Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice

Journal of Hepatology

Volumn 40, Issue 6, 2004, Pages 891-896

  Krijt, Jan ^a   Čmejla, Radek ^b   Sýkora, Viktor ^a   Vokurka, Martin ^a   Vyoral, Daniel ^a,b   Nečas, Emanuel ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION   (Czech Republic)

Author keywords

Ferroportin; Hepcidin; Real time PCR; Transferrin receptor 2

Indexed keywords

AMINO ACID; ASPARAGINE; FERROPORTIN 1; HEPCIDIN; IRON; LIPOPOLYSACCHARIDE; LYSINE; MESSENGER RNA; PEPTIDE; PHENYLALANINE; SERINE; TRANSFERRIN RECEPTOR;

AMPLICON; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; IRON OVERLOAD; LIVER; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS; PREDICTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION; IRON; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; PANCREAS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX CHARACTERISTICS; SPECIES SPECIFICITY;

EID: 2442681406     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(04)00125-4     Document Type: Article

References (34)

1. Vacha J., Dungel J., Hola J., Znojil V. The distribution of the haeme and non-haeme fractions of iron in individual regions of the erythropoietic system of intact and acutely irradiated mice. Exp Hematol. 11:1983;714-720
2. Smith A.G., Francis J. Genetic variation of iron-induced porphyria in mice. Biochem J. 291:1993;21-35
3. Fleming R.E., Holden C.C., Tomatsu S., Waheed A., Brunt E.M., Britton R.S., et al. Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis. Proc Natl Acad Sci USA. 98:2001;2707-2711
4. Clothier B., Robinson S., Akhtar R.A., Francis J.E., Peters T.J., Raja K., et al. Genetic variation of basal iron status, ferritin and iron regulatory protein in mice: potential for modulation of oxidative stress. Biochem Pharmacol. 59:2000;115-122
5. Morse A.C., Beard J.L., Jones B.C. A genetic developmental model of iron deficiency: biological aspects. Proc Soc Exp Biol Med. 220:1999;147-152
6. Leboeuf R.C., Tolson D., Heinecke J.W. Dissociation between tissue iron concentrations and transferrin saturation among inbred mouse strains. J Lab Clin Med. 126:1995;128-136
7. Dupic F., Fruchon S., Bensaid M., Loréal O., Brissot P., Borot N., et al. Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice. Gut. 51:2002;648-653
8. Dupic F., Fruchon S., Bensaid M., Borot N., Radosavljevic M., Loreal O., et al. Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains. Gastroenterology. 122:2002;745-751
9. Fleming R.E., Sly W.S. Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease. Proc Natl Acad Sci USA. 98:2001;8160-8162
10. Yang F., Liu X.B., Quinones M., Melby P.C., Ghio A., Haile D.J. Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem. 277:2002;39786-39791
11. Kawabata H., Yang R., Hirama T., Vuong P.T., Kawano S., Gombart A.F. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem. 274:1999;20826-20832
12. Fleming R.E., Migas M.C., Holden C.C., Waheed A., Britton R.S., Tomatsu S., et al. Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci USA. 97:2000;2214-2219
13. Camaschella C., Roetto A., Cali A., DeGobbi M., Garozzo G., Carella M., et al. The gene TRFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet. 25:2000;14-15
14. Montosi G., Donovan A., Totaro A., Garuti C., Pignatti E., Cassanelli S., et al. Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. J Clin Invest. 108:2001;619-623
15. Nicolas G., Bennoun M., Devaux I., Beaumont C., Grandchamp B., Kahn A., et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA. 98:2001;8780-8785
16. Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 276:2001;7811-7819
17. Nicolas G., Chauvet C., Viatte L., Danan J.L., Bigard X., Devaux I., et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 110:2002;1037-1044
18. Weinstein D.A., Roy C.N., Fleming M.D., Loda M.F., Wolfsdorf J.I., Andrews N.C. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood. 100:2002;3776-3781
19. Bridle K.R., Frazer D.M., Wilkins S.J., Dixon J.L., Purdie D.M., Crawford D.H., et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet. 361:2003;669-673
20. Gehrke S.G., Kulaksiz H., Herrmann T., Riedel H.D., Bents K., Veltkamp C., et al. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to serum transferrin saturation and non-transferrin-bound iron. Blood. 102:2003;371-376
21. Ilyin G., Courselaud B., Troadec M.-B., Pigeon C., Alizadeh M., Leroyer P., et al. Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload. Fed Eur Biochem Soc Lett. 542:2003;22-26
22. Nicolas G., Bennoun M., Porteu A., Mativet S., Beaumont C., Grandchamp B., et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA. 99:2002;4596-4601
23. Lou D.-Q., Nicolas G., Lesbordes J.-C., Viatte L., Grimber G., Szajnert M.F., et al. Functional differences between hepcidin-1 and -2 in transgenic mice. Blood. 103:2004;2816-2821
24. Torrance J.D., Bothwell T.H. Tissue iron stores. Methods Hematol. 1:1980;90-115
25. Yeh K.-Y., Yeh M., Glass J. Hepcidin regulation of ferroportin1 expression in the liver and intestine of the rat. Am J Physiol Gastrointest Liver Physiol. 286:2004;G385-G394
26. Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 101:2003;2461-2463
27. Krause A., Neitz S., Magert H.J., Schulz A., Forssmann W.G., Schulz-Knappe P., et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. Fed Eur Biochem Soc Lett. 480:2000;147-150
28. Roetto A., Papanikolaou G., Politou M., Alberti F., Girelli D., Christakis J., et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet. 33:2003;21-22
29. Roetto A., Daraio F., Porporato P., Caruso R., Cox T.M., Cazzola M., et al. Screening hepcidin for mutations in juvenile hemochromatosis: Identification of a new mutation (C70R). Blood. 103:2004;2407-2409
30. Biasiotto G., Belloli S., Ruggeri G., Zanella I., Gerardi G., Corrado M., et al. Identification of new mutations in the HFE, hepcidin and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload. Clin Chem. 49:2003;1981-1988
31. Merryweather-Clarke A.T., Cadet E., Bomford A., Capron D., Viprakasit V., Miller A., et al. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. Hum Mol Genet. 12:2003;2241-2247
32. Jacolot S., Le Gac L., Scotet V., Quere L., Mura C., Ferec C. HAMP as a modifier gene that increase the phenotypic expression of the HFE p.C282Y homozygous genotype. Blood. 103:2004;2835-2840
33. Park C.H., Valore E.V., Waring A.J., Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 276:2001;7806-7810
34. Hunter H.N., Fulton D.B., Ganz T., Vogel H.J. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem. 277:2002;37597-37603