Molecular dynamics of a food carcinogen-DNA adduct in a replicative DNA polymerase suggest hindered nucleotide incorporation and extension

Chemical Research in Toxicology

Volumn 18, Issue 9, 2005, Pages 1347-1363

  Zhang, Ling ^a   Shapiro, Robert ^a   Broyde, Suse ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; DNA POLYMERASE; HETEROCYCLIC AMINE; NUCLEOTIDE;

ARTICLE; CARCINOGEN DNA INTERACTION; COLON TUMOR; DIETARY INTAKE; DNA CONFORMATION; ENZYME ANALYSIS; GENE MUTATION; HUMAN; HYDROGEN BOND; IN VIVO STUDY; MOLECULAR DYNAMICS; PROTEIN INTERACTION; SIMULATION; TREATMENT OUTCOME; TUMOR SUPPRESSOR GENE;

AMINO ACIDS; BASE PAIR MISMATCH; BINDING SITES; CARCINOGENS; CATIONS, DIVALENT; DEOXYADENINE NUCLEOTIDES; DNA ADDUCTS; DNA-DIRECTED DNA POLYMERASE; FOOD; HYDROGEN BONDING; MAGNESIUM; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY;

EUKARYOTA; MAMMALIA;

EID: 25444458311     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx050132b     Document Type: Article

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