The Effect of DNA Structure on the Catalytic Efficiency and Fidelity of Human DNA Polymerase β on Templates with Platinum-DNA Adducts

Journal of Biological Chemistry

Volumn 276, Issue 22, 2001, Pages 18999-19005

  Vaisman, Alexandra ^a   Warren, Matthew W ^b   Chaney, Stephen G ^b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; COMPLEXATION; CRYSTAL STRUCTURE; DNA; DRUG PRODUCTS; ENZYME KINETICS; TUMORS;

LIGANDS;

BIOCHEMISTRY;

CISPLATIN; DNA; DNA DIRECTED DNA POLYMERASE BETA; LIGAND; OXALIPLATIN; PLATINUM; 2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE PHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DNA BINDING PROTEIN; PLATINUM COMPLEX; RECOMBINANT PROTEIN;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DNA ADDUCT; DNA BINDING; DNA CONFORMATION; DNA REPLICATION; DNA SEQUENCE; DNA STRUCTURE; DNA TEMPLATE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN DNA BINDING; BINDING SITE; CATALYSIS; CHEMICAL MODEL; CHEMISTRY; CONFORMATION; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN CONFORMATION;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BINDING SITES; CATALYSIS; DEOXYCYTOSINE NUCLEOTIDES; DNA; DNA ADDUCTS; DNA POLYMERASE BETA; DNA-BINDING PROTEINS; HUMANS; KINETICS; LIGANDS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; ORGANOPLATINUM COMPOUNDS; PLATINUM; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 0035378482     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007805200     Document Type: Article

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