The role of DNA adducts in chemical carcinogenesis

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 402, Issue 1-2, 1998, Pages 67-75

  Garner, R Colin ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Accelerator mass spectrometry; Biomarker; Cancer; DNA adduct; Molecular epidemiology

Indexed keywords

CANCER; CHEMICAL CARCINOGENESIS; CONFERENCE PAPER; DNA ADDUCT; DNA REPAIR; DNA SEQUENCE; DROSOPHILA; DRUG DNA INTERACTION; FOOD INTAKE; GENOTOXICITY; HUMAN; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CARCINOGENS; DNA; DNA ADDUCTS; HUMANS; MICE; MUTAGENS;

EID: 0032543359     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00283-2     Document Type: Conference Paper

References (78)

1. [1] R. Doll, Nature and nurture: possibilities for cancer control, Carcinogenesis 17 (1996) 177-184.
2. [2] R. Doll, R. Peto, K. Wheatley, R. Gray, I. Sutherland, Mortality in relation to smoking: 40 years' observations on male British doctors, BMJ 309 (1994) 901-911.
3. [3] V.A. Bohr, DNA repair fine structure and its relation to genomic instability, Carcinogenesis 16 (1995) 2885-2892.
4. [4] H.J. Müller, Artificial transmutation of the gene, Science 66 (1928) 84-87.
5. [5] C. Auerbach, J.M. Robson, J.G. Carr, The chemical production of mutations, Science 105 (1947) 243-247.
6. [6] P. Brookes, P.D. Lawley, Evidence for the binding of polynuclear aromatic hydrocarbons to the nucleic acid of mouse skin: relation between carcinogenic potency of hydrocarbons and their binding to DNA, Nature 202 (1964) 781-784.
7. [7] J.A. Miller, Carcinogenesis by chemicals: an overview -G.H.A. Clowes Memorial Lecture, Cancer Res. 30 (1970) 559-576.
8. 1 to DNA, RNA, polyribonucleotides and protein in vitro, Chem. Biol. Interactions 6 (1973) 125-129.
9. [9] E. Kriek, On the mechanism of action of carcinogenic aromatic amine: II. Binding of N-hydroxy-N-acetyl-4-aminobiphenyl with guanine in rat liver nucleic acids in vivo, Chem. Biol. Interactions 3 (1971) 19-28.
10. [10] R.C. Garner, C.N. Martin, D.B. Clayson, Carcinogenic aromatic amines and related compounds, in: C.E. Searle (Ed.), Chemical Carcinogens, 2nd edn., ACS Monograph 182, American Chemical Society, Washington, 1984, pp. 175-276.
11. [11] J.R. Mehta, M. Przybylski, D.B. Ludlum, Alkylation of guanosine and deoxyguanosine by phosphoramide mustard, Cancer Res. 40 (1981) 4183-4186.
12. [12] A. Dipple, DNA adducts of chemical carcinogens, Carcinogenesis 16 (1995) 437-441.
13. [13] R.C. Garner, Genotoxicity testing, in: M. Balls, J. Bridges, Southee (Eds.), Animals and Alternatives in Toxicology, Macmillan Press, London, 1991, pp. 91-120.
14. [14] G. Talaska, A.Z.S.S. Al-Juburi, F.F. Kadlubar, Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct, PNAS 88 (1991) 5350-5354.
15. [15] D. Lin, J.O. Lay, M.S. Bryant, C. Malaveille, M. Friesen, H. Bartsch, N.P. Lang, F.F. Kadlubar, Analysis of 4-aminobiphenyl-DNA adducts in human urinary bladder and lung by alkaline hydrolysis and negative ion gas chromatography-mass spectrometry, Environ. Health Perspect. 102 (1994) 11-16.
16. 32P-postlabelling, Cancer Epidemiol. Biomarkers Prev. 2 (1993) 63-69.
17. 6-methylguanine in DNA from human tissues, Carcinogenesis 13 (1992) 469-475.
18. 4-ethylthymine in human liver and peripheral blood leukocyte DNA, Carcinogenesis 16 (1995) 1277-1280.
19. [19] J.D. Groopman, P.R. Donahue, J. Zhu, J. Chen, G.N. Wogan, Aflatoxin metabolism in humans: detection of aflatoxin metabolites and nucleic acid adducts in urine by affinity chromatography, PNAS 82 (1985) 6492-6497.
20. [20] J.C. Harrison, R.C. Garner, Immunological and HPLC detection of aflatoxin adducts in human tissues after an acute poisoning incident in SE Asia, Carcinogenesis 12 (1991) 741-743.
21. 1 DNA adducts in smeared tumor tissue from patients with hepatocellular carcinoma, Hepatology 16 (1992) 1150-1155.
22. [22] E. Reed, R.F. Ozols, R. Tarone, S.H. Yuspa, M.C. Poirier, Platinum-DNA adducts in leukocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy, PNAS 84 (1987) 5024-5028.
23. [23] A.M.J. Fichtinger-Schepman, A.T. Van Oosterom, P.H.M. Lohman, F. Berends, cis-Diamminedichloroplatinum(II)-induced DNA adducts in peripheral leukocytes from seven cancer patients: quantitative immunochemical detection of the adduct induction and removal after a single dose of cis-diamminedichloroplatinum(II), Cancer Res. 47 (1987) 3000-3004.
24. [24] A. Weston, E.D. Bowman, Fluorescence detection of benzo(a)pyrene-DNA adducts in human lung, Carcinogenesis 12 (1991) 1445-1449.
25. [25] K. Alexandrov, M. Rojas, O. Geneste, M. Castegnaro, A.-M. Camus, S. Petruzelli, C. Giuntini, H. Bartsch, An improved fluorimetric assay for dosimetry of benzo(a)pyrene diolepoxide-DNA adducts in smokers lung: comparisons with total bulky adducts and aryl hydrocarbon-hydroxylase activity, Cancer Res. 52 (1992) 6248-6253.
26. 32P-postlabelling and ELISA, Carcinogenesis 15 (1994) 557-560.
27. [27] R.B. Everson, E. Randerath, R.M. Santella, R.C. Cefalo, T.A. Avitts, K. Randerath, Detection of smoking-related covalent DNA adducts in human placenta, Science 231 (1986) 54-57.
28. [28] D.H. Phillips, A. Hewer, C.N. Martin, R.C. Garner, M.M. King, Correlation of DNA adduct levels in human lung with cigarette smoking, Nature 336 (1988) 790-792.
29. [29] J. Cuzick, M.N. Routledge, D. Jenkins, R.C. Garner, DNA adducts in different tissues of smokers and nonsmokers, Int. J. Cancer 45 (1990) 673-678.
30. [30] D.H. Phillips, B. Schoket, A. Hewer, E. Bailey, S. Kostic, I. Vincze, Influence of cigarette smoking on the levels of DNA adducts in human bronchial epithelium and white blood cells, Int. J. Cancer 46 (1990) 569-575.
31. 32P-postlabelling: a study of the relationship with smoking history and oral contraceptive use, Carcinogenesis 15 (1994) 1097-1100.
32. 32P-postlabelling, Cancer Res. 53 (1993) 1522-1528.
33. 32P-postlabelling of aromatic DNA adducts in white blood cells from iron foundry workers, Mutation Res. 204 (1988) 531-541.
34. [34] F.P. Perera, K. Hemminki, T.-L. Young, D. Brenner, G. Kelly, R. Santella, Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers, Cancer Res. 48 (1988) 2288-2291.
35. [35] K. Hemminki, E. Grzybowska, M. Chorazy, K. Twardowska-Saucha, J.W. Sroczinsky, K.L. Putman, K. Randerath, D.H. Phillips, A. Hewer, R.M. Santella, T.L. Young, F.P. Perera, DNA adducts in humans environmentally exposed to aromatic compounds in an industrial area of Poland, Carcinogenesis 11 (1990) 1229-1231.
36. 2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo-[4,5-f]quinox-aline (dG-C8-MeIQx) in human tissues, Carcinogenesis 17 (1996) 1029-1034.
37. 32P-postlabelling, Chem. Res. Toxicol. 7 (1994) 733-739.
38. [38] H.H. Schmeiser, C.A. Bieler, M. Wiessler, C. van Ypersele de Strihou, J.-P. Cosyns, Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy, Cancer Res. 56 (1996) 2025-2028.
39. [39] A.K. Chaudhary, M. Nokubo, G.R. Reddy, S.N. Yeola, J.D. Morrow, I.A. Blair, L.A. Marnett, Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver, Science 265 (1994) 1580-1582.
40. [40] S.F. Liu, S.M. Rappaport, K. Pongracz, W.J. Bodell, Detection of styrene oxide-DNA adducts in lymphocytes of a worker exposed to styrene, in: Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention, IARC Scientific Publication No. 89, IARC, Lyon, 1988, pp. 217-222.
41. 32P-postlabelling, Carcinogenesis 16 (1995) 613-617.
42. [42] B. Singer, J.M. Essigmann, Site-specific mutagenesis: retrospective and prospective, Carcinogenesis 12 (1991) 949-955.
43. [43] E.L. Loechler, The role of adduct site-specific mutagenesis in understanding how carcinogen-DNA adducts cause mutations: perspectives, prospects and problems, Carcinogenesis 17 (1996) 895-902.
44. [44] M.S. Greenblatt, W.P. Bennett, M. Hollstein, C.C. Harris, Mutations in the p53 tumour suppressor gene: clues to cancer etiology and molecular pathogenesis, Cancer Res. 54 (1994) 4855-4878.
45. [45] B. Ruggeri, M. DiRado, S.Y. Zhang, B. Bauer, T. Goodrow, A.J.P. Klein-Szanto, Benzo(a)pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene, PNAS 90 (1991) 1013-1017.
46. [46] A.K. Basu, J.M. Essigmann, Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents, Chem. Res. Toxicol. 1 (1988) 1-18.
47. [47] P.T. Strickland, M.N. Routledge, A. Dipple, Methodologies for measuring carcinogen adducts in humans, Cancer Epidemiol. Biomarkers Prev. 2 (1993) 607-619.
48. [48] P.B. Farmer, Carcinogen adducts: use in diagnosis and risk assessment, Clin. Chem. 40 (1994) 1438-1443.
49. [49] J.S. Vogel, K.W. Turteltaub, R. Finkel, D.E. Nelson, Accelerator mass spectrometry - isotope quantification at attomole sensitivity, Anal. Chem. 67 (1995) 353A-359A.
50. [50] C.E. Frantz, C. Bangerter, E. Fultz, K.M. Mayer, J.S. Vogel, K.W. Turteltaub, Dose-response studies of MeIQx in rat liver and liver DNA at low doses, Carcinogenesis 16 (1995) 367-373.
51. 32P-Labelling test for DNA damage, PNAS 78 (1981) 6126-6129.
52. [52] W.P. Watson, Post-radiolabelling for detecting DNA damage, Mutagenesis 2 (1987) 319-331.
53. 32P-postlabelling assay, Carcinogenesis 13 (1992) 1053-1074.
54. [54] C.M. Dale, R.C. Garner, Measurement of DNA adducts in humans after complex mixture exposure, Food Chem. Toxicol. 34 (1996) 905-919.
55. [55] C.C. Harris, K. Vahakangas, M.J. Newman, G.E. Trivers, A. Shamsuddin, N. Sinopoli, D.L. Mann, W.E. Wright, Detection of benzo(a)pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers, PNAS 82 (1985) 6672-6676.
56. [56] R.W. Giese, Ananlysis of DNA adducts by mass spectrometry, in: R.C. Garner, P.B. Farmer, G.T. Steele, A.S. Wright (Eds.), Human Carcinogen Exposure: Biomonitoring and Risk Assessment, IRL Press, Oxford, 1991, pp. 247-253.
57. [57] D. Arnott, J. Shabanowitz, D.F. Hunt, Mass spectrometry of proteins and peptides: sensitive and accurate mass measurement and sequence analysis, Clin. Chem. 39 (1993) 2005-2010.
58. [58] M.C. Poirier, S.H. Yuspa, I.B. Weinstein, S. Blobstein, Detection of carcinogen-DNA adducts by radioimmunoassay, Nature 270 (1977) 186-188.
59. 6-methylguanine in mouse liver satellite and main-band DNA following dimethylnitrosamine administration, J. Cancer Res. Clin. Oncol. 98 (1980) 127-138.
60. 6-ethyldeoxyguanosine in DNA exposed to N-ethyl-N-nitrosourea, Cancer Res. 40 (1980) 887-896.
61. [61] P.T. Strickland, J.M. Boyle, Characterisation of two monoclonal antibodies specific for dimerised and non-dimerised adjacent thymidines in single stranded DNA, Photochem. Photobiol. 34 (1981) 595-601.
62. [62] M.C. Poirier, S.J. Lippard, L.A. Zwelling, H.M. Ushay, D. Kerrigan, C.C. Thill, R.M. Santella, D. Grunberger, S.H. Yuspa, Antibodies elicited against cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro, PNAS 79 (1982) 6443-6447.
63. [63] A.C.M. Plooy, A.M.J. Fichtinger-Schepman, H.H. Schutte, M. van Dijk, P.H.M. Lohman, The quantitative detection of various Pt-DNA adducts in Chinese hamster ovary cells treated with cisplatin: application of immunological techniques, Carcinogenesis 6 (1985) 561-566.
64. [64] P.J. Hertzog, A. Shaw, J.R. Lindsay Smith, R.C. Garner, Improved conditions for the production of monoclonal antibodies to carcinogen-modified DNA, for use in enzyme-linked immuno-sorbent assays (ELISA), J. Immunol. Meth. 62 (1983) 49-58.
65. [65] J.D. Groopman, L.J. Trudel, P.R. Donahue, A. Marshak-Rothstein, G.N. Wogan, High affinity monoclonal antibodies for aflatoxins and their application to solid phase immunoassay, PNAS 81 (1984) 7728-7731.
66. [66] M.C. Poirier, R. Santella, I.B. Weinstein, D. Grunberger, S.H. Yuspa, Quantitation of benzo(a)pyrene-deoxyguanosine adducts by radioimmunoassay, Cancer Res. 40 (1980) 412-416.
67. [67] F.P. Perera, M.C. Poirier, S.H. Yuspa, J. Nakayama, A. Jaretzki, M.M. Curnen, D.M. Knowles, I.B. Weinstein, A pilot project in molecular cancer epidemiology: determination of benzo(a)pyrene-DNA adducts in animal and human tissues by immunoassays, Carcinogenesis 3 (1982) 1405-1410.
68. 32P-postlabelling: immunofluorescence analysis of benzo(a)-pyrene-DNA adducts in bronchial cells from smokers, in: H. Bartsch, K. Hemminki, I.K. O'Neill (Eds.), Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention, IARC, Lyon, France, 1988, pp. 146-156.
69. 7-ethylguanine in purified DNA and in cells in situ. Crossreaction with methyl, 2-hydroxyethyl and sulphur mustard adducts, Carcinogenesis 12 (1991) 1041-1049.
70. [70] J.D. Groopman, P.L. Skipper, P.R. Donahue, L.J. Trudel, M. Wildschutte, F.F. Kadlubar, S.R. Tannenbaum, Monoclonal antibodies and rabbit antisera recognizing 4-aminobiphenyl-DNA adducts and application to immunoaffinity chromatography, Carcinogenesis 13 (1992) 917-922.
71. [71] M.J. Tilby, J.M. Styles, C.J. Denn, Immunological detection of DNA damage caused by melphalan using monoclonal antibodies, Cancer Res. 47 (1987) 1542-1546.
72. [72] P. Degan, R. Montesano, C.P. Wild, Antibodies against 7-methydeoxyguanosine: its detection in rat peripheral blood lymphocyte DNA and potential applications to molecular epidemiology, Cancer Res. 48 (1988) 5065-5070.
73. [73] X.Y. Yang, V. deLeo, R.M. Santella, Immunological detection and visualisation of 8-methoxypsoralen-DNA photoadducts, Cancer Res. 47 (1987) 2451-2455.
74. [74] B. Tierney, A. Benson, R.C. Garner, Immunoaffinity chromatography of carcinogen DNA adducts with polyclonal antibodies directed against benzo(a)pyrene diol-epoxide-DNA, JNCI 77 (1986) 261-267.
75. 6-alkylguanine-DNA alkyltransferase, Carcinogenesis 10 (1989) 661-666.
76. 6-methylguanine in human blood leucocyte DNA during exposure to procarbazine and its relationships with dose and repair, Cancer Res. 50 (1990) 2759-2764.
77. [77] J.M. Allan, R.C. Garner, The use of purified DNA repair proteins to detect DNA damage, Mutation Res. 313 (1994) 165-174.
78. [78] G.P. Pfeifer, R. Drouin, G.P. Holmquist, Detection of DNA adducts at the DNA sequence level by ligation-mediated PCR, Mutation Res. 288 (1993) 39-46.