Effect of hepcidin on intestinal iron absorption in mice

Blood

Volumn 103, Issue 10, 2004, Pages 3940-3944

  Laftah, Abas H ^b   Ramesh, Bala ^b   Simpson, Robert J ^b   Solanky, Nita ^b   Bahram, Seiamak ^b   Schümann, Klaus ^b   Debnam, Edward S ^b   Srai, Surjit K S ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; IRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IRON ABSORPTION; IRON DEFICIENCY; KNOCKOUT MOUSE; LIVER METABOLISM; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMALL INTESTINE ABSORPTION;

EID: 2042491616     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-03-0953     Document Type: Article

References (20)

1. Fleming RE, Sly WS. Mechanisms of iron accumulation in hereditary hemochromatosis. Annu Rev Physiol. 2002;64:663-680.
2. Pletrangelo A. Physiology of iron transport and the hemochromatosis gene. Am J Physiol. 2002;282:403-414.
3. Nicolas G, Bennoun M, Devaux I, at al. Lack of hepcidin gene expression and severe tissue iron overload in upstream factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A. 2001;98:8780-8785.
4. Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276:7811-7819.
5. Finch C. Regulators of iron balance in humans. Blood. 1994;84:1697-1702.
6. Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110:1037-1044.
7. Roetto A, Papanikolaou G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet. 2003;33:21-22.
8. Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002;99:4596-4601.
9. Frazer DM, Wilkins SJ, Becker EM, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 2002;123:835-844.
10. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101:2461-2463.
11. Bahram S, Gilfillan S, Kuhn LC, et al. Experimental hemochromatosis due to MHC class I HFE deficiency, immune status and iron metabolism. Proc Natl Acad Sci USA. 1999;96:13312-13317.
12. Harwig SS, Ganz T, Lehrer RI. Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol. 1994;236:160-172.
13. Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276:7806-7810.
14. 3+ uptake in vitro and in vivo by mouse duodenum. Biochim Biophys Acta. 1987;901:52-60.
15. Simpson RJ, Lombard M, Raja KR, Thatcher R, Peters TJ. Iron absorption by hypotransferrinaemic mice. Br J Haematol. 1991;78:565-570.
16. Conrad ME. Humoral regulation of iron absorption. Gastroenterology. 1969;57:225-228.
17. 59Fe movement across the intestinal wall in duodenal ret segments ex vivo. Am J Physiol. 1999;276:G431-G444.
18. Simpson RJ. Dietary iron levels and hypoxia independently affect iron absorption in mice. J Nutr. 1998;126:1858-1864.
19. Ahmad KA, Ahmann JR, Migas MC, et al. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells Mol Dis. 2002;29:361-366.
20. Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet. 2003;361:669-673.