Hepcidin: Iron-hormone and anti-microbial peptide

Gene

Volumn 364, Issue 1-2, 2005, Pages 37-44

  Verga Falzacappa, Maria Vittoria ^a   Muckenthaler, Martina U ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Anaemia of chronic diseases; Anti microbial peptide; Hepcidin; Hereditary hemochromatosis; Iron metabolism

Indexed keywords

ANTIINFECTIVE AGENT; HEPCIDIN; IRON; PEPTIDE;

CONFERENCE PAPER; DEREGULATION; GENE EXPRESSION; HEMOCHROMATOSIS; HOMEOSTASIS; HUMAN; INFECTION; INFLAMMATION; IRON ABSORPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STIMULUS;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; HEMOCHROMATOSIS; HOMEOSTASIS; HUMANS; IRON; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; THALASSEMIA;

EID: 28844472646     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2005.07.020     Document Type: Conference Paper

References (46)

1. K.R. Bridle Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis Lancet 361 2003 669 673
2. C. Camaschella Juvenile and adult hemochromatosis are distinct genetic disorders Eur. J. Hum. Genet. 5 1997 371 375
3. B. Courselaud C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism J. Biol. Chem. 277 2002 41163 41170
4. D.M. Frazer, and G.J. Anderson The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Mol. Diseases 30 2003 288 297
5. D.M. Frazer Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats Gastroenterology 123 2002 835 844
6. D.M. Frazer, S.J. Wilkins, K.N. Millard, A.T. McKie, C.D. Vulpe, and G.J. Anderson Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE Br. J. Haematol. 126 2004 434 436
7. D.M. Frazer Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis Gut 53 2004 1509 1515
8. T. Ganz Is TfR2 the iron sensor? Blood 104 2004 3839 3840
9. M.W. Hentze, M.U. Muckenthaler, and N.C. Andrews Balancing acts: molecular control of mammalian iron metabolism Cell 117 2004 285 297
10. H.N. Hunter, D.B. Fulton, T. Ganz, and H.J. Vogel The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis J. Biol. Chem. 277 2002 37597 37603
11. G. Ilyin Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload FEBS Lett. 542 2003 22 26
12. M.B. Johnson, and C.A. Enns Diferric transferrin regulates transferrin receptor 2 protein stability Blood 104 2004 4287 4293
13. H. Kawabata Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis Blood 105 2005 376 381
14. M.D. Knutson Iron releases from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin Proc. Natl. Acad. Sci. U. S. A. 102 2005 1324 1328
15. A. Krause LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity FEBS Lett. 480 2000 147 150
16. J. Krijt, M. Vokurka, K.T. Chang, and E. Necas Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin Blood 104 2004 4308 4310
17. J. Krijt, R. Cmejla, V. Sykora, M. Vokurka, D. Vyoral, and E. Necas Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice J. Hepatol. 40 2004 891 896
18. H. Kulaksiz Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia Gut 53 2004 735 743
19. A.H. Laftah Effect of hepcidin on intestinal iron absorption in mice Blood 103 2004 3940 3944
20. P. Lee, H. Peng, T. Gelbart, and E. Beutler The IL-6-and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes Proc. Natl. Acad. Sci. U. S. A. 101 2004 9263 9265
21. D.Q. Lou Functional differences between hepcidin 1 and 2 in transgenic mice Blood 103 2004 2816 2821
22. D.Q. Lou Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo Hepatology 41 2005 1056 1064
23. S. Ludwiczek, E. Aigner, I. Theurl, and G. Weiss Cytokine-mediated regulation of iron transport in human monocytic cells Blood 101 2003 4148 4154
24. A.T. Merryweather-Clarke Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis Hum. Mol. Genet. 12 2003 2241 2247
25. G. Montosi Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload Hepatology 41 2005 545 552
26. M. Muckenthaler Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis Nat. Genet. 34 2003 102 107
27. E. Nemeth, E.V. Valore, M. Territo, G. Schiller, A. Lichtenstein, and T. Ganz Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein Blood 101 2003 2461 2463
28. E. Nemeth Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 2004 2090 2093
29. E. Nemeth IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin J. Clin. Invest. 113 2004 1271 1276
30. E. Nemeth, A. Roetto, G. Garozzo, T. Ganz, and C. Camaschella Hepcidin is decreased in TFR2-Hemochromatosis Blood 105 2004 1803 1806
31. G. Nicolas Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice Proc. Natl. Acad. Sci. U. S. A. 98 2001 8780 8785
32. G. Nicolas The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation J. Clin. Invest 110 2002 1037 1044
33. G. Nicolas Severe iron deficiency anemia in transgenic mice expressing liver hepcidin Proc. Natl. Acad. Sci. U. S. A. 99 2002 4596 4601
34. G. Nicolas Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis Nat. Genet. 34 2003 97 101
35. G. Nicolas, N.C. Andrews, A. Kahn, and S. Vaulont Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice Blood 103 2004 2841 2843
36. G. Papanikolaou Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis Nat. Genet. 36 2004 77 82
37. C.H. Park, E.V. Valore, A.J. Waring, and T. Ganz Hepcidin, a urinary antimicrobial peptide synthesized in the liver J. Biol. Chem. 276 2001 7806 7810
38. A. Pietrangelo Non-HFE hemochromatosis Hepatology 39 2004 21 29
39. C. Pigeon A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload J. Biol. Chem. 276 2001 7811 7819
40. S. Rivera, L. Liu, E. Nemeth, V. Gabayan, O.E. Sorensen, and T. Ganz Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia Blood 105 2005 1797 1802
41. A. Robb, and M. Wessling-Resnick Regulation of transferrin receptor 2 protein levels by transferrin Blood 104 2004 4294 4299
42. C.N. Roy An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice Nat. Genet. 36 2004 481 485
43. L.M. Schimanski In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations Blood 105 2005 4096 4102
44. A. Townsend, and H. Drakesmith Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload Lancet 359 2002 786 790
45. L. Viatte Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice Blood 105 2005 4861 4864
46. D.A. Weinstein, C.N. Roy, M.D. Fleming, M.F. Loda, J.I. Wolfsdorf, and N.C. Andrews Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease Blood 100 2002 3776 3781