Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils

Journal of Clinical Investigation

Volumn 115, Issue 11, 2005, Pages 3117-3127

  Genestier, Anne Laure ^a   Michallet, Marie Cécile ^b   Prévost, Gilles ^c   Bellot, Gregory ^d   Chalabreysse, Lara ^e   Peyrol, Simone ^f   Thivolet, Françoise ^e   Etienne, Jerome ^a   Lina, Gérard ^a   Vallette, François M ^d   Vandenesch, François ^a   Genestier, Laurent ^a,b  

^a INSERM   (France)

^b University Lyon i   (France)

^c UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^d UNIVERSITÉ DE NANTES   (France)

^e LOUIS PRADEL HOSPITAL   (France)

^f Centre Commun d'Imagerie Laennec (CeCIL)   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; LEUKOCIDIN; PANTON VALENTINE LEUKOCIDIN; PROTEIN BCL 2; PROTEIN LUKS PV; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; STAPHYLOCOCCUS ENTEROTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; HUMAN; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; NECROTIZING PNEUMONIA; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PNEUMONIA; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN TARGETING; STAPHYLOCOCCUS AUREUS;

EID: 27644538026     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI22684     Document Type: Article

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