Neuroprotection by a caspase inhibitor in acute bacterial meningitis

Nature Medicine

Volumn 5, Issue 3, 1999, Pages 298-302

  Braun, J S ^a   Novak, R ^a   Herzog, K H ^a   Bodner, S M ^a   Cleveland, J L ^a,b   Tuomanen, E I ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE INHIBITOR; KETONE DERIVATIVE; N BENZYLOXYLCARBONYLVALYLALANYLASPARTYLFLUOROMETHYLKETONE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL MENINGITIS; BRAIN PROTECTION; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; HUMAN; HUMAN CELL; INTRACISTERNAL DRUG ADMINISTRATION; LEUKOCYTE MIGRATION; MALE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RABBIT;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTIGENS, CD18; APOPTOSIS; CASPASES; CELL LINE; CYSTEINE PROTEINASE INHIBITORS; HIPPOCAMPUS; HUMANS; MALE; MENINGITIS, BACTERIAL; NEURONS; NEUROPROTECTIVE AGENTS; PNEUMOCOCCAL INFECTIONS; RABBITS;

ANIMALIA; BACTERIA (MICROORGANISMS); ORYCTOLAGUS CUNICULUS;

EID: 0032977353     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/6514     Document Type: Article

References (31)

1. Schuchat, A. et al. Bacterial meningitis in the United States in 1995. N. Engl. J. Med. 337, 970-976 (1997).
2. Quagliarello, V. & Scheld, W.M. Bacterial meningitis: pathogenesis, pathophysiology, and progress. N. Engl. J. Med. 327, 864-872 (1992).
3. Saez-Llorens, X., Ramilo, O., Mustafa, M.M., Mertsola, J. & McCracken Jr., G.H. Molecular pathophysiology of bacterial meningitis Current concepts and therapeutic implications. J. Pediatr. 116, 671-684 (1990).
4. Tuomanen, E.I., Saukkonen, K., Sande, S., Cioffe, C. & Wright, S.D. Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes. J. Exp. Med. 170, 959-969 (1989).
5. Saukkonen, K. et al. The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis. J. Exp. Med. 171, 439-448 (1990).
6. Zysk, G. et al. Anti-inflammatory treatment influences neuronal apoptotic cell death in the dentate gyrus in experimental pneumococcal meningitis. J. Neuropathol. Exp. Neurol. 55, 722-728 (1996).
7. Leib, S.L., Kim, Y.S., Chow, L.L., Sheldon, R.A. & Tauber, M.G. Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J. Clin. Invest. 98, 2632-2639 (1996).
8. Linnik, M.D., Zobrist, R.H. & Hatfield, M.D. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24, 2002-2009 (1993).
9. Tauber, M.G., Kim, Y.S. & Leib, S.L. in in In Defense of the Brain: Current Concepts in the Immunopathogenesis and Clinical Aspects of CNS Infections (eds. Peterson, P.K. & Remington, J.S.) 125-143 (Blackwell Science, Malden, Massachusetts, 1997).
10. Cohen, G.M. Caspases: the executioners of apoptosis. Biochem. J. 326, 1-16 (1997).
11. Milligan, C.E. et al. Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro. Neuron 15, 385-393 (1995).
12. Braun, J.S. & Tuomanen, E.I. Molecular mechanisms of brain damage in bacterial meningitis. Adv. Pediatr. Infect. Dis. 14, 49-72 (1998).
13. Tauber, M.G. & Zwahlen, A. Animal models for meningitis. Methods Enzymol. 235, 93-106 (1994).
14. Dodel, R.C. et al. Peptide inhibitors of caspase-3-like proteases attenuate 1 -methyl-4-phenylpyridinum-induced toxicity of cultured fetal rat mesencephalic dopamine neurons. Neuroscience 86, 701-707 (1998).
15. Pronk, G.J., Ramer, K., Amiri, P. & Williams, L.T. Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER. Science 271, 808-810 (1996).
16. Slee, E.A. et al. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem. J. 315, 21-24 (1996).
17. Chen, Y. & Zychlinsky, A. Apoptosis induced by bacterial pathogens. Microb. Pothog. 17, 203-212 (1994).
18. Zychlinsky, A., Prevost, M.C. & Sansonetti, P.J. Shigella flexneri induces apoptosis in infected macrophages. Nature 358, 167-169 (1992).
19. Zychlinsky, A. & Sansonetti, P. Apoptosis in bacterial pathogenesis. J. Clin. Invest. 100, 493-496 (1997).
20. Tauber, M.G., Sachdeva, M., Kennedy, S.L., Loetscher, H. & Lesslauer, W. Toxicity in neuronal cells caused by cerebrospinal fluid from pneumococcal and gram-negative meningitis. J. Infect. Dis. 166, 1045-1050 (1992).
21. Hara, H. et al. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and exitotoxic neuronal damage. Proc. Natl. Acad. Sci. USA 94, 2007-2012 (1997).
22. Auer, R.N. & Siesjo, B.K. Biological differences between ischemia, hypoglycemia, and epilepsy. Ann. Neural. 24, 699-707 (1988).
23. Leib, S.L., Kim, Y.S., Ferriero, D.M. & Tauber, M.G. Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis. J. Infect. Dis. 173, 166-171 (1996).
24. Roos, K.L., Tunkel, A.R. & Scheid, W.M. in Infections of the Central Nervous System. (eds. Scheld, W.M., Whitley, R.J. & Durack, D.T.) 335-401 (Lippincott-Raven, Philadelphia, 1997).
25. Ankarcrona, M. et al. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15, 961-973 (1995).
26. Eichhold, T., Hookfin, E., Taiwo, Y., De, B. & Wehmeyer, K. Isolation and quantification of fluoroacetate in rat tissues, following dosing of Z-Phe-Ala-CH2-F, a peptidyl fluoromethyl ketone protease inhibitor. J. Pharm. Biomed. Anal. 16, 459-467 (1997).
27. Ronnett, G.V., Hester, L.D., Nye, J.S. & Snyder, S.H. Human cerebral cortical cell lines from patients with unilateral megalencephaly and Rasmussen's encephalitis. Neuroscience 63, 1081-1099 (1994).
28. Lacks, S.A. & Hotchkiss, R.D. A study of the genetic material determining an enzyme activity in pneumococcus. Biochim. Biophys. Acta 39, 508-517 (1960).
29. Pitrak, D.L., Tsai, H.C., Mullane, K.M., Sutton, S.H. & Stevens, P. Accelerated neutrophil apoptosis in the acquired immunodeficiency syndrome. J. Clin. Invest. 98, 2714-2719 (1996).
30. Gavrieli, Y., Sherman, Y. & Ben-Sasson, S.A. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501 (1992).
31. Evers, P., Uylings, H.B.M. & Suurmeijer, A.J.H. Antigen retrieval in formaldehyde-fixed human brain tissue. Methods 15, 133-140 (1998).