Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 46, 2004, Pages 16186-16191

  Dutta, Shuchismita ^a,c   Li, Ying ^a   Johnson, Donald ^a   Dzantiev, Leonid ^b,d   Richardson, Charles C ^a   Romano, Louis J ^b   Ellenberger, Tom ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 FLUORENYLAMINE; DNA POLYMERASE; N (2 FLUORENYL)ACETAMIDE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIOPHAGE T7; CRYSTAL STRUCTURE; DNA ADDUCT; DNA REPLICATION; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; FRAMESHIFT MUTATION; HYDROPHOBICITY; MUTAGENESIS; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

2-ACETYLAMINOFLUORENE; BASE SEQUENCE; CARCINOGENS; CRYSTALLOGRAPHY, X-RAY; DNA; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; FLUORENES; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTAGENESIS;

EID: 9244229513     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0406516101     Document Type: Article

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