Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice

Journal of Biological Chemistry

Volumn 278, Issue 27, 2003, Pages 25109-25119

  Denton, Christopher P ^a   Zheng, Bing ^b   Evans, Lowri A ^a   Shi Wen, Xu ^a   Ong, Voon H ^a   Fisher, Ivan ^a   Lazaridis, Konstantinos ^c   Abraham, David J ^a   Black, Carol M ^a   De Crombrugghe, Benoit ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMARKERS; CELLS; CLONING; DNA; TISSUE;

MICROARRAYS;

ENZYMES;

CONNECTIVE TISSUE GROWTH FACTOR; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; COLLAGEN GENE; DNA MICROARRAY; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROSIS; GENE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REPORTER GENE; SKIN CELL; TRANSGENIC MOUSE; VASCULARIZATION; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALIA; MUS MUSCULUS;

ANIMALS; DISEASE MODELS, ANIMAL; FIBROBLASTS; FIBROSIS; MICE; MICE, TRANSGENIC; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0042090396     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300636200     Document Type: Article

References (61)

1. Bottinger, E. P., Letterio, J. J., and Roberts, A. B. (1997) Kidney Int. 51, 1355-1360
2. Oshima, M., Oshima, H., and Taketo, M. M. (1996) Dev. Biol. 179, 297-302
3. Annes, J. P., Munger, J. S., Rifkin, D. B. (2003) J. Cell Sci. 116, 217-224
4. Crawford, S. E., Stellmach, V., Murphy-Ullrich, J. E., Ribeiro, S. M., Lawler, J., Hynes R. O., Boivin, G. P., and Bouck, N. (1998) Cell 93, 1159-1170
5. Hocevar, B. A., Brown, T. L., and Howe, P. H. (1999) EMBO J. 18, 1345-1356
6. Ravanti, L., Hakkinen, L., Larjava, H., Saarialho-Kere, U., Foschi, M., Han, J., Kahari, V. M. (1999) J. Biol. Chem. 27, 37292-37300
7. Rosado, E., Schwartz, Z., Sylvia, V. L., Dean, D. D., and Boyan, B. D. (2002) Biochim. Biophys. Acta 1590, 1-15
8. Bou-Gharios, G., Garrett, L. A., Rossert, J., Niederreither, K., Eberspaecher, H., Smith, C., Black, C., and de Crombrugghe, B. (1996) J. Cell Biol. 134, 1333-1344
9. Denton, C. P., Zheng, B., Shi-wen, X., Bou-Gharios, G., Zhang, Z., Eberspaecher, H., Black, C. M., and de Crombrugghe, B. (2001) Arthritis Rheum. 44, 712-722
10. Weis-Garcia, F., and Massague, J. (1996) EMBO J. 15, 276-289
11. Brandt, T., MacLenan, W. R., and Schneider, M. D. (1993) J. Biol. Chem. 268, 11500-11503
12. Schmidt, A., Rossi, P., and de Crombrugghe, B. (1986) Mol. Cell. Biol. 6, 347-354
13. Mercer, E. H., Hoyle, G. W., Kapur, R. P., Brinster, R. L., and Palmiter, R. D. (1991) Neuron 7, 703-716
14. Kim, D. G., Kang, H. M., Jang, S. K., and Shin, H. S. (1992) Mol. Cell. Biol. 12, 3636-3643
15. Hogan, B., Costantini, F., and Lacy, E. (1980) Manipulating the Mouse Embryo: A Laboratory Manual, pp. 497-500, Cold Spring Harbor, NY
16. Labarca, C., and Paigen, K. (1980) Anal. Biochem. 102, 344-352
17. Kuznetsova, N., and Leikin, S. (1999) J. Biol. Chem. 274, 36083-36088
18. Li, Y. Y., Feng, Y. Q., Kadokami, T., McTiernan, C. F., Draviam, R., Watkins, S. C., and Feldman, A. M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 12746-12751
19. Young, R. A. (2000) Cell 102, 9-15
20. Kaminski, N., Allard, J. D., Pittet, J. F., Zuo, F., Griffiths, M. J., Morris, D., Huang, X., Sheppard, D., and Heller, R. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1778-1783
21. Smith, J. D., Bryant, S. R., Couper, L. L., Vary, C. P., Gotwals, P. J., Koteliansky, V. E., and Lindner, V. (1999) Circ. Res. 84, 1212-1222
22. Abe, M., Harpel, J. G., Metz, C. N., Nunes, I., Loskutoff, D. J., and Rifkin, D. B. (1994) Anal. Biochem. 216, 276-284
23. Chipuk, J. E., Cornelius, S. C., Pultz, N. J., Jorgensen, J. S., Bonham, M. J., Kim, S. J., and Danielpour, D. (2002) J. Biol. Chem. 277, 1240-1248
24. Wong, S. H., Hamel, L., Chevalier, S., and Philip, A. (2000) Eur. J. Biochem. 267, 5550-5560
25. Barbara, N. P., Wrana, J. L., Letarte, M. (1999) J. Biol. Chem. 274, 584-594
26. Onichtchouk, D., Chen, Y. G., Dosch, R., Gawantka, V., Delius, H., Massague, J., and Niehrs, C. (1999) Nature 401, 480-485
27. Wang, X. J., Greenhalgh, D. A., Bickenbach, J. R., Jiang, A., Bundman, D. S., Krieg, T., Derynck, R., and Roop, D. R. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2386-2391
28. Go, C., Li, P., and Wang, X. J. (1999) Cancer Res. 59, 2861-2868
29. Bottinger, E. P., Jakubczak, J. L., Roberts, I. S., Mumy, M., Hemmati, P., Bagnall, K., Merlino, G., and Wakefield, L. M. (1997) EMBO J. 16, 2621-2633
30. Hahm, K. B., Im, Y. H., Lee, C., Parks, W. T., Bang, Y. J., Green, J. E., and Kim, S. J. (2000) J. Clin. Invest. 105, 1057-1065
31. Serra, R., Johnson, M., Filvaroff, E. H., LaBorde, J., Sheehan, D. M., Derynck, R., and Moses H. L. (1997) J. Cell Biol. 139, 541-552
32. Filvaroff, E., Erlebacher, A., Ye, J., Gitelman, S. E., Lotz, J., Heillman, M., and Derynck, R. (1999) Development 126, 4267-4279
33. Joseph, H., Gorska, A. E., Sohn, P., Moses, H. L., and Serra, R. (1999) Mol. Biol. Cell 10, 1221-1234
34. Gorska, A. E., Joseph, H., Derynck, R., Moses, H. L., and Serra, R. (1998) Cell Growth Differ. 9, 229-238
35. Kundu, S. D., Kim, I. Y., Yang, T., Doglio, L., Lang, S., Zhang, X., Buttyan, R., Kim, S. J., Chang, J., Cai, X., Wang, Z., and Lee, C. (2000) Prostate 43, 118-124
36. Kanzler, S., Meyer, E., Lohse, A. W., Schirmacher, P., Henninger, J., Galle, P. R., and Blessing, M. (2001) Oncogene 20, 5015-5024
37. de Iongh, R. U., Lovicu, F. J., Overbeek, P. A., Schneider, M. D., Joya, J., Hardeman, E. D., McAvoy, J. W. (2001) Development 128, 3995-4010
38. Hahm, K. B., Lee, K. M., Kim, Y. B., Hong, W. S., Lee, W. H., Han, S. U., Kim, M. W., Ahn, B. O., Oh, T. Y., Lee, M. H., Green, J., and Kim, S. J. (2002) Aliment Pharmacol Ther. 16, Suppl. 2, 115-127
39. Lucas, P. J., Kim, S. J., Melby, S. J., Gress, R. E. (2000) J. Exp. Med. 191, 1187-1196
40. Schramm, C., Protschka, M., Kohler, H. H., Podlech, J., Reddehase, M. J., Schirmacher, P., Galle, P. R., Lohse, A. W., and Blessing, M. (2003) Am. J. Physiol. 284, G525-G535
41. Zhu, H. J., and Burgess, A. W. (2001) Mol. Cell. Biol. Res. Commun. 4, 321-330
42. Kavsak, P., Rasmussen, R. K., Causing, C. G., Bonni, S., Zhu, H., Thomsen, G. H., and Wrana, J. L. (2000) Mol. Cell 6, 1365-1375
43. Yang, Y. A., Dukhanina, O., Tang, B., Mamura, M., Letterio, J. J., MacGregor, J., Patel, S. C., Khozin, S., Liu, Z. Y., Green, J., Anver, M. R., Merlino, G., and Wakefield, L. M. (2002) J. Clin. Invest. 109, 1607-1615
44. Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S., Gotwals, P. J., Koteliansky, V., and Arteaga, C. L. (2002) J. Clin. Invest. 109, 1551-1559
45. Dong, C., Zhu, S., Wang, T., Yoon, W., Li, Z., Alvarez, R. J., ten Dijke, P., White, B., Wigley, F. M., and Goldschmidt-Clermont, P. J. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 3908-3913
46. Simms, R. W., and Korn, J. H. (2002) Curr. Opin. Rheumatol. 14, 717-722
47. Denton, C. P., and Abraham, D. J. (2001) Curr. Opin. Rheumatol. 13, 505-511
48. Kawakami, T., Ihn, H., Xu, W., Smith, E., LeRoy, C., and Trojanowska, M. (1998) J. Invest. Dermatol. 110, 47-51
49. Ihn, H., Yamane, K., Kubo, M., Tamaki, K. (2001) Arthritis Rheum. 44, 474-480
50. Yamane, K., Ihn, H., Kubo, M., Tamaki, K. (2002) Arthritis Rheum. 46, 2421-2428
51. Leask, A., Abraham, D. J., Finlay, D. R., Holmes, A., Pennington, D., Shi-Wen, X., Chen, Y., Venstrom, K., Dou, X., Ponticos, M., Black, C., Bernabeu, C., Jackman, J. K., Findell, P. R., and Cannolly, M. K. (2002) Arthritis Rheum. 46, 1857-1865
52. Querfeld, C., Eckes, B., Huerkamp, C., Krieg, T., Sollberg, S. (1999) J. Dermatol. Sci. 21, 13-22
53. Coker, R. K., Laurent, G. J., Jeffery, P. K., du Bois, R. M., Black, C. M., and McAnulty, R. J. (2001) Thorax 56, 549-556
54. Lane, K. B., Machado, R. D., Panciulo, M. W., Thomson, J. R., Phillips, J. A., Loyd, J. E., Nichols, W. C., and Trembath, R. C. (2000) Nat. Genet. 26, 81-84
55. Thomson, J. R., Machado, R. D., Pauciulo, M. W., Morgan, N. V., Humbert, M., Elliott, G. C., Ward, K., Yacoub, M., Mikhail, G., Rogers, P., Corris, P., Humbert, M., Donnai, D., Martensson, G., Tranebjaerg, L., Loyd, J. E., Trembath, R. C., and Nichols, W. C. (2000) J. Med. Genet. 37, 741-745
56. Morrell, N. W., Yang, X., Upton, P. D., Jourdan, K. B., Morgan, N, Sheares, K. K., and Trembath, R. C. (2001) Circulation 104, 790-795
57. Rudarakanchana, N., Flanagan, J. A., Chen, H., Upton, P. D., Machado, R., Patel, D., Trembath, R. C., and Morrell, N. W. (2002) Hum. Mol. Genet. 11, 1517-1525
58. Morse, J., Barst, R., Horn, E., Cuervo, N., Deng, Z., and Knowles, J. (2002) J. Rheumatol. 29, 2379-2381
59. Tew, M. B., Arnett, F. C., Reveille, J. D., and Tan, F. (2002) Arthritis Rheum. 46, 2829-2830
60. Coghlan, J. G., and Mukerjee, D. (2001) Curr. Opin. Rheumatol. 13, 495-499
61. Zhang, Y, McCormick, L. L., Desai, S. R., Wu, C., and Gilliam, A. C. (2002) J. Immunol. 168, 3088-3098