Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells

Journal of Neuroscience

Volumn 18, Issue 24, 1998, Pages 10277-10286

  Castilho, Roger F ^a   Hansson, Oskar ^b   Ward, Manus W ^c   Budd, Samantha L ^d   Nicholls, David G ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c LUND UNIVERSITY   (Sweden)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Calcium; Excitotoxicity; Glutamate; Granule cell; Mitochondria; NMDA

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM 45; CYCLOSPORIN A; GLUTAMIC ACID; GLYCINE; KETAMINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NIFEDIPINE; OLIGOMYCIN; ROTENONE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CEREBELLUM; CONTROLLED STUDY; GRANULE CELL; MITOCHONDRIAL RESPIRATION; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0032535275     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-24-10277.1998     Document Type: Article

References (5)

1. Ankarcrona M, Dypbukt JM, Orrenius S, Nicotera P (1996) Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett 394:321-324.
2. Beal MF (1996) Mitochondria, free radicals, and neurodegeneration. Curr Opin Neurobiol 6:661-666.
3. Beal MF, Howell N, Bodis-Wollner I (1997) Mitochondria and free radicals in neurodegenerative disease. New York: Wiley-Liss.
4. Bernardi P, Petronilli V (1996) The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal. J Bioenerg Biomembr 28:131-138.
5. Bossy-Wetzel E, Newmeyer DD, Green DR (1998) Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J 17:37-49.