β Ann. N. Y. Acad. Sci. 995:2003;1-10
121. Saika S. Extracellular matrix and cytokines. Front. Glaucoma. 2:2001;42-46. (in Japanese)
122. Saika S. Biocompatibility of foldable IOLs as evaluated by histopathology. IOL and RS. 16:2002;365-368. (in Japanese)
123. Saika S. Signal transduction in lens epithelial cell response. Masuda K., Oguchi Y., Tano Y., Araie M., Ogura Y., Ohshika T., Kinoshita S., Negi A., Mochizuki M., Yoneya S. Ganka No Saishin-iryou. 2003;263-269 Terada Kokusdai Jimusyo/Senta Iryougizyutu Kenkyusho, Tokyo. (in Japanese)
124. Saika, S., 2004. TGFβ signal transduction in corneal wound healing as a therapeutic target. Cornea (Suppl), in press.
125. Saika S., Kawashima Y., Miyamoto T., Okada Y., Tanaka S-I., Ohmi S., Minamide A., Yamanaka O., Ohnishi Y., Ooshima A., Yamanaka A. Immunolocalization of prolyl 4-hydroxylase subunits, α-smooth muscle actin, and extracellular matrix components in human lens capsules with lens implants. Exp. Eye Res. 66:1998;283-294
126. Saika S., Kawashima Y., Miyamoto T., Okada Y., Tanaka S., Yamanaka O., Ohnishi Y., Ooshima A., Yamanaka A. Immunolocalization of hyaluronan and CD44 in quiescent and proliferating human lens epithelial cells. J. Cataract Refract. Surg. 24:1998;1266-1270
127. Saika S., Kawashima Y., Miyamoto T., Okada Y., Tanaka S., Yamanaka O., Ohnishi Y., Ooshima A., Yamanaka A. Immunohistochemical identification of proteoglycan types in fibrotic human capsules with intraocular lens implants. Jpn. J. Ophthalmol. 42:1998;368-372
128. Saika S., Kawashima Y., Miyamoto T., Tanaka S., Okada Y., Yamanaka O., Katoh T., Ohnishi Y., Ohmi S., Ooshima A., Yamanaka A. Immunolocalization of prolyl 4-hydroxylase in rabbit lens epithelial cells. J. Cataract Refract. Surg. 24:1998;1261-1265
129. Saika S., Kobata S., Yamanaka O., Yamanaka A., Okubo K., Oka T., Hosomi M., Kano Y., Ohmi S., Uenoyama S., Tamura M., Kanagawa R., Uenoyama K. Cellular fibronectin on intraocular lenses explanted from patients. Greafes Arch. Clin. Exp. Ophthalmol. 231:1993;718-721
130. Saika S., Kono-Saika S., Ohnishi Y., Sato M., Muragaki Y., Ooshima A., Flanders K.C, Yoo J., Anzano M., Liu C.-Y., Kao W.W.-Y., Roberts A.B. Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium post-injury. Am. J. Pathol. 164:2004;651-663
131. Saika S., Miyamoto T., Kimura M., Ohmi S., Ohkwa K., Kwashima Y., Ohnishi Y., Ooshima A., Yamanaka A. Degenerated lens epithelial cells in rabbit and human eyes after intraocular lens implantation. J. Cataract Refract. Surg. 24:1998;1396-1398
132. Saika S., Miyamoto T., Yamanaka A., Kawashima Y., Okada Y., Tanaka S., Yamanaka O., Ohmi S., Ohnishi Y., Ooshima A. Immunohistochmeical evaluation of cellular deposits on posterior chamber intraocular lenses. Graefes Arch. Clin. Exp. Ophthalmol. 236:1998;758-765
133. Saika S., Miyamoto T., Kawashima Y., Okada Y., Yamanaka O., Ohnishi Y., Ooshima A. Immunolocalization of tgf-β1, -β2, and -β3, and TGF-β receptors in human lens capsules with lens implants. Graefes Arch. Clin. Exp. Ophthalmol. 238:2000;283-293
134. Saika S., Miyamoto T., Okada Y., Yamanaka O., Ohnishi Y., Ooshima A. Transforming growth factor-β isoform proteins in cell and matrix deposits on intraocular lenses. J. Cataract Refract. Surg. 26:2000;709-715
135. Saika S., Miyamoto T., Ishida I., Tanaka T., Okada Y., Nagane Y., Shirai K., Ohnishi Y. Comparison of Scheimpflug images of posterior capsule opacification and histological findings in rabbits and humans. J. Cataract Refract. Surg. 27:2001;1088-1092
136. Saika S., Miyamoto T., Tanaka T., Ishida I., Ohnishi Y., Ooshima A. Latent TGFβ binding protein-1 and fibrillin-1 in human capsular opacification and in cultured lens epithelial cells. Br. J. Ophthalmol. 85:2001;1362-1366
137. Saika S., Miyamoto T., Tanaka T., Ishida I., Ohnishi Y., Ooshima A. Collagens XII and XIV (FACITs) in capsular opacification and in cultured lens epithelial cells. Curr. Eye Res. 23:2001;463-468
138. Saika S., Miyamoto T., Ishida I., Ohnish Y., Ooshima A. Lens epithelial cell death after cataract surgery. J. Cataract Refract. Surg. 28:2002;1452-1456
139. Saika S., Miyamoto T., Ishida I., Shirai K., Ohnishi Y., Ooshima A., McAvoy J.W. TGFβ/Smad signalling in postoperative human lens epithelial cells. Br. J. Ophthalmol. 86:2002;1428-1433
140. Saika S., Miyamoto T., Ishida I., Ohnishi Y., Ooshima A. Osteopontin. a component of matrix in capsular opacification and subcapsular cataract Invest. Ophthalmol. Vis. Sci. 44:2003;1622-1628
141. Saika S., Miyamoto T., Ohnishi Y. Histology of anterior capsule opacification with a polyHEMA/HOHEXMA hydrophilic hydrogel intraocular lens compared to poly(methyl methacrylate), silicone, and acrylic lenses. J. Cataract Refract. Surg. 29:2003;1198-1203
142. Saika S., Miyamoto T., Tanaka S., Tanaka T., Ishida I., Ohnishi Y., Ooshima A., Ishiwata T., Asano G., Chikama T., Shiraishi A., Liu C.Y., Kao C.W., Kao W.W. Response of lens epithelial cells to injury. role of lumican in epithelial-mesenchymal transition Invest. Ophthalmol. Vis. Sci. 44:2003;2094-2102
143. Saika S., Ohmi S., Kanagawa R., Tanaka S., Ohnishi Y., Ooshima A., Yamanaka A. Lens epithelial cell outgrowth and matrix formation on intraocular lenses in rabbit eyes. J. Cataract Refract. Surg. 22:1996;835-840
144. Saika S., Ohmi S., Kimura T., Okada Y., Tanaka S., Ohnishi Y., Ymanaka O., Ooshima A. Electron microscopic observation on the posterior lens capsule after implantation of a silicone intraocular lens in rabbits. J. Jpn Ophthalmol. Soc. 100:1996;687-691
145. Saika S., Ohmi S., Ooshima A., Kimura M., Tanaka S., Okada Y., Ohnishi Y., Yamanaka A. Deposition of extracellular matrix on silicone intraocular lens implants in rabbits. Graefes Arch. Clin. Exp. Ophthalmol. 235:1997;517-522
146. Saika S., Ohnishi Y., Ooshima A., Liu C.Y., Kao W.W.-Y. Epithelial repair. roles of extracellular matrix Cornea. 21:2002;S23-S29
147. Saika S., Okada Y., Miyamoto T., Ohnishi Y., Ooshima A., McAvoy J.W. Smad translocation and growth suppression in lens epithelial cells by endogenous TGFβ2 during wound repair. Exp. Eye Res. 76:2001;679-686
148. Saika S., Ooshima A., Yamanaka O., Tanaka S., Okada Y., Hashizume N., Ohnishi Y. Effect of a prolyl hydroxylase inhibitor on rabbit ocular fibroblasts. Ophthalmic Res. 27:1995;335-346
149. Saika S., Ooshima A., Yamanaka O., Okada Y., Tanaka S., Ohnishi Y. Effect of fibrostatin C, an inhibitor of prolyl 4-hydroxylase, on collagen secretion by human tenon's capsule fibroblasts in vitro. Graefes Arch. Clin. Exp. Ophthalmol. 234(Suppl 1):1996;S214-S222
150. Saika S., Saika S., Liu C.Y., Azhar M., Sanford L.P., Doetschman T., Gendron R.L., Kao C.W., Kao W.W. TGFβ2 in corneal morphogenesis during mouse embryonic development. Dev. Biol. 240:2001;419-432
151. Saika S., Shiraishi A., Liu C.Y., Funderburgh J.L., Kao C.W., Converse R.L., Kao W.W. Role of lumican in the corneal epithelium during wound healing. J. Biol. Chem. 275:2000;2607-2612
152. Saika S., Tonoe O., Kanagawa R., Uenoyama K., Yamanaka A., Fukuda K., Iwane H. Immunohistochmeical study of deposits on intraocular lenses explanted from huma eyes. Jpn J. Ophthalmol. 35:1991;96-101
153. Saika S., Tamura M., Nakao T., Kanagwa R., Uenoyama K., Hiraoka J. Experimental study of phagocytic activity of cells observed on implanted intraocular lenses. Eur. J. Implant. Refract Surg. 3:1991;87-93
154. Saika S., Tamura M., Uenoyama K., Yamanaka A., Ohkubo K., Fukuda K., Iwane H. Collagenous deposits on explanted intraocular lenses. J. Cataract Refract. Surg. 18:1992;195-199
155. Saika S., Tanaka S., Ohmi S., Minamide A., Ohnishi Y., Yamanaka A., Ooshima A., Kimura M. Deposition of extracellular matrix on intraocular lenses in rabbits. an immunohistochemical and transmission electron microscopic study Graefes Arch. Clin. Exp. Ophthalmol. 235:1997;241-247
156. Saika S., Yamanaka A., Tanaka S., Ohmi S., Ohnishi Y., Ooshima A. Extracellular matrix on intraocular lenses. Exp. Eye Res. 61:1995;713-721
157. Sanford L.P., Ormsby I., Gittenberger-deGroot A.C., Sariola H., Friedman R., Boivin G.P., Cardell E.L., Doetschman T. TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development. 124:1997;2659-2670
158. Sato M., Muragaki Y., Saika S., Roberts A.B., Ooshima A. Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J. Clin. Invest. 112:2003;1486-1494
159. Scaffidi A.K., Moodley Y.P., Weichselbaum M., Thompson P.J., Knight D.A. Regulation of human lung fibroblast phenotype and function by vitronectin and vitronectin integrins. J. Cell Sci. 114:2001;3507-3516
160. Schauersberger J., Amon M., Kruger A., Abela C., Schild G., Kolodjaschna J. Lens epithelial cell outgrowth on 3 types of intraocular lenses. J. Cataract Refract. Surg. 27:2001;850-854
161. Schauersberger J., Amon M., Kruger A., Abela C., Schild G., Kolodjaschna J. Comparison of the biocompatibility of 2 foldable intraocular lenses with sharp optic edges. J. Cataract Refract. Surg. 27:2001;1579-1585
162. Serini G., Bochaton-Piallat M.L., Ropraz P., Geinoz A., Borsi L., Zardi L., Gabbiani G. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-β1. J. Cell Biol. 142:1998;873-881
163. Serini G., Gabbiani G. Mechanisms of myofibroblast activity and phenotypic modulation. Exp. Cell Res. 250:1999;273-283
164. Shirai K., Okada Y., Saika S., Senba E., Ohnishi Y. Expression of transcription factor AP-1 in rat lens epithelial cells during wound repair. Exp. Eye Res. 73:2001;461-468
165. Shull M.M., Ormsby I., Kier A.B., Pawlowski S., Diebold R.J., Yin M., Allen R., Sidman C., Proetzel G., Calvin D. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature. 22(359):1992;693-699
166. Siegel P.M., Massague J. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nature Rev. Cancer. 3:2003;807-820
167. Spalton D.J. Posterior capsular opacification after cataract surgery. Eye. 13(Part 3b):1999;489-492
168. Spalton D.J. Methods of quantifying posterior capsule opacification. J. Cataract Refract. Surg. 29:2003;1247. (reply 1247-1248)
169. Srinivasan Y., Lovicu F.J., Overbeek P.A. Lens-specific expression of transforming growth factor β1 in transgenic mice causes anterior subcapsular cataracts. J. Clin. Invest. 101:1998;625-634
170. Sue Menko A. Lens epithelial cell differentiation. Exp. Eye Res. 75:2002;485-490
171. Tanaka, S. -I., Saika, S., Tamura, M., Ohnishi, Y., 2004. Histological observation of complete closure of anterior capsulotomy in two cases. J. Cataract Refract. Surg., in press.
172. Tehrani M., Dick H.B., Wolters B., Pakula T., Wolf E. Material properties of various intraocular lenses in an experimental study. Ophthalmologica. 218:2004;57-63
173. Teichmann K.D. Biocompatibility. J. Cataract Refract. Surg. 29:2003;1470
174. ten Dijke P., Goumans M.J., Itoh F., Itoh S. Regulation of cell proliferation by Smad proteins. J. Cell Physiol. 191:2002;1-16
175. Thiery J.P. Epithelial-mesenchynal transition in development and pathologies. Curr. Opin. Cell Biol. 15:2003;740-746
176. Tomasek J., Gabbiani G., Hinz B., Chaponnier C., Brown R.A. Myofibroblasts and mechanoregulation of connective tissue remodeling. Nature Rev. Mol. Cell Biol. 3:2002;349-363
177. Tripathi R.C., Li J., Chan W.F., Tripathi B.J. Aqueous humor in glaucomatous eyes contains an increased level of TGF-β2. Exp. Eye Res. 59:1994;723-727
178. Trivedi R.H., Werner L., Apple D.J., Pandey S.K., Izak A.M. Post cataract-intraocular lens (IOL) surgery opacification. Eye. 16:2002;217-241
179. Uenoyama K., Matoba M., Kanagawa R., Enomoto Y., Tamura M., Ohmi S. Experimental intraocular lens implantation in the rabbit eye and in the mouse peritonela space. Part I. cellular components observed on the implanted lens surface J. Cataract Refract. Surg. 14:1988;192-196
180. Ursell P.G., Spalton D.J., Pande M.V., Hollick E.J., Barman S., Boyce J., Tilling K. Relationship between intraocular lens biomaterials and posterior capsule opacification. J. Cataract Refract. Surg. 24:1998;352-360
181. Valdes F., Alvarez A.M., Locascio A., Vega S., Herrera B., Fernandez M., Benito M., Nieto M.A., Fabregat I. The epithelial-mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor beta in fetal rat hepatocytes. Mol. Cancer Res. 1:2002;68-78
182. Van Obberghen-Schilling E., Roche N.S., Flanders K.C., Sporn M.B., Roberts A.B. Transforming growth factor β1 positively regulates its own expression in normal and transformed cells. J. Biol. Chem. 263:1988;7741-7746
183. Van Tenten Y., Schuitmaker H.J., De Groot V., Willekens B., Vrensen G.F., Tassignon M.J. A preliminary study on the prevention of posterior capsule opacification by photodynamic therapy with bacteriochlorin A in rabbits. Ophthalmic Res. 34:2002;113-118
184. Verrecchia F., Mauviel A. Transforming growth factor-β signaling through the Smad pathway. role in extracellular matrix gene expression and regulation J. Invest. Dermatol. 118:2002;211-215
185. Wallentin N., Wickstrom K., Lundberg C. Effect of cataract surgery on aqueous TGF-β and lens epithelial cell proliferation. Invest. Ophthalmol. Vis. Sci. 39:1998;1410-1418
186. Wang Y., He H., Zigler J.S. Jr., Iwata T., Ibaraki N., Reddy V.N., Carper D. bFGF suppresses serum-deprivation-induced apoptosis in a human lens epithelial cell line. Exp. Cell Res. 249:1999;123-130
187. Weinstein M., Yang X., Li C., Xu X., Gotay J., Deng C.X. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor Smad2. Proc. Natl. Acad. Sci. USA. 95:1998;9378-9383
188. Werner L., Apple D.J., Escobar-Gomez M., Ohrstrom A., Crayford B.B., Bianchi R., Pandey S.K. Postoperative deposition of calcium on the surfaces of a hydrogel intraocular lens. Ophthalmology. 107:2000;2179-2185
189. Werner L., Apple D.J., Kaskaloglu M., Pandey S.K. Dense opacification of the optical component of a hydrophilic intraocular lens. a clinicopathological analysis of 9 explanted lenses J. Cataract Refract. Surg. 27:2001;1485-1492
190. Werner L., Pandey S.K., Apple D.J., Escobar-Gomez M., McLendon L., Macky T.A. Anterior capsule opacification. correlation of pathologic findings with clinical sequelae Ophthalmology. 108:2001;1675-1681
191. Werner L., Pandey S.K., Escobar-Gomez M., Visessook N., Peng Q., Apple D.J. Anterior capsule opacification. a histopathological study comparing different IOL styles Ophthalmology. 107:2000;463-471
192. Wolter J.R. Cell life on the surface of lens implants. Graefes Arch Clin Exp. Ophthalmol. 218:1982;244-249
193. Wolter J.R. Cytopathology of intraocular lens implantation. Ophthalmology. 92:1985;135-142
194. Wong C., Rougier-Chapman E.M., Frederick J.P., Datto M.B., Liberati N.T., Li J.M., Wang X.F. Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta. Mol. Cell Biol. 19:1999;1821-1830
195. Wormstone I.M. Posterior capsule opacification. a cell biological perspective Exp. Eye Res. 74:2002;337-347
196. Wormstone I.M., Tamiya S., Marcantonio J.M., Reddan J.R. Hepatocyte growth factor function and c-Met expression in human lens epithelial cells. Invest. Ophthalmol. Vis. Sci. 41:2000;4216-4222
197. Wormstone I.M., Tamiya S., Anderson I., Duncan G. TGF-β2-induced matrix modification and cell transdifferentiation in the human lens capsular bag. Invest. Ophthalmol. Vis. Sci. 43:2002;2301-2308
198. Wrana J.L., Attisano L., Wieser R., Ventura F., Massague J. Mechanism of activation of the TGF-β receptor. Nature. 370:1994;341-347
199. Yamanaka A., Miyake K., Nakamae K., Tamai M., Inatomi M., Yamamoto T., Sawa M., Ishibashi T., Ohshika T., Eguchi S., Saika S. Epitome and operation report of committee for intraocular lens implant data system. The 7th Report (2002). IOL and RS (2003). 17:2002;139-145. (in Japanese)
200. Yamashita T., Yoshioka M., Itoh N. Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem. Biophys. Res. Commun. 277:2000;494-498
201. Yang X., Letterio J.J., Lechleider R.J., Chen L., Hayman R., Gu H., Roberts A.B., Deng C. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-β EMBO J. 18:1999;1280-1291
202. Yang Y.C., Piek E., Zavadil J., Liang D., Xie D., Heyer J., Pavlidis P., Kucherlapati R., Roberts A.B., Bottinger E.P. Hierarchical model of gene regulation by transforming growth factor β Proc. Natl. Acad. Sci. USA. 100:2003;10269-10274
203. Yates S., Rayner T.E. Transcription factor activation in response to cutaneous injury. role of AP-1 in reepithelialization Wound Repair Regen. 10:2002;5-15
204. Zaczek A., Zetterstrom C. Posterior capsule opacification after phacoemulsification in patients with diabetes mellitus. J. Cataract Refract. Surg. 25:1999;233-237
205. Zeisberg M., Hanai J., Sugimoto H., Mammoto T., Charytan D., Strutz F., Kalluri R. BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat. Med. 9:2003;964-968
206. Zhao S., Overbeek P.A. Elevated TGFβ signaling inhibits ocular vascular development. Dev. Biol. 237:2001;45-53