-
1
-
-
0037329747
-
Cellular functions of the Rap1 GTP-binding protein: A pattern emerges
-
Caron E. Cellular functions of the Rap1 GTP-binding protein: a pattern emerges. J Cell Sci. 2003;116:435-440.
-
(2003)
J Cell Sci
, vol.116
, pp. 435-440
-
-
Caron, E.1
-
2
-
-
5444267347
-
Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking
-
Katagiri K, Ohnishi N, Kabashima K, et al. Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol. 2004;5:1045-1051.
-
(2004)
Nat Immunol
, vol.5
, pp. 1045-1051
-
-
Katagiri, K.1
Ohnishi, N.2
Kabashima, K.3
-
3
-
-
0036789949
-
Ras and relatives: Job sharing and networking keep an old family together
-
Ehrhardt A, Ehrhardt G, Guo X, Schrader J. Ras and relatives: job sharing and networking keep an old family together. Exp Hematol. 2002;30:1089-1106.
-
(2002)
Exp Hematol
, vol.30
, pp. 1089-1106
-
-
Ehrhardt, A.1
Ehrhardt, G.2
Guo, X.3
Schrader, J.4
-
4
-
-
0842266583
-
Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion
-
Bivona TG, Wiener HH, Ahearn IM, Silletti J, Chiu VK, Philips MR. Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol. 2004;164:461-470.
-
(2004)
J Cell Biol
, vol.164
, pp. 461-470
-
-
Bivona, T.G.1
Wiener, H.H.2
Ahearn, I.M.3
Silletti, J.4
Chiu, V.K.5
Philips, M.R.6
-
5
-
-
4344691642
-
Membranes as messengers in T cell adhesion signaling
-
Dustin ML, Bivona TG, Philips MR. Membranes as messengers in T cell adhesion signaling. Nat Immunol. 2004;5:363-372.
-
(2004)
Nat Immunol
, vol.5
, pp. 363-372
-
-
Dustin, M.L.1
Bivona, T.G.2
Philips, M.R.3
-
6
-
-
4644359853
-
Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human mega-karyocytes
-
Balduini A, Pecci A, Lova P, et al. Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human mega-karyocytes. Exp Cell Res. 2004;300:84-93.
-
(2004)
Exp Cell Res
, vol.300
, pp. 84-93
-
-
Balduini, A.1
Pecci, A.2
Lova, P.3
-
7
-
-
0038741814
-
Does Rap1 deserve a bad Rap?
-
Stork PJS. Does Rap1 deserve a bad Rap? Trends Biochem Sci. 2003;28:267-275.
-
(2003)
Trends Biochem Sci
, vol.28
, pp. 267-275
-
-
Stork, P.J.S.1
-
8
-
-
0028881018
-
Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G
-
Gotoh T, Hattori S, Nakamura S, et al. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol Cell Biol. 1995;15:6746-6753.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 6746-6753
-
-
Gotoh, T.1
Hattori, S.2
Nakamura, S.3
-
9
-
-
0034634534
-
Identification of guanine nucleotide exchange factors for the Rap1 GTPase: Regulation of MR-GEF by M-Ras-GTP interaction
-
Rebhun JF, Castro AF, Quilliam LA. Identification of guanine nucleotide exchange factors for the Rap1 GTPase: regulation of MR-GEF by M-Ras-GTP interaction. J Biol Chem. 2000;275:34901-34908.
-
(2000)
J Biol Chem
, vol.275
, pp. 34901-34908
-
-
Rebhun, J.F.1
Castro, A.F.2
Quilliam, L.A.3
-
10
-
-
0033621326
-
PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2
-
de Rooij J, Boenink NM, van Triest M, Cool RH, Wittinghofer A, Bos JL. PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2. J Biol Chem. 1999;274:38125-38130.
-
(1999)
J Biol Chem
, vol.274
, pp. 38125-38130
-
-
De Rooij, J.1
Boenink, N.M.2
Van Triest, M.3
Cool, R.H.4
Wittinghofer, A.5
Bos, J.L.6
-
11
-
-
0032480888
-
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
-
de Rooij J, Zwartkruis FJ, Verheijen MH, et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature. 1998;396:474-477.
-
(1998)
Nature
, vol.396
, pp. 474-477
-
-
De Rooij, J.1
Zwartkruis, F.J.2
Verheijen, M.H.3
-
12
-
-
0032545328
-
A family of cAMP-binding proteins that directly activate Rap1
-
Kawasaki H, Springett GM, Mochizuki N, et al. A family of cAMP-binding proteins that directly activate Rap1. Science. 1998;282:2275-2279.
-
(1998)
Science
, vol.282
, pp. 2275-2279
-
-
Kawasaki, H.1
Springett, G.M.2
Mochizuki, N.3
-
13
-
-
0037441566
-
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2
-
Kuiperij HB, de Rooij J, Rehmann H, et al. Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. Biochim Biophys Acta. 2003;1593:141-149.
-
(2003)
Biochim Biophys Acta
, vol.1593
, pp. 141-149
-
-
Kuiperij, H.B.1
De Rooij, J.2
Rehmann, H.3
-
14
-
-
13144282666
-
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
-
U S A
-
Kawasaki H, Springett GM, Toki S, et al. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci U S A. 1998;95:13278-13283.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 13278-13283
-
-
Kawasaki, H.1
Springett, G.M.2
Toki, S.3
-
15
-
-
0034644772
-
Characterization of RasGRP2, a plasma membranetargeted, dual specificity Ras/Rap exchange factor
-
Clyde-Smith J, Silins G, Gartside M, et al. Characterization of RasGRP2, a plasma membranetargeted, dual specificity Ras/Rap exchange factor. J Biol Chem. 2000;275:32260-32267.
-
(2000)
J Biol Chem
, vol.275
, pp. 32260-32267
-
-
Clyde-Smith, J.1
Silins, G.2
Gartside, M.3
-
16
-
-
0034682779
-
CalDAG-GEFIII activation of Ras, R-Ras, and Rap1
-
Yamashita S, Mochizuki N, Ohba Y, et al. CalDAG-GEFIII activation of Ras, R-Ras, and Rap1. J Biol Chem. 2000;275:25488-25493.
-
(2000)
J Biol Chem
, vol.275
, pp. 25488-25493
-
-
Yamashita, S.1
Mochizuki, N.2
Ohba, Y.3
-
17
-
-
0037423929
-
DOCK4, a GTPase activator, is disrupted during tumorigenesis
-
Yajnik V, Paulding C, Sordella R, et al. DOCK4, a GTPase activator, is disrupted during tumorigenesis. Cell. 2003;112:673-684.
-
(2003)
Cell
, vol.112
, pp. 673-684
-
-
Yajnik, V.1
Paulding, C.2
Sordella, R.3
-
18
-
-
0034730244
-
p130Cas regulates the activity of AND-34, a novel ral, rap1, and R-Ras guanine nucleotide exchange factor
-
Gotoh T, Cai D, Tian X, Feig LA, Lerner A. p130Cas regulates the activity of AND-34, a novel ral, rap1, and R-Ras guanine nucleotide exchange factor. J Biol Chem. 2000;275:30118-30123.
-
(2000)
J Biol Chem
, vol.275
, pp. 30118-30123
-
-
Gotoh, T.1
Cai, D.2
Tian, X.3
Feig, L.A.4
Lerner, A.5
-
19
-
-
0035839496
-
Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling
-
Jin TG, Satoh T, Liao Y, et al. Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. J Biol Chem. 2001;276:30301-30307.
-
(2001)
J Biol Chem
, vol.276
, pp. 30301-30307
-
-
Jin, T.G.1
Satoh, T.2
Liao, Y.3
-
20
-
-
0035971241
-
Rap1 Is activated by erythropoietin or interleukin-3 and is involved in regulation of beta 1 integrin-mediated hematopoietic cell adhesion
-
Arai A, Nosaka Y, Kanda E, Yamamoto K, Miyasaka N, Miura O. Rap1 Is activated by erythropoietin or interleukin-3 and is involved in regulation of beta 1 integrin-mediated hematopoietic cell adhesion. J Biol Chem. 2001;276:10453-10462.
-
(2001)
J Biol Chem
, vol.276
, pp. 10453-10462
-
-
Arai, A.1
Nosaka, Y.2
Kanda, E.3
Yamamoto, K.4
Miyasaka, N.5
Miura, O.6
-
21
-
-
0035475308
-
Crk family adaptors - Signalling complex formation and biological roles
-
Feller SM. Crk family adaptors - signalling complex formation and biological roles. Oncogene. 2001;20:6348-6371.
-
(2001)
Oncogene
, vol.20
, pp. 6348-6371
-
-
Feller, S.M.1
-
22
-
-
0030771490
-
Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL, and Grb2
-
Ichiba T, Kuraishi Y, Sakai O, et al. Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL, and Grb2. J Biol Chem. 1997;272:22215-22220.
-
(1997)
J Biol Chem
, vol.272
, pp. 22215-22220
-
-
Ichiba, T.1
Kuraishi, Y.2
Sakai, O.3
-
23
-
-
0034652014
-
IFN-gamma activates the C3G/Rap1 signaling pathway
-
Alsayed Y, Uddin S, Ahmad S, et al. IFN-gamma activates the C3G/Rap1 signaling pathway. J Immunol. 2000;164:1800-1806.
-
(2000)
J Immunol
, vol.164
, pp. 1800-1806
-
-
Alsayed, Y.1
Uddin, S.2
Ahmad, S.3
-
24
-
-
0030812812
-
Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1
-
Boussiotis VA, Freeman GJ, Berezovskaya A, Barber DL, Nadler LM. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science. 1997;278:124-128.
-
(1997)
Science
, vol.278
, pp. 124-128
-
-
Boussiotis, V.A.1
Freeman, G.J.2
Berezovskaya, A.3
Barber, D.L.4
Nadler, L.M.5
-
25
-
-
0142211303
-
Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation
-
Christian SL, Lee RL, McLeod SJ, et al. Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation. J Biol Chem. 2003;278:41756-41767.
-
(2003)
J Biol Chem
, vol.278
, pp. 41756-41767
-
-
Christian, S.L.1
Lee, R.L.2
McLeod, S.J.3
-
26
-
-
0030969634
-
Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins
-
Barber DL, Mason JM, Fukazawa T, et al. Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins. Blood. 1997;89:3166-3174.
-
(1997)
Blood
, vol.89
, pp. 3166-3174
-
-
Barber, D.L.1
Mason, J.M.2
Fukazawa, T.3
-
27
-
-
0032475982
-
Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G
-
Kirsch KH, Georgescu MM, Hanafusa H. Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G. J Biol Chem. 1998;273:25673-25679.
-
(1998)
J Biol Chem
, vol.273
, pp. 25673-25679
-
-
Kirsch, K.H.1
Georgescu, M.M.2
Hanafusa, H.3
-
28
-
-
0034646610
-
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL
-
Sakkab D, Lewitzky M, Posern G, et al. Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. J Biol Chem. 2000;275:10772-10778.
-
(2000)
J Biol Chem
, vol.275
, pp. 10772-10778
-
-
Sakkab, D.1
Lewitzky, M.2
Posern, G.3
-
29
-
-
19944432451
-
Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions
-
Fukuyama T, Ogita H, Kawakatsu T, et al. Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions. J Biol Chem. 2005;280:815-825.
-
(2005)
J Biol Chem
, vol.280
, pp. 815-825
-
-
Fukuyama, T.1
Ogita, H.2
Kawakatsu, T.3
-
30
-
-
0036161707
-
PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1
-
Schmitt JM, Stork PJS. PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1. Mol Cell. 2002;9:85-94.
-
(2002)
Mol Cell
, vol.9
, pp. 85-94
-
-
Schmitt, J.M.1
Stork, P.J.S.2
-
31
-
-
10544225380
-
Crkl is constitutively tyrosine phosphorylated in platelets from chronic myelogenous leukemia patients and inducibly phosphorylated in normal platelets stimulated by thrombopoietin
-
Oda A, Miyakawa Y, Druker BJ, et al. Crkl is constitutively tyrosine phosphorylated in platelets from chronic myelogenous leukemia patients and inducibly phosphorylated in normal platelets stimulated by thrombopoietin. Blood. 1996;88:4304-4313.
-
(1996)
Blood
, vol.88
, pp. 4304-4313
-
-
Oda, A.1
Miyakawa, Y.2
Druker, B.J.3
-
32
-
-
0036790996
-
Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling
-
U S A
-
Eto K, Murphy R, Kerrigan SW, et al. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc Natl Acad Sci U S A. 2002;99:12819-12824.
-
(2002)
Proc Natl Acad Sci
, vol.99
, pp. 12819-12824
-
-
Eto, K.1
Murphy, R.2
Kerrigan, S.W.3
-
33
-
-
4644221351
-
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
-
Crittenden JR, Bergmeier W, Zhang Y, et al. CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med. 2004;10:982-986.
-
(2004)
Nat Med
, vol.10
, pp. 982-986
-
-
Crittenden, J.R.1
Bergmeier, W.2
Zhang, Y.3
-
34
-
-
0034658333
-
RasGRP links T-cell receptor signaling to Ras
-
Ebinu JO, Stang SL, Teixeira C, et al. RasGRP links T-cell receptor signaling to Ras. Blood. 2000;95:3199-3203.
-
(2000)
Blood
, vol.95
, pp. 3199-3203
-
-
Ebinu, J.O.1
Stang, S.L.2
Teixeira, C.3
-
35
-
-
0042237772
-
Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3
-
Teixeira C, Stang SL, Zheng Y, Beswick NS, Stone JC. Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. Blood. 2003;102:1414-1420.
-
(2003)
Blood
, vol.102
, pp. 1414-1420
-
-
Teixeira, C.1
Stang, S.L.2
Zheng, Y.3
Beswick, N.S.4
Stone, J.C.5
-
36
-
-
0037067713
-
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs: Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function
-
Yang Y, Li L, Wong GW, et al. RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs: identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. J Biol Chem. 2002;277:25756-25774.
-
(2002)
J Biol Chem
, vol.277
, pp. 25756-25774
-
-
Yang, Y.1
Li, L.2
Wong, G.W.3
-
37
-
-
7244242394
-
The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
-
Enserink JM, Price LS, Methi T, et al. The cAMPEpac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin. J Biol Chem. 2004;279:44889-44896.
-
(2004)
J Biol Chem
, vol.279
, pp. 44889-44896
-
-
Enserink, J.M.1
Price, L.S.2
Methi, T.3
-
38
-
-
17044386676
-
Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU
-
Murphy MM, Zayed MA, Evans A, et al. Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU. Blood. 2005;105:3322-3329.
-
(2005)
Blood
, vol.105
, pp. 3322-3329
-
-
Murphy, M.M.1
Zayed, M.A.2
Evans, A.3
-
39
-
-
11144305139
-
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway
-
Fukuhara S, Sakurai A, Sano H, et al. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol. 2005;25:136-146.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 136-146
-
-
Fukuhara, S.1
Sakurai, A.2
Sano, H.3
-
40
-
-
18144401240
-
Inhibitory control of TGF-beta1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes
-
Basoni C, Nobles M, Grimshaw A, et al. Inhibitory control of TGF-beta1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes. FASEB J. 2005;19:822-824.
-
(2005)
FASEB J
, vol.19
, pp. 822-824
-
-
Basoni, C.1
Nobles, M.2
Grimshaw, A.3
-
41
-
-
2442669194
-
The GTPase-activating protein Rap1GAP uses a catalytic asparagine
-
Daumke O, Weyand M, Chakrabarti PP, Vetter IR, Wittinghofer A. The GTPase-activating protein Rap1GAP uses a catalytic asparagine. Nature. 2004;429:197-201.
-
(2004)
Nature
, vol.429
, pp. 197-201
-
-
Daumke, O.1
Weyand, M.2
Chakrabarti, P.P.3
Vetter, I.R.4
Wittinghofer, A.5
-
42
-
-
0025961448
-
Purification of a plasma membrane-assoicated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells
-
U S A
-
Polakis PG, Rubinfeld B, Evans T, McCormick F. Purification of a plasma membrane-assoicated GTPase-activating protein specific for rap1/ Krev-1 from HL60 cells. Proc Natl Acad Sci U S A. 1991;88:239-243.
-
(1991)
Proc Natl Acad Sci
, vol.88
, pp. 239-243
-
-
Polakis, P.G.1
Rubinfeld, B.2
Evans, T.3
McCormick, F.4
-
43
-
-
0028947758
-
Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression
-
Hattori M, Tsukamoto N, Nur-e-Kamal MS, et al. Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Mol Cell Biol. 1995;15:552-560.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 552-560
-
-
Hattori, M.1
Tsukamoto, N.2
Nur-e-Kamal, M.S.3
-
44
-
-
0030780650
-
Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2: Segregate expression profiles from a rap1GAP gene product
-
Kurachi H, Wada Y, Tsukamoto N, et al. Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2: segregate expression profiles from a rap1GAP gene product. J Biol Chem. 1997;272:28081-28088.
-
(1997)
J Biol Chem
, vol.272
, pp. 28081-28088
-
-
Kurachi, H.1
Wada, Y.2
Tsukamoto, N.3
-
45
-
-
10744228326
-
Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice
-
Ishida D, Kometani K, Yang H, et al. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell. 2003;4:55-65.
-
(2003)
Cancer Cell
, vol.4
, pp. 55-65
-
-
Ishida, D.1
Kometani, K.2
Yang, H.3
-
46
-
-
17044406762
-
Rap1GAP2 is a new GTPase activating protein of Rap1 expressed in human platelets
-
Schultess J, Danielewski O, Smolenski AP. Rap1GAP2 is a new GTPase activating protein of Rap1 expressed in human platelets. Blood. 2005;105:3185-3192.
-
(2005)
Blood
, vol.105
, pp. 3185-3192
-
-
Schultess, J.1
Danielewski, O.2
Smolenski, A.P.3
-
47
-
-
15044359236
-
Linking Rap to cell adhesion
-
Bos JL. Linking Rap to cell adhesion. Curr Opin Cell Biol. 2005;17:123-128.
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 123-128
-
-
Bos, J.L.1
-
48
-
-
0032523064
-
Integrin signaling: The platelet paradigm
-
Shattil SJ, Kashiwagi H, Pampori N. Integrin signaling: the platelet paradigm. Blood. 1998;91:2645-2657.
-
(1998)
Blood
, vol.91
, pp. 2645-2657
-
-
Shattil, S.J.1
Kashiwagi, H.2
Pampori, N.3
-
49
-
-
0036009116
-
Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling
-
Sebzda E, Bracke M, Tugal T, Hogg N, Cantrell DA. Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling. Nat Immunol. 2002;3:251-258.
-
(2002)
Nat Immunol
, vol.3
, pp. 251-258
-
-
Sebzda, E.1
Bracke, M.2
Tugal, T.3
Hogg, N.4
Cantrell, D.A.5
-
50
-
-
1842425828
-
The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes
-
McLeod SJ, Shum AJ, Lee RL, Takei F, Gold MR. The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes. J Biol Chem. 2004;279:12009-12019.
-
(2004)
J Biol Chem
, vol.279
, pp. 12009-12019
-
-
McLeod, S.J.1
Shum, A.J.2
Lee, R.L.3
Takei, F.4
Gold, M.R.5
-
51
-
-
0036681723
-
The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): Potential role for Rap2 in promoting B cell migration
-
McLeod SJ, Li AH, Lee RL, Burgess AE, Gold MR. The Rap GTPases regulate B cell migration toward the chemokine stromal cell-derived factor-1 (CXCL12): potential role for Rap2 in promoting B cell migration. J Immunol. 2002;169:1365-1371.
-
(2002)
J Immunol
, vol.169
, pp. 1365-1371
-
-
McLeod, S.J.1
Li, A.H.2
Lee, R.L.3
Burgess, A.E.4
Gold, M.R.5
-
52
-
-
0034689050
-
The small GTPase, Rap1, mediates CD31-induced integrin adhesion
-
Reedquist KA, Ross E, Koop EA, et al. The small GTPase, Rap1, mediates CD31-induced integrin adhesion. J Cell Biol. 2000;148:1151-1158.
-
(2000)
J Cell Biol
, vol.148
, pp. 1151-1158
-
-
Reedquist, K.A.1
Ross, E.2
Koop, E.A.3
-
53
-
-
0037119416
-
The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA- 1-and VLA-4-mediated cell adhesion
-
de Bruyn KM, Rangarajan S, Reedquist KA, Figdor CG, Bos JL. The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA- 1-and VLA-4-mediated cell adhesion. J Biol Chem. 2002;277:29468-29476.
-
(2002)
J Biol Chem
, vol.277
, pp. 29468-29476
-
-
De Bruyn, K.M.1
Rangarajan, S.2
Reedquist, K.A.3
Figdor, C.G.4
Bos, J.L.5
-
54
-
-
0036146452
-
Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses
-
Katagiri K, Hattori M, Minato N, Kinashi T. Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses. Mol Cell Biol. 2002;22:1001-1015.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1001-1015
-
-
Katagiri, K.1
Hattori, M.2
Minato, N.3
Kinashi, T.4
-
55
-
-
0038266207
-
The small GTPase Rap1 is activated by turbulence and is involved in integrin αIIbβ3-mediated cell adhesion in human megakaryocytes
-
de Bruyn KM, Zwartkruis FJ, de Rooij J, Akkerman JW, Bos JL. The small GTPase Rap1 is activated by turbulence and is involved in integrin αIIbβ3-mediated cell adhesion in human megakaryocytes. J Biol Chem. 2003;278:22412-22417.
-
(2003)
J Biol Chem
, vol.278
, pp. 22412-22417
-
-
De Bruyn, K.M.1
Zwartkruis, F.J.2
De Rooij, J.3
Akkerman, J.W.4
Bos, J.L.5
-
56
-
-
0037067748
-
Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton
-
Bertoni A, Tadokoro S, Eto K, et al. Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton. J Biol Chem. 2002;277:25715-25721.
-
(2002)
J Biol Chem
, vol.277
, pp. 25715-25721
-
-
Bertoni, A.1
Tadokoro, S.2
Eto, K.3
-
57
-
-
0034710567
-
The GTPase Rap1 controls functional activation of macrophage integrin αMβ2 and other inflammatory mediators
-
Caron E, Self AJ, Hall A. The GTPase Rap1 controls functional activation of macrophage integrin αMβ2 and other inflammatory mediators. Curr Biol. 2000;10:974-978.
-
(2000)
Curr Biol
, vol.10
, pp. 974-978
-
-
Caron, E.1
Self, A.J.2
Hall, A.3
-
58
-
-
0033621446
-
The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration
-
Uemura N, Griffin JD. The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration. J Biol Chem. 1999;274:37525- 37532.
-
(1999)
J Biol Chem
, vol.274
, pp. 37525-37532
-
-
Uemura, N.1
Griffin, J.D.2
-
59
-
-
0033967470
-
Sequential regulation of the small GTPase Rap1 in human platelets
-
Franke B, van Triest M, de Bruijn KM, et al. Sequential regulation of the small GTPase Rap1 in human platelets. Mol Cell Biol. 2000;20:779-785.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 779-785
-
-
Franke, B.1
Van Triest, M.2
De Bruijn, K.M.3
-
60
-
-
0042490495
-
RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
-
Katagiri K, Maeda A, Shimonaka M, Kinashi T. RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol. 2003;4:741-748.
-
(2003)
Nat Immunol
, vol.4
, pp. 741-748
-
-
Katagiri, K.1
Maeda, A.2
Shimonaka, M.3
Kinashi, T.4
-
61
-
-
0038647351
-
The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration
-
Tohyama Y, Katagiri K, Pardi R, Lu C, Springer TA, Kinashi T. The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration. Mol Biol Cell. 2003;14:2570-2582.
-
(2003)
Mol Biol Cell
, vol.14
, pp. 2570-2582
-
-
Tohyama, Y.1
Katagiri, K.2
Pardi, R.3
Lu, C.4
Springer, T.A.5
Kinashi, T.6
-
62
-
-
14244260906
-
Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes
-
Fujita H, Fukuhara S, Sakurai A, et al. Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes. J Biol Chem. 2005;280:5022-5031.
-
(2005)
J Biol Chem
, vol.280
, pp. 5022-5031
-
-
Fujita, H.1
Fukuhara, S.2
Sakurai, A.3
-
63
-
-
5044241734
-
RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion
-
Lafuente EM, van Puijenbroek AA, Krause M, et al. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell. 2004;7:585-595.
-
(2004)
Dev Cell
, vol.7
, pp. 585-595
-
-
Lafuente, E.M.1
Van Puijenbroek, A.A.2
Krause, M.3
-
64
-
-
0024600222
-
A ras-related gene with transformation suppressor activity
-
Kitayama H, Sugimoto Y, Matsuzaki T, Ikawa Y, Noda M. A ras-related gene with transformation suppressor activity. Cell. 1989;56:77-84.
-
(1989)
Cell
, vol.56
, pp. 77-84
-
-
Kitayama, H.1
Sugimoto, Y.2
Matsuzaki, T.3
Ikawa, Y.4
Noda, M.5
-
65
-
-
0034996666
-
Cyclic AMP-mediated inhibition of cell growth requires the small G protein rap1
-
Schmitt JM, Stork PJS. Cyclic AMP-mediated inhibition of cell growth requires the small G protein rap1. Mol Cell Biol. 2001;21:3671-3683.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3671-3683
-
-
Schmitt, J.M.1
Stork, P.J.S.2
-
66
-
-
0027170176
-
RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts
-
Cook SJ, Rubinfeld B, Albert I, McCormick F. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J. 1993;12:3475-3485.
-
(1993)
EMBO J
, vol.12
, pp. 3475-3485
-
-
Cook, S.J.1
Rubinfeld, B.2
Albert, I.3
McCormick, F.4
-
67
-
-
0033756553
-
CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1
-
Carey KD, Dillon TJ, Schmitt JM, et al. CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1. Mol Cell Biol. 2000;20:8409-8419.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8409-8419
-
-
Carey, K.D.1
Dillon, T.J.2
Schmitt, J.M.3
-
69
-
-
85006314494
-
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
-
Enserink JM, Christensen AE, De Rooij J, et al. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol. 2002;4:901-906.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 901-906
-
-
Enserink, J.M.1
Christensen, A.E.2
De Rooij, J.3
-
70
-
-
0037040883
-
Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
-
McDermott EP, O'Neill LA. Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1. J Biol Chem. 2002;277:7808-7815.
-
(2002)
J Biol Chem
, vol.277
, pp. 7808-7815
-
-
McDermott, E.P.1
O'Neill, L.A.2
-
71
-
-
3142688998
-
Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes
-
Remans PH, Gringhuis SI, Van Laar JM, et al. Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes. J Immunol. 2004;173:920-931.
-
(2004)
J Immunol
, vol.173
, pp. 920-931
-
-
Remans, P.H.1
Gringhuis, S.I.2
Van Laar, J.M.3
-
72
-
-
12844270522
-
Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta
-
Buensuceso CS, Obergfell A, Soriani A, et al. Regulation of outside-in signaling in platelets by integrin-associated protein kinase C beta. J Biol Chem. 2005;280:644-653.
-
(2005)
J Biol Chem
, vol.280
, pp. 644-653
-
-
Buensuceso, C.S.1
Obergfell, A.2
Soriani, A.3
-
73
-
-
0032538449
-
Distinct mechanisms mediate the initial and sustained phases of integrinmediated activation of the Raf/MEK/mitogen-activated protein kinase cascade
-
Howe AK, Juliano RL. Distinct mechanisms mediate the initial and sustained phases of integrinmediated activation of the Raf/MEK/mitogen-activated protein kinase cascade. J Biol Chem. 1998;273:27268-27274.
-
(1998)
J Biol Chem
, vol.273
, pp. 27268-27274
-
-
Howe, A.K.1
Juliano, R.L.2
-
74
-
-
0034711221
-
Distinct roles of the adaptor protein shc and focal adhesion kinase in integrin signaling to ERK
-
Barberis L, Wary KK, Fiucci G, et al. Distinct roles of the adaptor protein shc and focal adhesion kinase in integrin signaling to ERK. J Biol Chem. 2000;275:36532-36540.
-
(2000)
J Biol Chem
, vol.275
, pp. 36532-36540
-
-
Barberis, L.1
Wary, K.K.2
Fiucci, G.3
-
75
-
-
0032725309
-
Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades: Evidence for a role of paxillin in c- Jun NH(2)-terminal kinase activation
-
Igishi T, Fukuhara S, Patel V, Katz BZ, Yamada KM, Gutkind JS. Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades: evidence for a role of paxillin in c- Jun NH(2)-terminal kinase activation. J Biol Chem. 1999;274:30738-30746.
-
(1999)
J Biol Chem
, vol.274
, pp. 30738-30746
-
-
Igishi, T.1
Fukuhara, S.2
Patel, V.3
Katz, B.Z.4
Yamada, K.M.5
Gutkind, J.S.6
-
77
-
-
0034724873
-
The association of CRKII with C3G can be regulated by integrins and defines a novel means to regulate the mitogen-activated protein kinases
-
Buensuceso CS, O'Toole TE. The association of CRKII with C3G can be regulated by integrins and defines a novel means to regulate the mitogen-activated protein kinases. J Biol Chem. 2000;275:13118-13125.
-
(2000)
J Biol Chem
, vol.275
, pp. 13118-13125
-
-
Buensuceso, C.S.1
O'Toole, T.E.2
-
78
-
-
0034608787
-
Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor
-
Sheta EA, Harding MA, Conaway MR, Theodorescu D. Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor. J Natl Cancer Inst. 2000;92:1065-1073.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 1065-1073
-
-
Sheta, E.A.1
Harding, M.A.2
Conaway, M.R.3
Theodorescu, D.4
-
79
-
-
0030909050
-
Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway
-
Hughes PE, Renshaw MW, Pfaff M, et al. Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell. 1997;88:521-530.
-
(1997)
Cell
, vol.88
, pp. 521-530
-
-
Hughes, P.E.1
Renshaw, M.W.2
Pfaff, M.3
-
81
-
-
4143118903
-
Rap1 regulates E-cadherin-mediated cell-cell adhesion
-
Price LS, Hajdo-Milasinovic A, Zhao J, Zwartkruis FJ, Collard JG, Bos JL. Rap1 regulates E-cadherin-mediated cell-cell adhesion. J Biol Chem. 2004;279:35127-35132.
-
(2004)
J Biol Chem
, vol.279
, pp. 35127-35132
-
-
Price, L.S.1
Hajdo-Milasinovic, A.2
Zhao, J.3
Zwartkruis, F.J.4
Collard, J.G.5
Bos, J.L.6
-
82
-
-
0030963439
-
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
-
Vossler MR, Yao H, York RD, Pan MG, Rim CS, Stork PJS. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell. 1997;89:73-82.
-
(1997)
Cell
, vol.89
, pp. 73-82
-
-
Vossler, M.R.1
Yao, H.2
York, R.D.3
Pan, M.G.4
Rim, C.S.5
Stork, P.J.S.6
-
83
-
-
10444284084
-
BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells
-
Mizuchi D, Kurosu T, Kida A, et al. BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells. Biochem Biophys Res Commun. 2005;326:645-651.
-
(2005)
Biochem Biophys Res Commun
, vol.326
, pp. 645-651
-
-
Mizuchi, D.1
Kurosu, T.2
Kida, A.3
-
84
-
-
0028986993
-
Expression and activation of B-Raf kinase isoforms in human and murine leukemia cell lines
-
Eychene A, Dusanter-Fourt I, Barnier JV, et al. Expression and activation of B-Raf kinase isoforms in human and murine leukemia cell lines. Oncogene. 1995;10:1159-1165.
-
(1995)
Oncogene
, vol.10
, pp. 1159-1165
-
-
Eychene, A.1
Dusanter-Fourt, I.2
Barnier, J.V.3
-
85
-
-
9144267017
-
B-Raf contributes to sustained extracellular signal-regulated kinase activation associated with interleukin-2 production stimulated through the T cell receptor
-
Tsukamoto H, Irie A, Nishimura Y. B-Raf contributes to sustained extracellular signal-regulated kinase activation associated with interleukin-2 production stimulated through the T cell receptor. J Biol Chem. 2004;279:48457-48465.
-
(2004)
J Biol Chem
, vol.279
, pp. 48457-48465
-
-
Tsukamoto, H.1
Irie, A.2
Nishimura, Y.3
-
86
-
-
4444264392
-
Integrins: Dynamic scaffolds for adhesion and signaling in platelets
-
Shattil SJ, Newman PJ. Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood. 2004;104:1606-1615.
-
(2004)
Blood
, vol.104
, pp. 1606-1615
-
-
Shattil, S.J.1
Newman, P.J.2
-
87
-
-
13844276837
-
The NO/cGMP pathway inhibits Rap 1 activation in human platelets via cGMP-dependent protein kinase I
-
Danielewski O, Schultess J, Smolenski A. The NO/cGMP pathway inhibits Rap 1 activation in human platelets via cGMP-dependent protein kinase I. Thromb Haemost. 2005;93:319-325.
-
(2005)
Thromb Haemost
, vol.93
, pp. 319-325
-
-
Danielewski, O.1
Schultess, J.2
Smolenski, A.3
-
88
-
-
0037441754
-
Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets
-
Larson MK, Chen H, Kahn ML, et al. Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI-mediated Rap1 activation in platelets. Blood. 2003;101:1409-1415.
-
(2003)
Blood
, vol.101
, pp. 1409-1415
-
-
Larson, M.K.1
Chen, H.2
Kahn, M.L.3
-
90
-
-
0030756508
-
Defective platelet activation in G alpha(q)-deficient mice
-
Offermanns S, Toombs CF, Hu YH, Simon MI. Defective platelet activation in G alpha(q)-deficient mice. Nature. 1997;389:183-186.
-
(1997)
Nature
, vol.389
, pp. 183-186
-
-
Offermanns, S.1
Toombs, C.F.2
Hu, Y.H.3
Simon, M.I.4
-
91
-
-
0037189528
-
Activation of Rap1B by G(i) family members in platelets
-
Woulfe D, Jiang H, Mortensen R, Yang J, Brass LF. Activation of Rap1B by G(i) family members in platelets. J Biol Chem. 2002;277:23382-23390.
-
(2002)
J Biol Chem
, vol.277
, pp. 23382-23390
-
-
Woulfe, D.1
Jiang, H.2
Mortensen, R.3
Yang, J.4
Brass, L.F.5
-
92
-
-
0033611139
-
Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling
-
Shiraga M, Ritchie A, Aidoudi S, et al. Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling. J Cell Biol. 1999;147:1419-1430.
-
(1999)
J Cell Biol
, vol.147
, pp. 1419-1430
-
-
Shiraga, M.1
Ritchie, A.2
Aidoudi, S.3
-
93
-
-
0033199619
-
Megakaryocyte growth and development factor-induced proliferation and differentiation are regulated by the mitogen-activated protein kinase pathway in primitive cord blood hematopoietic progenitors
-
Fichelson S, Freyssinier JM, Picard F, et al. Megakaryocyte growth and development factor-induced proliferation and differentiation are regulated by the mitogen-activated protein kinase pathway in primitive cord blood hematopoietic progenitors. Blood. 1999;94:1601-1613.
-
(1999)
Blood
, vol.94
, pp. 1601-1613
-
-
Fichelson, S.1
Freyssinier, J.M.2
Picard, F.3
-
94
-
-
0030866934
-
Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells
-
Racke FK, Lewandowska K, Goueli S, Goldfarb AN. Sustained activation of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway is required for megakaryocytic differentiation of K562 cells. J Biol Chem. 1997;272:23366-23370.
-
(1997)
J Biol Chem
, vol.272
, pp. 23366-23370
-
-
Racke, F.K.1
Lewandowska, K.2
Goueli, S.3
Goldfarb, A.N.4
-
95
-
-
0030871662
-
Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway
-
Rouyez MC, Boucheron C, Gisselbrecht S, Dusanter-Fourt I, Porteu F. Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway. Mol Cell Biol. 1997;17:4991-5000.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 4991-5000
-
-
Rouyez, M.C.1
Boucheron, C.2
Gisselbrecht, S.3
Dusanter-Fourt, I.4
Porteu, F.5
-
96
-
-
0035076221
-
Thrombopoietin-mediated sustained activation of extracellular signal- Regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways
-
Garcia J, de Gunzburg J, Eychene A, Gisselbrecht S, Porteu F. Thrombopoietin-mediated sustained activation of extracellular signal- regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways. Mol Cell Biol. 2001;21:2659-2670.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2659-2670
-
-
Garcia, J.1
De Gunzburg, J.2
Eychene, A.3
Gisselbrecht, S.4
Porteu, F.5
-
97
-
-
0032499282
-
Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
-
York RD, Yao H, Dillon T, et al. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature. 1998;392:622-625.
-
(1998)
Nature
, vol.392
, pp. 622-625
-
-
York, R.D.1
Yao, H.2
Dillon, T.3
-
98
-
-
0030597210
-
Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation
-
Morita H, Tahara T, Matsumoto A, Kato T, Miyazaki H, Ohashi H. Functional analysis of the cytoplasmic domain of the human Mpl receptor for tyrosine-phosphorylation of the signaling molecules, proliferation and differentiation. FEBS Lett. 1996;395:228-234.
-
(1996)
FEBS Lett
, vol.395
, pp. 228-234
-
-
Morita, H.1
Tahara, T.2
Matsumoto, A.3
Kato, T.4
Miyazaki, H.5
Ohashi, H.6
-
99
-
-
0035800782
-
Stromal inhibition of megakaryocytic differentiation correlates with blockade of signaling by protein kinase C-epsilon and ERK/MAPK
-
Goldfarb AN, Delehanty LL, Wang D, Racke FK, Hussaini IM. Stromal inhibition of megakaryocytic differentiation correlates with blockade of signaling by protein kinase C-epsilon and ERK/MAPK. J Biol Chem. 2001;276:29526-29530.
-
(2001)
J Biol Chem
, vol.276
, pp. 29526-29530
-
-
Goldfarb, A.N.1
Delehanty, L.L.2
Wang, D.3
Racke, F.K.4
Hussaini, I.M.5
-
100
-
-
0037369260
-
Stromal inhibition of megakaryocytic differentiation is associated with blockade of sustained Rap1 activation
-
Delehanty LL, Mogass M, Gonias SL, Racke FK, Johnstone B, Goldfarb AN. Stromal inhibition of megakaryocytic differentiation is associated with blockade of sustained Rap1 activation. Blood. 2003;101:1744-1751.
-
(2003)
Blood
, vol.101
, pp. 1744-1751
-
-
Delehanty, L.L.1
Mogass, M.2
Gonias, S.L.3
Racke, F.K.4
Johnstone, B.5
Goldfarb, A.N.6
-
101
-
-
0033152359
-
CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G
-
Arai A, Nosaka Y, Kohsaka H, Miyasaka N, Miura O. CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G. Blood. 1999;93:3713-3722.
-
(1999)
Blood
, vol.93
, pp. 3713-3722
-
-
Arai, A.1
Nosaka, Y.2
Kohsaka, H.3
Miyasaka, N.4
Miura, O.5
-
102
-
-
0032569839
-
C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells
-
de Jong R, van Wijk A, Heisterkamp N, Groffen J. C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells. Oncogene. 1998;17:2805-2810.
-
(1998)
Oncogene
, vol.17
, pp. 2805-2810
-
-
De Jong, R.1
Van Wijk, A.2
Heisterkamp, N.3
Groffen, J.4
-
103
-
-
0035853782
-
Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia
-
Dupuy AJ, Morgan K, von Lintig FC, et al. Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia. J Biol Chem. 2001;276:11804-11811.
-
(2001)
J Biol Chem
, vol.276
, pp. 11804-11811
-
-
Dupuy, A.J.1
Morgan, K.2
Von Lintig, F.C.3
-
104
-
-
0031025185
-
Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human
-
Wada Y, Kubota H, Maeda M, et al. Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human. Genomics. 1997;39:66-73.
-
(1997)
Genomics
, vol.39
, pp. 66-73
-
-
Wada, Y.1
Kubota, H.2
Maeda, M.3
-
105
-
-
15944404601
-
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
-
Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood. 2005;105:2640-2653.
-
(2005)
Blood
, vol.105
, pp. 2640-2653
-
-
Deininger, M.1
Buchdunger, E.2
Druker, B.J.3
-
106
-
-
0035866343
-
Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice
-
Hemmeryckx B, van Wijk A, Reichert A, et al. Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice. Cancer Res. 2001;61:1398-1405.
-
(2001)
Cancer Res
, vol.61
, pp. 1398-1405
-
-
Hemmeryckx, B.1
Van Wijk, A.2
Reichert, A.3
-
107
-
-
0035120788
-
Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells
-
Grumbach IM, Mayer IA, Uddin S, et al. Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells. Br J Haematol. 2001;112:327-336.
-
(2001)
Br J Haematol
, vol.112
, pp. 327-336
-
-
Grumbach, I.M.1
Mayer, I.A.2
Uddin, S.3
-
108
-
-
0030892028
-
The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins
-
Uemura N, Salgia R, Li J, Pisick E, Sattler M, Griffin J. The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins. Leukemia. 1997;11:376-385.
-
(1997)
Leukemia
, vol.11
, pp. 376-385
-
-
Uemura, N.1
Salgia, R.2
Li, J.3
Pisick, E.4
Sattler, M.5
Griffin, J.6
-
109
-
-
1242307380
-
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis
-
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA. JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia. 2004;18:189-218.
-
(2004)
Leukemia
, vol.18
, pp. 189-218
-
-
Steelman, L.S.1
Pohnert, S.C.2
Shelton, J.G.3
Franklin, R.A.4
Bertrand, F.E.5
McCubrey, J.A.6
-
110
-
-
0033603578
-
Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion
-
Tsukamoto N, Hattori M, Yang H, Bos JL, Minato N. Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. J Biol Chem. 1999;274:18463-18469.
-
(1999)
J Biol Chem
, vol.274
, pp. 18463-18469
-
-
Tsukamoto, N.1
Hattori, M.2
Yang, H.3
Bos, J.L.4
Minato, N.5
-
111
-
-
0036299166
-
The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1
-
Lekmine F, Sassano A, Uddin S, et al. The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1. Biochem Biophys Res Commun. 2002;291:744-750.
-
(2002)
Biochem Biophys Res Commun
, vol.291
, pp. 744-750
-
-
Lekmine, F.1
Sassano, A.2
Uddin, S.3
-
113
-
-
0141815787
-
Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy
-
Dillon TJ, Karpitski V, Wetzel SA, Parker DC, Shaw AS, Stork PJ. Ectopic B-Raf expression enhances extracellular signal-regulated kinase (ERK) signaling in T cells and prevents antigen-presenting cell-induced anergy. J Biol Chem. 2003;278:35940-35949.
-
(2003)
J Biol Chem
, vol.278
, pp. 35940-35949
-
-
Dillon, T.J.1
Karpitski, V.2
Wetzel, S.A.3
Parker, D.C.4
Shaw, A.S.5
Stork, P.J.6
-
114
-
-
0141591492
-
Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice
-
U S A
-
Ishida D, Yang H, Masuda K, et al. Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice. Proc Natl Acad Sci U S A. 2003;100:10919-10924.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 10919-10924
-
-
Ishida, D.1
Yang, H.2
Masuda, K.3
-
115
-
-
0032570874
-
Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes
-
Reedquist KA, Bos JL. Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes. J Biol Chem. 1998;273:4944-4949.
-
(1998)
J Biol Chem
, vol.273
, pp. 4944-4949
-
-
Reedquist, K.A.1
Bos, J.L.2
-
116
-
-
18044405159
-
Regulation of the small GTPase Rap1 and ERKs by the costimulatory molecule CTLA-4
-
Dillon TJ, Carey KD, Wetzel SA, Parker DC, Stork PJS. Regulation of the small GTPase Rap1 and ERKs by the costimulatory molecule CTLA-4. Mol Cell Biol. 2005;25:4117-4128.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4117-4128
-
-
Dillon, T.J.1
Carey, K.D.2
Wetzel, S.A.3
Parker, D.C.4
Stork, P.J.S.5
-
117
-
-
0029952223
-
Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways
-
DeSilva DR, Feeser WS, Tancula EJ, Scherle PA. Anergic T cells are defective in both jun NH2-terminal kinase and mitogen-activated protein kinase signaling pathways. J Exp Med. 1996;183:2017-2023.
-
(1996)
J Exp Med
, vol.183
, pp. 2017-2023
-
-
DeSilva, D.R.1
Feeser, W.S.2
Tancula, E.J.3
Scherle, P.A.4
-
118
-
-
0030707866
-
Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70
-
Calvo CR, Amsen D, Kruisbeek AM. Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70. J Exp Med. 1997;186:1645-1653.
-
(1997)
J Exp Med
, vol.186
, pp. 1645-1653
-
-
Calvo, C.R.1
Amsen, D.2
Kruisbeek, A.M.3
-
121
-
-
0030701952
-
Distinct roles for LFA-1 and CD28 during activation of naive T cells: Adhesion versus costimulation
-
Bachmann MF, McKall-Faienza K, Schmits R, et al. Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity. 1997;7:549-557.
-
(1997)
Immunity
, vol.7
, pp. 549-557
-
-
Bachmann, M.F.1
McKall-Faienza, K.2
Schmits, R.3
-
122
-
-
1642581670
-
LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds
-
Kinashi T, Aker M, Sokolovsky-Eisenberg M, et al. LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds. Blood. 2004;103:1033-1036.
-
(2004)
Blood
, vol.103
, pp. 1033-1036
-
-
Kinashi, T.1
Aker, M.2
Sokolovsky-Eisenberg, M.3
-
123
-
-
0034459505
-
Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases ras and rap1
-
Czyzyk J, Leitenberg D, Taylor T, Bottomly K. Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases ras and rap1. Mol Cell Biol. 2000;20:8740-8747.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8740-8747
-
-
Czyzyk, J.1
Leitenberg, D.2
Taylor, T.3
Bottomly, K.4
-
124
-
-
0033606980
-
Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)
-
Mochizuki N, Ohba Y, Kiyokawa E, et al. Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i). Nature. 1999;400:891-894.
-
(1999)
Nature
, vol.400
, pp. 891-894
-
-
Mochizuki, N.1
Ohba, Y.2
Kiyokawa, E.3
-
125
-
-
19644386691
-
Diacylglycerol kinase {iota} regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling
-
U S A
-
Regier DS, Higbee J, Lund KM, Sakane F, Prescott SM, Topham MK. Diacylglycerol kinase {iota} regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Proc Natl Acad Sci U S A. 2005;102:7595-7600.
-
(2005)
Proc Natl Acad Sci
, vol.102
, pp. 7595-7600
-
-
Regier, D.S.1
Higbee, J.2
Lund, K.M.3
Sakane, F.4
Prescott, S.M.5
Topham, M.K.6
-
126
-
-
23844460509
-
Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo
-
Li L, Greenwald RJ, Lafuente EM, et al. Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo. J Immunol. 2005;175:3133-3139.
-
(2005)
J Immunol
, vol.175
, pp. 3133-3139
-
-
Li, L.1
Greenwald, R.J.2
Lafuente, E.M.3
-
127
-
-
24644506094
-
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternative basis for coreceptor function
-
U S A
-
Schneider H, Valk E, da Rocha Dias S, Wei B, Rudd CE. CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternative basis for coreceptor function. Proc Natl Acad Sci U S A. 2005;102:12861-12866.
-
(2005)
Proc Natl Acad Sci
, vol.102
, pp. 12861-12866
-
-
Schneider, H.1
Valk, E.2
Da Rocha Dias, S.3
Wei, B.4
Rudd, C.E.5
|