Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways

Molecular Pharmacology

Volumn 61, Issue 6, 2002, Pages 1313-1321

  Cartee, L ^a   Smith, R ^a   Dai, Y ^a   Rahmani, M ^a   Rosato, R ^a   Almenara, J ^a   Dent, P ^a   Grant, S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISINDOLYLMALEIMIDE; CASPASE 3; CASPASE 8; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOHEXIMIDE; CYTOCHROME C; FLAVOPIRIDOL; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN BID; PROTEIN KINASE C INHIBITOR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRION; MYELOID LEUKEMIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARABIDOPSIS PROTEINS; CARCINOGENS; CASPASE 8; CASPASE 9; CASPASES; DRUG SYNERGISM; ENZYME PRECURSORS; FATTY ACID DESATURASES; FLAVONOIDS; HUMANS; LEUKEMIA, MYELOID; MITOCHONDRIA; PIPERIDINES; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; U937 CELLS;

EID: 0036259143     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.6.1313     Document Type: Article

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