The Plant Isoflavenoid Genistein Activates p53 and Chk2 in an ATM-dependent Manner

Journal of Biological Chemistry

Volumn 276, Issue 7, 2001, Pages 4828-4833

  Ye, Ruiqiong ^a   Bodero, Amanda ^a   Zhou, Bin Bing ^b   Khanna, Kum Kum ^c   Lavin, Martin F ^c   Lees Miller, Susan P ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b SmithKline Beecham Pharmaceutical ^*  (United States)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYMES; NUTRITION; PLANTS (BOTANY); PROTEINS; TUMORS;

BREAST CANCERS;

BIOCHEMISTRY;

ATM PROTEIN; CHECKPOINT KINASE 2; ETOPOSIDE; GENISTEIN; GYRASE INHIBITOR; ISOFLAVONOID; PROTEIN KINASE; PROTEIN P53; PROTEIN TYROSINE KINASE INHIBITOR; SERINE; THREONINE; UNCLASSIFIED DRUG; ANDROSTANE DERIVATIVE; BENZOQUINONE DERIVATIVE; CAFFEINE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; DNA FRAGMENT; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR; HERBIMYCIN; MACROCYCLIC LACTAM; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; QUINONE DERIVATIVE; TUMOR SUPPRESSOR PROTEIN; WORTMANNIN;

ARTICLE; BREAST CANCER; CANCER INCIDENCE; CELL KILLING; CONTROLLED STUDY; COVALENT BOND; DIET; DNA DAMAGE; GENE ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SOYBEAN; CELL LINE; DRUG ANTAGONISM; GENETICS; MEDICINAL PLANT; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY;

GLYCINE MAX;

ANDROSTADIENES; BENZOQUINONES; CAFFEINE; CELL CYCLE PROTEINS; CELL LINE; DNA FRAGMENTATION; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; ENZYME INHIBITORS; ETOPOSIDE; GENISTEIN; HUMANS; LACTAMS, MACROCYCLIC; MUTATION; PHOSPHORYLATION; PLANTS, MEDICINAL; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; QUINONES; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 0035895895     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M004894200     Document Type: Article

References (55)

1. Hsieh, C.-Y., Santell, R. C., Haslam, S. Z., and Helferich, W. G. (1988) Cancer Res. 58, 3833-3838
2. Adlercreutz, H., Mousavi, Y., Clark, J. Hockerstedt, K., Hamaleinen, E., Wahala, K., Makela, T., and Hase, T. (1992) J. Steroid Biochem. Mol. Biol. 41, 331-337
3. Miksicek, R. J. (1993) Mol. Pharmacol. 4, 37-43
4. Lee, H. P., Gourley, L., Duffy, S. W., Esteve, J., Lee, J., and Day, N. E. (1991) Lancet 337, 1197-1200
5. Messina, M. J., Persky, V., Setchell, K. D., and Barnes, S. (1994) Nutr. Cancer 21, 113-131
6. Gescher, A., Pastorino, U., Plummer, S. M., and Manson, M. M. (1998) Br. J. Clin. Pharmacol. 45, 1-12
7. Lamartiniere, C. A., Moore, J., Holland, M., and Barnes, S. (1995) Proc. Soc. Exp. Biol. Med. 208, 120-123
8. Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., Watanabe, S.-I., Itoh, N., Shibuya, M., and Fukami, Y. (1987) J. Biol. Chem. 262, 5592-5595
9. Markovits, J., Linassier, C., Fosse, P., Couprie, J., Pierre, J., Jacquemin-Sablon, A., Saucier, J.-M., Le Pecq, J.-B., and Larsen, A. K. (1989) Cancer Res. 49, 5111-5117
10. McCabe, M. J., and Orrenius, S. (1993) Biochem. Biophys. Res. Commun. 194, 944-950
11. Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., and Moon, R. (1995) J. Nat. Prod. 58, 217-225
12. Gorczyca, W., Gong, J., Ardelt, B., Traganos, F., and Darzynkiewicz, Z. (1993) Cancer Res. 53, 3186-3192
13. Li, Y., Upadhyay, S., Bhuiyan, M., and Sarkar, F. H. (1999) Oncogene 18, 3166-3172
14. Balabhadrapathruni, S., Thomas, T. J., Yurkow, E. J., Amenta, P. S., and Thomas, T. (2000) Oncol. Reports 7, 3-12
15. Kaufmann, S. H., Desnoyers, S., Ottaviano, Y., Davidson, N. E., and Poirier, G. G. (1993) Cancer Res. 53, 3976-3985
16. Casciola-Rosen, L. A., Anhalt, G. J., and Rosen, A. (1995) J. Exp. Med. 182, 1625
17. Casciola-Rosen, L., Nicholson, D. W., Chong, T., Rowan, K. R., Thornberry, N. A., Miller, D. K., and Rosen, A. (1996) J. Exp. Med. 183, 1957-1964
18. Song, Q., Lees-Miller, S. P., Kumar, S., Zhang, N., Chan, D. W., Smith, G. C. M., Jackson, S. P., Alnemri, E. S., Litwack, G., Khanna, K. K., and Lavin, M. F. (1996) EMBO J. 15, 3238-3246
19. Smith, G. C. M., di Fagagna, F d'A., Lakin, N. D., and Jackson, S. P. (1999) Mol. Cell. Biol. 19, 6076-6084
20. Nicholson, D. W., and Thornberry, N. A. (1997) Trends Biochem. Sci. 22, 299-306
21. Hunter, T. (1995) Cell 83, 1-4
22. Zakian, V. A. (1995) Cell 82, 685-687
23. Lavin, M. F., and Shiloh, Y. (1997) Annu. Rev. Immunol. 15, 177-202
24. Hartley, K. O., Gell, D., Smith, G. C. M., Zhang, H., Divecha, N., Connelly, M. A., Admon, A., Lees-Miller, S. P., Anderson, C. W., and Jackson, S. P. (1995) Cell 82, 849-856
25. Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., Ashkenazi, M., Pecker, I., Frydman, M., Harnik, R., Patanjali, S. R., Simmons, A., Clines, G. A., Sartuiel, A., Gatti, R. A., Chessa, L., Sanal, O., Lavin, M. F., Jaspers, N. G. J., Taylor, M. R., Arlett, C. F., Miki, T., Weissman, S. M., Lovett, M., Collins, F. S., and Shiloh, Y. (1995) Science 268, 1749-1753
26. Savitsky, K., Sfez, S., Tagle, D. A., Sartiel, A., Collins, F. S., Shiloh, Y., and Rotman, G. (1995) Hum. Mol. Genet. 4, 2025-2032
27. Houndsworth, J., and Lavin, M. F. (1980) Nucleic Acids Res. 8, 3709-3720
28. Painter, R. B., and Young, B. R. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 7315-7317
29. Nakamura, Y. (1998) Nat. Med. 4, 1231-1232
30. Canman, C. E., and Lim, D-S. (1998) Oncogene 17, 3301-3308
31. Matsuoka, S., Huang, M., and Elledge, S. J. (1998) Science 282, 1893-1987
32. Chaturvedi, P., Eng, W. K., Zhu, Y., Mattern, M. R., Mishra, R., Hurle, M. R., Zhang, X., Annan R. S., Lu, Q., Faucette, L. F., Scott, G. F., Li X., Carr, S. A., Johnson, R. K., Winkler, J. D. and Zhou, B. B. (1999) Oncogene 18, 4047-4054
33. Banin, S., Moyal, L., Shieh, S., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reis, Y., Shiloh, Y., and Ziv, Y. (1998) Science 281, 1674-1677
34. Canman, C. E., Lim, D-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., Siliciano, J. D. (1998) Science 281, 1677-1679
35. Chan, D. W., Son, S-C., Block, W., Ye, R., Douglas, P., Goodarzi, A. A., Pelley, J., Khanna, K. K., Taya, Y., Lavin M. F., and Lees-Miller, S. P. (2000) J. Biol. Chem. 275, 7803-7810
36. Khanna, K. K and Lavin, M. F. (1993) Oncogene 8, 3307-3312
37. Khanna, K. K., Keating, K., Kozlov, S., Scott, S., Gatei, M., Hobson, B., Gabrielli, B., Chan, D. W., Lees-Miller, S. P., and Lavin, M. F. (1998) Nat. Genet. 20, 398-400
38. Lees-Miller, S. P., Sakaguchi, K., Ullrich, S., Appella, E., and Anderson, C. W. (1992) Mol. Cell. Biol. 12, 5041-5049
39. Lees-Miller, S. P., Chen, Y-R., and Anderson, C. W. (1990) Mol. Cell. Biol. 10, 6472-6481
40. Woo, R. A., McLure, K. G., Lees-Miller, S. P., Rancourt, D. E., and Lee, P. W. K. (1998) Nature 394, 700-704
41. Ting, N. S. Y., Kao, P. N., Chan, D. W., Lintott, L. G., and Lees-Miller, S. P. (1998) J. Biol. Chem. 273, 2136-2145
42. Chan, D. W., and Lees-Miller, S. P. (1996) J. Biol. Chem. 271, 8936-8941
43. Zhou, B. B., Chaturvedi, P., Spring, K., Scott, S. P., Johanson, R. A., Mishra, R., Mattern, M. R., Winkler, J. D., and Khanna, K. K. (2000) J. Biol. Chem. 275, 10342-10348
44. Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., and Elledge, S. J. (2000) Proc. Natl. Acad. Sci. U. S. A 97, 10389-10394
45. Sarkaria, J. N., Busby, E. C., Tibbetts, R. S., Roos, P., Taya, Y., Karnitz, L. M., and Abraham, R. T. (1999) Cancer Res. 59, 4375-4382
46. Blasina, A., Price, B. D., Turenne, G. A., and McGowan, C. H. (1999) Curr. Biol. 9, 1135-1138
47. Lakin, N. D., Hann, B. C., and Jackson, S. P. (1999) Oncogene 18, 3989-3995
48. Kharbanda, S., Yuan, Z. M., Taneja, N., Weichselbaum, R., and Kufe, D. (1994) Oncogene 9, 3005-30011
49. Becker, B. N., Kondo, S., Chen, J. K., and Harris, R. C. (1999) J. Recept. Signal Transduct. Res, 19, 975-93
50. Hu, P. P., Shen, X., Huang, D., Liu, Y., Counter, C., and Wang, X. F. (1999) J. Biol. Chem. 274, 35381-35387
51. Darbon, J-M., Penary, M., Escalas, N., Casagrande, F., Goubin-Gramatica, F., Baudouin, C., and Ducommun, B. (2000) J. Biol. Chem. 275, 15363-15369
52. Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., and Abraham, R. T. (1999) Genes Dev. 13, 152-157
53. Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., and Friend, S. H. (1998) EMBO J. 17, 159-169
54. Shafman, T., Khanna, K. K., Kedar, P., Spring, K., Kozlov, S. Yen, T., Hobson, K., Gatei, M., Zhang, N., Watters, D., Egerton, M., Shiloh, Y., Kharbanda, S., Kufe, D., and Lavin, M. F. (1997) Nature 387, 520-523
55. Baskaran, R., Wood, L. D., Whitaker, L. L., Canman, C. E., Morgan, S. E., Xu, Y., Barlow C., Baltimore, D., Wynshaw-Boris, A., Kastan, M. B., and Wang J. Y. (1997) Nature 387, 516-519