Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload

Lancet

Volumn 359, Issue 9308, 2002, Pages 786-790

  Townsend, Alain ^a   Drakesmith, Hal ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HFE PROTEIN; IRON; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANEMIA; CELL ACTIVITY; CHRONIC INFLAMMATION; CONGENITAL DISORDER; CRYPT CELL; FAMILIAL DISEASE; GENE MUTATION; HEMOCHROMATOSIS; HUMAN; HYPOTHESIS; INTESTINE; IRON ABSORPTION; IRON METABOLISM; IRON OVERLOAD; MOLECULAR MODEL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MODIFICATION; RETICULOENDOTHELIAL SYSTEM; REVIEW; TRANSFERRIN BLOOD LEVEL;

EID: 0037006654     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(02)07885-6     Document Type: Note

References (31)

1. Disorders of iron metabolism
2. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1
3. Iron absorption in relation to transferrin saturation and other factors
4. Importance of anemia and transferrin levels in the regulation of intestinal iron absorption in hypotransferrinemic mice
5. Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
6. Histogenisis of the hepatic lesion in primary hemochromatosis: With consideration of the pseudo-iron deficient state produced by phlebotomies
7. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
8. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor
9. 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man
10. 2-microglobulin interaction and cell surface expression
11. The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor
12. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis
13. Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation
14. Hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells
15. Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
16. Kupffer cell staining by an HFE-specific monoclonal antibody: Implications for hereditary haemochromatosis
17. HFE gene knockout produces mouse model of hereditary hemochromatosis
18. Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis
19. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
20. Iron release from human monocytes after erythrophagocytosis in vitro: An investigation in normal subjects and hereditary hemochromatosis patients
21. Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis
22. The haemochromatosis protein HFE blocks cellular iron export
23. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
24. Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis
25. Genes that modify the hemochromatosis phenotype in mice
26. Transferrin receptor is necessary for development of erythrocytes and the nervous system
27. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
28. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
29. A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis
30. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice