PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1

Molecular Cell

Volumn 9, Issue 1, 2002, Pages 85-94

  Schmitt, John M ^a   Stork, Philip J S ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CBL PROTEIN; CYCLIC AMP; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN SRC; RAP PROTEIN; SERINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; FIBROBLAST; GROWTH INHIBITION; IN VIVO STUDY; MOUSE; NONHUMAN; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA;

EID: 0036161707     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00432-4     Document Type: Article

References (54)

1. Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin
2. Cyclic AMP-dependent activation of Rap1b
3. Src family tyrosine kinases participate in insulin-like growth factor I mitogenic signaling in 3T3-L1 cells
4. Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases
5. Rap1 signalling: Adhering to new models
6. Maintenance of human T cell anergy: Blocking of IL-2 gene transcription by activated Rap1
7. Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling
8. Regulation, substrates and functions of Src
9. cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor
10. The effect of cyclic adenosine monophosphate on the mitogen-activated protein kinase pathway depends on both the cell type and the type of tyrosine kinase-receptor
11. Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation
12. Suppression of Ras-induced transformation of NIH 3T3 cells by activated Gαs
13. Elevation of cyclic adenosine 3′,5′-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells
14. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-Bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells
15. Structural analysis of the avian sarcoma virus transforming protein: Sites of phosphorylation
16. Inhibition by cAMP of Ras-dependent activation of Raf
17. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts
18. Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of pp60src are dispensable for transformation
19. A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions
20. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A
21. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
22. G protein-coupled receptor systems involved in cell growth and oncogenesis
23. Differential effects of cAMP in neurons and astrocytes. Role of B-raf
24. 2+-mediated activation of rap1 in human platelets
25. Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells
26. Regulation of carbamoyl phosphate synthetase by MAP kinase
27. Extracellular-signal-regulated kinase signalling in neurons
28. Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase (PKA)
29. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
30. Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation
31. A ras-related gene with transformation suppressor activity
32. Src family kinases are required for integrin but not PDGFR signal transduction
33. Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk
34. Src tyrosine kinase is a novel direct effector of G proteins
35. DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases
36. Cyclic AMP treatment of Rous sarcoma virus-transformed Chinese hamster ovary cells increases phosphorylation of pp60src and increases pp60src kinase activity
37. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
38. β2-adrenergic receptor activates extracellular regulated kinases (ERKs) via the small G protein Rap1 and the serine/threonine kinase B-Raf
39. Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1
40. Increasing cAMP attenuates activation of mitogen-activated protein kinase
41. Phosphorylation of serine 43 is not required for inhibition of C-Raf kinase by the cAMP-dependent protein kinase
42. Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways
43. Inhibition of T lymphocyte activation by cAMP is associated with down-regulation of two parallel mitogen-activated protein kinase pathways, the extracellular signal-related kinase and c-Jun N-terminal kinase
44. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins
45. Determination of cyclic nucleotide-dependent protein kinase substrate specificity by the use of peptide libraries on cellulose paper
46. Cbl: Many adaptations to regulate protein tyrosine kinases
47. Cellular functions regulated by Src family kinases
48. Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A
49. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
50. Translocation of pp60c-src from the plasma membrane to the cytosol after stimulation by platelet-derived growth factor
51. Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells
52. Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3′, 5′-monophosphate
53. c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase
54. Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gsα