CD28 and the tyrosine kinase Lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1

Molecular and Cellular Biology

Volumn 20, Issue 22, 2000, Pages 8409-8419

  Carey, K D ^a   Dillon, T J ^a   Schmitt, J M ^a   Baird, A M ^a   Holdorf, A D ^a   Straus, D B ^a   Shaw, A S ^a   Stork, P J S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD3; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; JURKAT CELLS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; RAP1 GTP-BINDING PROTEINS; RAS PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES;

EID: 0033756553     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.22.8409-8419.2000     Document Type: Article

References (79)

1. Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes
2. Ras protein activity is essential for T-cell antigen receptor signal transduction
3. Mutational analysis of CD28-mediated costimulation of Jun-N-terminal kinase and IL-2 production
4. Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1
5. cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor
6. Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
7. The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP
8. Inhibition by cAMP of ras-dependent activation of raf
9. Regulation of T-cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)
10. CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection
11. The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling
12. Differential T-cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn
13. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
14. A synthetic inhibitor of the mitogen-activated protein kinase cascade
15. MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products
16. Costimulation: Building an immunological synapse
17. Regulation of interleukin-2 transcription by inducible stable expression of dominant negative and dominant active mitogen-activated protein kinase kinase kinase in jurkat T cells. Evidence for the importance of Ras in a pathway that is controlled by dual receptor stimulation
18. Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs
19. Blocked Ras activation in anergic CD4+ T cells
20. 2+-mediated activation of rap1 in human platelets
21. A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum
22. Ras regulation and function in lymphocytes
23. Multiple p21ras effector pathways regulate nuclear factor of activated T cells
24. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G
25. Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase (PKA)
26. Extracellular-signal-regulated kinase signalling in neurons
27. Costimulation in tolerance and autoimmunity
28. Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection
29. Lck activity controls CD4/CD8 T cell lineage commitment
30. The crystal structure of rna1p: A new fold for a GTPase-activating protein
31. Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation
32. cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts
33. Nocodazole inhibits signal transduction by the T cell antigen receptor
34. The role of Raf-1 in the regulation of extracellular signal-regulated kinase 2 by the T cell antigen receptor
35. Modulation of Rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein
36. Genetic analysis of the Kirsten-ras-revertant 1 gene: Potentiator of its tumor suppressor activity by specific point mutations
37. A ras-related gene with transformation suppressor activity
38. Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product
39. From TCR engagement to T cell activation: A kinetic view of T cell behavior
40. CD28/B7 system of T cell costimulation
41. A dominant-negative transgene defines a role for p56lck in thymopoiesis
42. Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T-cells
43. Nerve growth factor stimulation of the Ras-guanine nucleotide exchange factor and GAP activities
44. CD3- and CD28-dependent induction of PDE7 required for T cell activation
45. Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells
46. Targets of p56(lck) activity in immature thymoblasts: Stimulation of the Ras/Raf/MAPK pathway
47. Increased cyclic adenosine monophosphate levels block progression but not initiation of human T cell proliferation
48. Costimulation of murine CD4 T cell growth: Cooperation between B7 and heat-stable antigen
49. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
50. Activation of the Rap1 GTPase by the B cell antigen receptor
51. Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)
52. The role of p21ras in CD28 signal transduction: Triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras
53. The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases
54. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
55. Phosphorylation of rap1GAP in vivo and by cAMP-dependent kinase and the cell cycle p34(cdc2) kinase in vitro
56. Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells
57. p21ras mediates control of IL-2 gene promoter function in T cell activation
58. Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes
59. The small GTPase, Rap1, mediates CD31-induced integrin adhesion
60. Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21(rap1)
61. smg/rap1/Krev-1 p21 inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells
62. β2-adrenergic receptor activates extracellular regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf
63. The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
64. Making the T cell receptor go the distance: A topological view of T cell activation
65. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
66. SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction
67. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
68. Immunohistochemical evidence for DNA fragmentation in neurons in the AD brain
69. CD28 affects the earliest signaling events generated by TCR engagement
70. Two adjacent promoter elements mediate nerve growth factor activation of the c-fos gene and bind distinct nuclear complexes
71. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
72. Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells
73. A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity
74. Oncogenic ras activates c-jun via a separate pathway from the activation of extracellular signal-regulated kinases
75. MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells
76. Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity
77. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate
78. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
79. Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling