Cyclin D1 overexpression in mouse epidermis increases cyclin-dependent kinase activity and cell proliferation in vivo but does not affect skin tumor development

Cell Growth and Differentiation

Volumn 10, Issue 7, 1999, Pages 467-472

  Rodriguez Puebla, Marcelo L ^a   LaCava, Margaret ^a   Conti, Claudio J ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; LABELING INDEX; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN TUMOR; TRANSGENIC MOUSE; TUMOR GROWTH;

ANIMALS; BLOTTING, WESTERN; CARCINOGENS; CELL DIVISION; CYCLIN D1; CYCLIN-DEPENDENT KINASES; GENES, RAS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; PRECIPITIN TESTS; SKIN; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA; MUS MUSCULUS;

EID: 0032789831     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Nurse, P. Ordering S phase and M phase in the cell cycle. Cell, 79: 547-550, 1994.
2. Hartwell, L. H., and Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events. Science (Washington DC), 246: 629-634, 1989.
3. 1 cyclins. Cell, 73: 1059-1065, 1993.
4. 1 phase progression: cyclin on cue. Cell, 79: 551-555, 1994.
5. 1 phase of the human cell-cycle. Science (Washington DC), 257: 1689-1693, 1992.
6. Labbe, J. C., Picard, A., Peaucellier, G., Cavadore, J. C., Nurse, P., and Doree, M. Purification of MPF from starfish: identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation. Cell, 57: 253-263, 1989.
7. Guan, K. L, Jenkins, C. W., Li, Y., Nichols, M. A., Wu, X., O'Keefe, C., Matera, A. G., and Xiong, Y. Growth suppression by p18, a p16 and p15 related CDK6 inhibitor, correlates with wild-type pRb functions. Genes Dev., 8: 2939-2952, 1994.
8. Hannon, G. J., and Beanch, D. p15INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature (Lond.), 371: 257-261, 1994.
9. Demers, G. W., Foster, S. A., Halbert, C. L., and Calloway, D. A. Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. Proc. Natl. Acad. Sci. USA, 91: 4382-4386, 1994.
10. Sherr, C. J. D-typecyclins, Trends Biochem. Sci., 20: 187-190, 1995.
11. Munger, K., Pietempol, J. A., Pittelkow, M. R., Holt, J. T., and Moses, H. L Transforming growth factor B1 regulation of c-myc expression, pRb phosphorylation, and cell cycle progression in keratinocytes. Cell Growth Differ., 3: 291-298, 1992.
12. Nevins, J. R. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science (Washington DC), 258: 424-429, 1992.
13. Kress, S., Sutler, C., Strickland, P. T., Mukhtar, H., Schweizer, J., and Schwarz, M. Carcinogen-specific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinosmas of mouse skin. Cancer Res., 52: 6400-6403, 1992.
14. Ruggeri, B., Caamano, J., and Goodrow, T. Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res., 51: 6615-6621, 1991.
15. Robles, A. I., and Conti, C. J. Early overexpressiori of cyclin D1 protein in mouse skin carcinogenesis. Carcinogenesis (Lond.), 16: 781-786, 1995.
16. Bianchi, A. B., Fischer, S. M., Robles, A. I., Rinchik, E. M., and Conti, C. J. Overexpression of cyclin D1 in mouse skin carcinogenesis. Oncogene, 8: 1127-1133, 1993.
17. Robles, A. I., Larcher, E., Whalin, R. B., Murillas, R., Richie, E., Gimenez-Conti, I. B., Jorcano, J. L., and Conti, C. J. Expression of Cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia. Proc. Natl. Acad. Sci. USA, 93; 7634-7638, 1996.
18. Robles, A. I., Rodriguez-Puebla, M. L., Glick, A. B., Trempus, C., Hansen, L., Sicinski, P., Tennant, R. W., Weinberg, R. A., Yuspa, S. H., and Conti, C. J. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev., 12: 2469-2474, 1998.
19. Rodriguez-Pusbla, M. L, LaCava, M., Gimenez-Conti, I. B., Jonhson, D. G., and Conti, C. J. Deregulated expression of cell-cycle proteins during premalignant progression in SENCAR mouse skin. Oncogene, 17: 2251-2258, 1998.
20. Rodriguez-Puebla, M. L., Robles, A. I., Johnson, D. G., LaCava, M., and Conti, C. J. Synchronized proliferation induced by TPA treatment of mouse skin: an in vivo model for cell cycle regulation. Cell Growth Differ., 9: 31-39, 1998.
21. Rodriguez-Puebla, M. L., Robles, A. I., and Conti, C. J. Ras activity and cyclin D1 expression: an essential mechanism of mouse skin tumor development. Mol. Carcinog., 24: 1-6, 1999.
22. Balmain, A., and Pragnell, I. Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature (Lond.), 303: 72-74, 1983.
23. Bizub, D., Wood, A., and Skalka, A. Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons. Proc. Natl. Acad. Sci. USA, 83: 6048-6052, 1986.
24. Quintanilla, M., Brown, K., Ramsden, M., and Balmain, A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature (Lond.), 322: 78-80, 1986.
25. Roop, D., Lowy, D., Tambourin, P., Strickland, J., Harper, J., Balaschak, M., Spangler, E., and Yuspa, S. An activated Harvey ras oncogene produces benign tumors on mouse epidermal tissue. Nature (Lond.), 323: 822-824, 1986.
26. Pierce, A. M., Fischer, S., Conti, C. J., and Johnson, D. G. Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development. Oncogene, 16: 1267-1276, 1998.
27. Jiang, W., Kahn, S., Zhou, P., Zhang, Y., Cacace, A., Infante, A., Doi, S., Santella, R., and Weinstein, I. Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene, 8: 3447-3457, 1993.
28. Imoto, M., Doki, Y., Jiang, W., Man, E. K., and Weinstein, I. B. Effects of cyclin D1 overexpression on G1 progression-related events. Exp. Cell Res., 236: 173-180, 1997.
29. 1 to complete the cell cycle. Proc. Natl. Acad. Sci. USA, 91: 8022-8026, 1994.
30. Walker, D. H., and Mailer, J. L Role for cyclin A in the dependence of mitosis on completion of DNA replication. Nature (Lond.), 354: 314-317, 1991.
31. Girard, F., Strausfeld, U., Fernandez, A., and Lamb, N. J. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell, 67: 1169-1179, 1991.
32. Desdouets, C., Sobczak-Thepot, J., Murphy, M., and Brachot, C. Cyclin A: function and expression during cell proliferation. Prog. Cell Cycle Res., 1: 115-123, 1995.
33. Zindy, F., Lamas, E., Chenivesse, X., Sobczak, J., Wang, J., Fesquet, D., Menglein, B., and Brechet, C. Cyclin A is required in S phase in normal epithelial cells. Biochem. Biophys. Res. Commun., 182: 1144-1154, 1992.
34. Di Cunto, F., Topley, G., Calautti, E., Hsiao, J., Ong, L, Seth, P. K., and Dotto, G. P. Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science (Washington DC), 280: 1069-1072, 1998.
35. Quo, K., Wang, J., Andres, V., Smith, R., and Walsh, K. MyoD-induced expression of p21 inhibits cyclin-dependent kinase activity upon myocyte terminal differentiation. Mol. Cell. Biol., 15: 3823-3829, 1995.
36. Jiang, H., Lin, J., Su, Z., Collar, F. R., Huberman, E., and Fisher, P. B. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21/WAF1/CIP1, expression in the absence of p53. Oncogene, 9: 3397-3406, 1994.
37. Parker, S. B., Eichele, G., Zhang, P., Rawls, A., Sands, A. T., Bradley, A., Olson, E. N., Harper, J. W., and Elledge, S. J. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (Washington DC), 267: 1024-1027, 1995.
38. Labaer, J., Garret, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., and Harlow, E. New functional activities for the p21 family of CDK inhibitors. Genes Dev., 11: 847-862, 1997.
39. Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., and Beach, D. p21 is a universal inhibitor of cyclin kinases. Nature (Lond.), 366: 701-704, 1993.
40. Xiong, Y. Why are there so many CDK inhibitors? Biochim. Biophys. Acta, 1288: 1-5, 1996.
41. Nevins, J., Chellappan, S., Mudryj, M., Hiebert, S., Devoto, S., Horowitz, J., Hunter, T., and Pines, J. E2F transcription factor is a target for the RB protein and the cyclin A protein. Cold Spring Harb. Symp. Quant. Biol., 56: 157-162, 1991.
42. Jiang, W., Zhang, Y-J., Khan, S. M., Hollstein, M. C., Santella, R. M., Lu, S. H., Harris, C. C., Montesano, R., and Weinstein, I. B. Altered expression of the cyclin D1 and retinoblastome genes in human esophageal cancer. Proc. Natl. Acad. Sci. USA, 90: 9026-9030, 1993.
43. Bartkova, J., Lukas, J., Strauss, M., and Bartek, J. The PRAD1/cyclin D1 oncogene product accumulate aberrantly in a subset of colorectal carcinomas. Int. J. Cancer, 58: 568-573, 1994.
44. Schauer, I. E., Siriwardana, S., Langan, T. A., and Sclafani, R. A. Cyclin D1 overexpression versus retinoblastoma inactivation: implications for growth control evasion in non-small cell and small cell lung cancer. Proc. Natl. Acad. Sci. USA, 91: 7827-7831, 1994.