All three SOS-inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis

EMBO Journal

Volumn 19, Issue 22, 2000, Pages 6259-6265

  Napolitano, R ^a   Janel Bintz, R ^a   Wagner, J ^a   Fuchs, R P P ^a  

^a IRCAD   (France)

Author keywords

Chemical carcinogens; DNA polymerases; Frameshift mutagenesis; NarI mutation hot spot; Slippage mutagenesis

Indexed keywords

BENZO[A]PYRENE; CARCINOGEN; DNA DIRECTED DNA POLYMERASE ALPHA; DNA POLYMERASE;

ARTICLE; DNA ADDUCT; DNA DAMAGE; ESCHERICHIA COLI; FRAMESHIFT MUTATION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL;

2-ACETYLAMINOFLUORENE; BASE SEQUENCE; BENZO(A)PYRENE; DNA DAMAGE; DNA POLYMERASE BETA; DNA POLYMERASE II; DNA REPLICATION; DNA, BACTERIAL; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FRAMESHIFT MUTATION; MUTAGENESIS; SOS RESPONSE (GENETICS);

ESCHERICHIA COLI;

EID: 0034669125     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.22.6259     Document Type: Article

References (52)

1. The mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA and SSB and specialized for translesion replication
2. SOS mutagenesis results from up-regulation of translesion synthesis
3. DNA polymerase II (polB) is involved in a new DNA repair pathway for DNA interstrand cross-links in Escherichia coli
4. Purification and characterization of an inducible Escherichia coli DNA polymerase capable of insertion and bypass at abasic lesions in DNA
5. Sequence-dependent modulation of frameshift mutagenesis at NarI-derived mutation hot spots
6. Role of RecA protein in untargeted UV mutagenesis of bacteriophage λ: Evidence for the requirement of the dinB gene
7. Single adduct mutagenesis: Strong effect of the position of a single acetyl-aminofluorene adduct within a mutation hot spot
8. Purification and properties of wild-type and exonuclease-deficient DNA polymerase II from E.coli
9. Replication of damaged DNA: Molecular defect in xeroderma pigmentosum variant cells
10. Involvement of E.coli DNA polymerase II in response to oxidative damage and adaptive mutation
11. Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli
12. Hot spots of frameshift mutations induced by the ultimate carcinogen N-acetoxy-N-2-acetylaminofluorene
13. DNA adduct induced stabilization of slipped frameshift intermediates within repetitive sequences: Implications for mutagenesis
14. Human and mouse homologs of E.coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily
15. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Pol η
16. hRAD30 mutations in the variant form of xeroderma pigmentosum
17. Potent novel mutagens produced by broiling fish under normal conditions
18. Multiple pathways for SOS-induced mutagenesis in E.coli: An overexpression of dinB/P results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA
19. Genetic control of AAF-induced mutagenesis at alternating GC sequences: An additional role for RecA
20. Sequence determinants for -2 frameshift mutagenesis at NarI-derived hot spots
21. Carcinogen induced mutation spectrum in wild type, uvrA and umuC strains in E.coli: Strain specificity and mutation prone sequences
22. Cellular strategies for accommodating replication-hindering adducts in DNA: Control by the SOS response in E.coli
23. Carcinogen-induced frameshift mutagenesis in repetitive sequences
24. The thymine-thymine pyrimidine-pyrimidone(6-4) ultraviolet light photoproduct is highly mutagenic and specifically induces 3' thymine-to-cytosine transitions in Escherichia coli
25. Distinct genetic processing of a single benzo(a)pyrene adduct into frameshift or base substitution mutations during translesion synthesis in E.coli
26. A umuDC-independent SOS pathway for frameshift mutagenesis
27. Role of DNA polymerase II in repair replication in Escherichia coli
28. Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
29. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
30. Novel human and mouse homologs of S. Cerevisiae DNA polymerase η
31. NMR evidence of the stabilization by the carcinogen N-2-acetyl-aminofluorene of a frameshift mutation intermediate
32. NMR data show that the carcinogen N-2-acetylaminofluorene stabilizes an intermediate of -2 frameshift mutagenesis in a region of high mutation frequency
33. Carcinogenesis by chemicals: An overview
34. SOS factors involved in translesion synthesis
35. Deoxycytidyl transferase activity of yeast REV1 protein
36. Thymine-thymine dimer bypass by yeast polymerase ζ
37. Mutation enhancement by DINB1, a mammalian homologue of the E.coli mutagenesis protein DinB
38. The E.coli polB locus is identical to dinA, the structural gene for DNA polymerase II. Characterization of Pol II purified from a polB mutant
39. A phenotype for enigmatic DNA polymerase II: A pivotal role for polII in replication restart in UV-irradiated E.coli
40. Mutagenesis by the (+)-antidiolepoxide of B(a)P: What controls mutation specificity
41. Mutagenesis and more: Umudc and the E.coli SOS response
42. Substitution of mucAB or rumAB for umuDC alters the relative frequencies of two classes of mutations induced by a site-specific T-T cyclobutane dimer and the efficiency of translesion DNA synthesis
43. 2C is an error-prone DNA polymerase, E.coli polV
44. Roles of E.coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis
45. DNA polymerase II of Escherichia coli in the bypass of abasic sites in vivo
46. Greater susceptibility to mutations in lagging strand of DNA replication in Escherichia coli than in leading strand
47. The dinB gene encodes a novel E.coli DNA polymerase, DNA PolIV, involved in mutagenesis
48. The β clamp targets DNA Pol IV to DNA and strongly increases its processivity
49. Construction of a umuDC operon substitution mutation in E.coli