Lens-specific expression of transforming growth factor β1 in transgenic mice causes anterior subcapsular cataracts

Journal of Clinical Investigation

Volumn 101, Issue 3, 1998, Pages 625-634

  Srinivasan, Y ^a,b   Lovicu, F J ^a,c   Overbeek, P A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cataracts; Cornea; Lens; TGF ; Transgenic mice

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATARACT; CORNEA EPITHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

EID: 0032006610     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1360     Document Type: Article

References (53)

1. Roberts, A.B., and M.B. Sporn. 1990. The transforming growth factor-βs. In Growth Factors and Their Receptors. Handbook of Experimental Pharmacology. A.B. Roberts and M.B. Sporn, editors. Springer-Verlag, Heidelberg. 419-472.
2. Derynek, R., 1994. TGF-β-receptor mediated signaling. Trends Biochem. Sci. 20:548-553.
3. Derynck, R., 1994. The biological complexity of transforming growth factor β. In The Cytokine Handbook. 2nd ed. A. Thompson, editor. Academic Press, Inc., New York. 319-342.
4. Ohta, M., J.S. Greenburg, P. Ankelesaria, A. Bassols, and J. Massague. 1987. Two forms of transforming growth factor β distinguished by multipotential haematopoietic progenitor cells. Nature. 329:539-542.
5. Gentry, L.E., N.R. Webb, G.J. Lim, A.M. Brunner, J.E. Ranchalis, D.R. Twardzik, M.N. Lioubin, H. Marquardt, and A.F. Purchio. 1987. Type 1 transforming growth factor β: amplified expression and secretion of mature and precursor polypeptides in Chinese hamster ovary cells. Mol. Cell Biol. 7:3418-3427.
6. Sato, Y., R. Tsuboi, R. Lyons, H. Moses, and D.B. Rifkin. 1990. Characterization of the activation of latent TGF-β by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system. J. Cell Biol. 111: 757-763.
7. Lyons, R.M., L.E. Gentry, A.F. Purchio, and H.L. Moses. 1990. Mechanism of activation of latent recombinant transforming growth factor β1 by plasmin. J. Cell Biol. 110:1361-1367.
8. Wrana, J.L., L. Attisano, R. Wieser, F. Ventura, and J. Massague. 1994. Mechanism of activation of the TGF-β receptor. Nature. 370:341-347.
9. Massague, J. 1996. TGF-β signaling: receptors, transducers, and Mad proteins. Cell. 85:947-950.
10. Montesano, R., and L. Orci. 1988. Transforming growth factor β stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc. Natl. Acad. Sci. USA. 85:4894-4897.
11. Chamberlain, C.G., and J.W. McAvoy. 1997. Fiber differentiation and polarity in the mammalian lens. A key role for FGF. Prog. Ret. Eye Res. 16:443-478.
12. Pasquale, R.L., M.L. Dorman-Pease, G.A. Lutty, H.A. Quigley, and H.D. Jampel. 1993. Immunolocalization of TGF-β1, TGF-β2, and TGF-β3 in the anterior segment of the human eye. Investig. Ophthalmol. Vis. Sci. 34:23-30.
13. Pelton, R.W., B. Saxena, M. Jones, H.L. Moses, and L.I. Gold. 1991. Immunohistochemical localization of TGF-β1, TGF-β2 and TGF-β3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J. Cell Biol. 115:1091-1105.
14. Lutty, G., K. Ikeda, C. Chandler, and D.S. McLeod. 1991. lmmunohistochemical localization of transforming growth factor β in human photoreceptors. Curr. Eye Res. 10:61-74.
15. Cousins, S.W., M.M. McCabe, D. Danielpour, and J.W. Streilein. 1991. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Investig. Ophthalmol. Vis. Sci. 32:2201-2211.
16. Millan, F.A., F. Denhez, P. Kondaiah, and R.J. Akhurst. 1991. Embryonic gene expression patterns of TGFβ, β2 and β3 suggest different developmental functions in vivo. Development (Camb.). 111:131-144.
17. Dudley, A.T., K.M. Lyons, and E.J. Robertson. 1995. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 9:2795-2807.
18. Luo, G., C. Hofmann, A.L. Bronckers, M. Sohocki, A. Bradley, and G. Karsenty. 1995. BMP-7 is an inducer of nephrogenesis. and is also required for eye development and skeletal patterning. Genes Dev. 9:2808-2820.
19. Sanford, P.L., I. Ormsby, A.C. Gittenberger-de-Groot, H. Sariola, R. Friedman, G.P. Bolvin, E.L. Cardell, and T. Doetschman. 1997. TGF-β2 knockout mice have multiple developmental defects that are non-overlapping with other TGF-β knockout phenotypes. Development (Camb.). 124:2659-2670.
20. Font, R.L., and S. Brownstein. 1974. A light and electron microscopic study of anterior capsular cataracts. Am. J. Ophthalmol. 78:972-984.
21. Novotny, G.E.K., and H. Pau. 1984. Myofibroblast-like cells in human anterior capsular cataract. Virchows Arch. A. Pathol. Anat. Histopathol. 404: 393-401.
22. Green, W.R., and P.J. McDonnell 1985. Opacification of the posterior capsule. Trans. Ophthalmol. Soc. UK. 104:727-739.
23. Worgul, B.V. 1993. Lens. In Biomedical Foundations of Ophthalmology. Vol. 15. T.D. Duane and E. Jaeger, editors. Harper & Row. Philadelphia. 1-15.
24. Hales, A.M., C.G. Chamberlain, and J.W. McAvoy. 1995. Cataract induction in lenses cultured with transforming growth factor-β. Investig. Ophthalmol. Vis. Sci. 36:1709-1713.
25. Liu, J., A. Hales, C.G. Chamberlain, and J.W. McAvoy. 1994. Induction of cataract-like changes in rat lens epithelial expiants by transforming growth factor β. Investig. Ophthalmol. Vis. Sci. 35:388-401.
26. Arrick, B.A., A.R. Lopez, F. Elfman, R. Ebner, C.H. Damsky, and R. Derynck. 1992. Altered metabolic and adhesive properties and increased tumorigenesis associated with the increased expression of transforming growth factor β1, J. Cell Biol. 118:715-726.
27. Brunner, A.M., H. Marquardt, A.R. Malacko, M.N. Lioubin, and A.F. Purchio. 1989. Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor β1 precursor. Expression and characterization of mutant proteins. J. Biol. Chem. 264:13660-13664.
28. Reneker, L.W., D.W. Silversides. K. Patel, and P.A. Overbeek. 1995. TGF-α can act as a chemoattractant to perioptic mesenchymal cells in developing mouse eyes. Development (Camb.). 121:1669-1680.
29. Overbeek, P.A., A.B. Cheplinsky, J.S. Khillan, J. Piatigorsky, and H. Westphal. 1985. Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc. Natl. Acad. Sci. USA. 82:7815-7819.
30. Gorman, C.F., L.F. Moffat, and B.H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
31. Taketo, M., A.C. Schroeder, L.E. Mobraaten, K.B. Gunning, G. Hanten, R.R. Fox, T.H. Roderich, C.L. Stewart, F. Lilly, C.T. Hansen, and P.A. Overbeek. 1991. FVB/N: an inbred mouse strain preferable for transgenic analysis. Proc. Natl. Acad. Sci. USA. 88:2065-2069.
32. Hogan, B., R. Beddington, F. Constantini, and E. Lacy. 1994. Manipulating the Mouse Embryo: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory. Cold Spring Harbor. NY.
33. Robinson, M.L., P.A. Overbeek, D.J. Verran, W.E. Grizzle. C.R. Stockard, R. Friesel, T. Maciag, and J.A. Thompson. 1995. Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice. Development (Camb.). 121: 505-514.
34. Qian, S.W., P. Kondaiah, A.B. Roberts, and M.B. Sporn. 1990. Cloning of a rat TGF-β1 cDNA. Nucleic. Acids Res. 18:3059.
35. Suzuki, A., N. Shioda, T. Maeda, M. Tada, and N. Ueno. 1994. A mouse TGF-β type I receptor that requires type II receptor for ligand binding. Biochem. Biophys. Res. Commun. 198:1063-1069.
36. Suzuki, A., N. Shioda, T. Maeda. M. Tada, and N. Ueno. 1994. Cloning of an isoform of mouse TGF-β type II receptor gene. FEBS (Fed. Eur. Biochem. Soc.) Lett. 355:19-22.
37. Fromm, L., W. Shawlot, K. Gunning, J.S. Butel, and P.A. Overbeek. 1994. The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice. Mol Cell. Biol. 14: 6743-6754.
38. Schmitt-Graff, A., H. Pau, R. Spahr, H.M. Piper, O. Skalli, and G. Gabhiani. 1990. Appearance of alpha-smooth muscle actin in human eye lens cells of anterior eapsular cataract and in cultured bovine lens-forming cells. Differentiation. 43:115-122.
39. Gavrieli, Y., Y. Sherman, and S.A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragments. J. Cell Biol. 119:493-501.
40. Hales, A.M., M.W. Schulz, C.G. Chamberlain, and J.W. McAvoy. 1994. TGF-β1 induces lens cells to accumulate α-smooth muscle actin, a marker for subcapsular cataracts. Curr. Eye Res. 13:885-890.
41. Nishida, K., C. Sotozono, W. Adachi, S. Yamamoto, N. Yokoi, and S. Kinoshita. 1995. Transforming growth factor β-1. β-2 and β-3 mRNA express in human cornea. Curr. Eye Res. 14:235-241.
42. Mishima, H., M. Nakamura, J. Murakami, T. Nishida, and T. Otori, 1992. Transforming growth factor β modulates effects of epidermal growth factor in corneal epithelial cells. Curr. Eye Res. 11:691-696.
43. Tseng, S., J. Merritt, F. Ding, and D. Li. 1993. Mechanism of TGF-β paradox in epithelial growth. Investig. Ophthalmol. Vis. Sci. 34:1302-1310.
44. de Iongh, R.U., C. Gordon-Thomson, C.G. Chamberlain, and J.W. McAvoy. 1996. Age related competence of TGF-β response in rat lens epithelium correlates with receptor expression. Investig. Ophthalmol. Vis. Sci. 37: S983. (Abstr.)
45. Jampel. H.D., N. Roche, W.J. Starks, and A.B. Roberts. 1990. Transforming growth factor-β in human aqueous humor. Curr. Eye Res. 9:963-969.
46. Connor, T.B., A.B. Roberts, M.B. Sporn, D. Danielpour, L.L. Dart, R.G. Michels, S. de Bustros, C. Enger, H. Kato, M. Lansing, et al. 1989. Correlation of fibrosis and transforming growth factor-β type 2 levels in the eye. J. Clin. Invest. 83:1661-1666.
47. Helbig, H., K.L. Kittredge, M. Coca-Prados, J. Davis, A.G. Palestine, and R.B. Nussenblatt. 1991. Mammalian ciliary body epithelial cells in culture produce transforming growth factor beta. Graefe's Arch. Clin. Exp. Ophthalmol. 229:84-87.
48. Knisely, T.L., P.A. Bleicher, C.A. Vibbard, and R.D. Granstein. 1991. Production of latent transforming growth factor beta and other inhibitory factors by cultured murine iris and ciliary body cells. Curr. Eye Res. 10:761-771.
49. Wahl, S.M., D.A. Hunt, L.M. Wakefield, N. McCartney-Francis, L.M. Wahl, A.B. Roberts, and M.B. Sporn. 1987. Transforming growth factor type β induces monocyte chemotaxis and growth factor production. Proc. Natl. Acad. Sci. USA. 84:5788-5792.
50. Roberts, A.B., and M.B. Sporn. 1993. A major advance in the use of growth factors to enhance wound healing. J. Clin. Invest. 92:2565-2566.
51. Shah, M., D.M. Foreman, and M.W. Ferguson. 1994. Neutralizing antibody to TGF-beta 1,2 reduces cutaneous scarring in adult rodents. J. Cell Sci. 107:1137-1157.
52. Rafferty, N.S. 1973. Experimental cataract and wound healing in the mouse lens. Investig. Ophthalmol. 12:156-160.
53. Uga, S. 1981. Wound healing in the mouse lens. Exp. Eye Res. 322: 175-186.