-
1
-
-
0032700356
-
Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides
-
AGRAWAL, S. (1999). Importance of nucleotide sequence and chemical modifications of antisense oligonucleotides. Biochem. Biophys. Acta 1489, 53-68.
-
(1999)
Biochem. Biophys. Acta
, vol.1489
, pp. 53-68
-
-
Agrawal, S.1
-
2
-
-
0028850751
-
Pharmacokinetics of antisense oligonucleotides
-
AGRAWAL, S., TEMSAMANI, J., GALBRAITH, W., and TANG, J. (1995a). Pharmacokinetics of antisense oligonucleotides. Clin. Pharmacokinet. 28, 7-16.
-
(1995)
Clin. Pharmacokinet.
, vol.28
, pp. 7-16
-
-
Agrawal, S.1
Temsamani, J.2
Galbraith, W.3
Tang, J.4
-
3
-
-
0000397940
-
Pharmacokinetics and bioavailability of oligonucleotides following oral and colorectal administration in experimental animals
-
S.T. Crooke, ed. (Springer, Berlin)
-
AGRAWAL, S., and ZHANG, R. (1998). Pharmacokinetics and bioavailability of oligonucleotides following oral and colorectal administration in experimental animals. In: Antisense Research and Application: Handbook of Experimental Pharmacology. S.T. Crooke, ed. (Springer, Berlin), pp. 525-543.
-
(1998)
Antisense Research and Application: Handbook of Experimental Pharmacology
, pp. 525-543
-
-
Agrawal, S.1
Zhang, R.2
-
4
-
-
0029100397
-
Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration
-
AGRAWAL, S., ZHANG, X., LU, Z., ZHAO, H., TAMBURIN, J.M., YAN, J., CAI, H., DIASIO, R.B., HABUS, I., JIANG, Z., et al. (1995b). Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration. Biochem. Pharmacol. 50, 571-576.
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 571-576
-
-
Agrawal, S.1
Zhang, X.2
Lu, Z.3
Zhao, H.4
Tamburin, J.M.5
Yan, J.6
Cai, H.7
Diasio, R.B.8
Habus, I.9
Jiang, Z.10
-
5
-
-
0035061661
-
Absorption, distribution, metabolism, and excretion of a respirable antisense oligonucleotide for asthma
-
ALI, S., LEONARD, S.A., KUKOLY, C.A., METZGER, W.J., WOOLES, W.R., McGINTY, J.F., TANAKA, M., SANDRA-SAGRA, A., and NYCE, J.W. (2001). Absorption, distribution, metabolism, and excretion of a respirable antisense oligonucleotide for asthma. Am. J. Respir. Crit. Care Med. 163, 989-993.
-
(2001)
Am. J. Respir. Crit. Care Med.
, vol.163
, pp. 989-993
-
-
Ali, S.1
Leonard, S.A.2
Kukoly, C.A.3
Metzger, W.J.4
Wooles, W.R.5
McGinty, J.F.6
Tanaka, M.7
Sandra-Sagra, A.8
Nyce, J.W.9
-
6
-
-
0034775320
-
Potential tumor-targeting peptide vector of histidylated oligolysine conjugated to a tumor-homing RGD motif
-
AOKI, Y., HOSAKA, S., KAWA, S., and KIYOSAWA, K. (2001). Potential tumor-targeting peptide vector of histidylated oligolysine conjugated to a tumor-homing RGD motif. Cancer Gene Ther. 8, 783-787.
-
(2001)
Cancer Gene Ther.
, vol.8
, pp. 783-787
-
-
Aoki, Y.1
Hosaka, S.2
Kawa, S.3
Kiyosawa, K.4
-
7
-
-
0032535999
-
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
-
ARAP, W., PASQUALINI, R., and RUOSLAHTI, E. (1998). Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279, 377-380.
-
(1998)
Science
, vol.279
, pp. 377-380
-
-
Arap, W.1
Pasqualini, R.2
Ruoslahti, E.3
-
8
-
-
0020021127
-
Carbohydrate-specific receptors of the liver
-
ASHWELL, G., and HARFORD, J. (1982). Carbohydrate-specific receptors of the liver. Annu. Rev. Biochem. 51, 531-554.
-
(1982)
Annu. Rev. Biochem.
, vol.51
, pp. 531-554
-
-
Ashwell, G.1
Harford, J.2
-
9
-
-
0031930787
-
Integrin receptor-targeted transfer peptides for efficient delivery of antisense oligodeoxynucleotides
-
BACHMANN, A.S., SUROVOY, A., JUNG, G., and MOELLING, K. (1998). Integrin receptor-targeted transfer peptides for efficient delivery of antisense oligodeoxynucleotides. J. Mol. Med. 76, 126-132.
-
(1998)
J. Mol. Med.
, vol.76
, pp. 126-132
-
-
Bachmann, A.S.1
Surovoy, A.2
Jung, G.3
Moelling, K.4
-
10
-
-
0029461123
-
Targeted delivery of antisense DNA in woodchuck hepatitis virus-infected woodchucks
-
BARTHOLOMEW, R.M., CARMICHAEL, E.P., FINDEIS, M.A., WU, C.H., and WU, G.Y. (1995). Targeted delivery of antisense DNA in woodchuck hepatitis virus-infected woodchucks. J. Viral Hepat. 2, 273-278.
-
(1995)
J. Viral Hepat.
, vol.2
, pp. 273-278
-
-
Bartholomew, R.M.1
Carmichael, E.P.2
Findeis, M.A.3
Wu, C.H.4
Wu, G.Y.5
-
11
-
-
0028845327
-
Binding of phosphorothioate oligodeoxynucleotides to basic fibroblast growth factor, recombinant soluble CD4, laminin and fibronectin is P-chirality independent
-
BENIMETSKAYA, L., TONKINSON, J.L., KOZIOLKIEWICZ, M., KARWOWSKI, B., GUGA, P., ZELTSER, R., STEC, W., and STEIN, C.A. (1995). Binding of phosphorothioate oligodeoxynucleotides to basic fibroblast growth factor, recombinant soluble CD4, laminin and fibronectin is P-chirality independent. Nucleic Acids Res. 23, 4239-4245.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 4239-4245
-
-
Benimetskaya, L.1
Tonkinson, J.L.2
Koziolkiewicz, M.3
Karwowski, B.4
Guga, P.5
Zeltser, R.6
Stec, W.7
Stein, C.A.8
-
12
-
-
0022338699
-
DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA
-
BENNETT, R.M., GABOR, G.T., and MERRITT, M.M. (1985). DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA. J. Clin. Invest. 76, 2182-2190.
-
(1985)
J. Clin. Invest.
, vol.76
, pp. 2182-2190
-
-
Bennett, R.M.1
Gabor, G.T.2
Merritt, M.M.3
-
13
-
-
0037133088
-
Optimization of factors influencing the transfection efficiency of folate-PEG-folate-graft-polyethylenimine
-
BENNS, J.M., MAHATO, R.I., and KIM, S.W. (2002). Optimization of factors influencing the transfection efficiency of folate-PEG-folate-graft-polyethylenimine. J. Control Release 79, 255-269.
-
(2002)
J. Control Release
, vol.79
, pp. 255-269
-
-
Benns, J.M.1
Mahato, R.I.2
Kim, S.W.3
-
14
-
-
0034910912
-
Folate-PEG-folate-graft-polyethylenimine-based gene delivery
-
BENNS, J.M., MAHESHWARI, A., FURGESON, D.Y., MAHATO, R.I., and KIM, S.W. (2001). Folate-PEG-folate-graft-polyethylenimine-based gene delivery. J. Drug Target 9, 123-139.
-
(2001)
J. Drug Target
, vol.9
, pp. 123-139
-
-
Benns, J.M.1
Maheshwari, A.2
Furgeson, D.Y.3
Mahato, R.I.4
Kim, S.W.5
-
15
-
-
0036009641
-
Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes
-
BIESSEN, E.A., SLIEDREGT-BOL, K., PA, T.H., PRINCE, P., VAN DER BILT, E., VALENTIJN, A.R., MEEUWENOORD, N.J., PRINCEN, H., BIJSTERBOSCH, M.K., VAN DER MAREL, G.A., VAN BOOM, J.H., and VAN BERKEL, T.J. (2002). Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes. Bioconjug. Chem. 13, 295-302.
-
(2002)
Bioconjug. Chem.
, vol.13
, pp. 295-302
-
-
Biessen, E.A.1
Sliedregt-Bol, K.2
Pa, T.H.3
Prince, P.4
Van Der Bilt, E.5
Valentijn, A.R.6
Meeuwenoord, N.J.7
Princen, H.8
Bijsterbosch, M.K.9
Van Der Marel, G.A.10
Van Boom, J.H.11
Van Berkel, T.J.12
-
16
-
-
0033564268
-
Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo
-
BIESSEN, E.A., VIETSCH, H., RUMP, E.T., FLUITER, K., KUIPER, J., BIJSTERBOSCH, M.K., and VAN BERKEL, T.J. (1999). Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo. Biochem. J. 340, 783-792.
-
(1999)
Biochem. J.
, vol.340
, pp. 783-792
-
-
Biessen, E.A.1
Vietsch, H.2
Rump, E.T.3
Fluiter, K.4
Kuiper, J.5
Bijsterbosch, M.K.6
Van Berkel, T.J.7
-
17
-
-
0030751852
-
In vivo fate of phosphorothioate antisense oligodeoxynucleotides: Predominant uptake by scavenger receptors on endothelial liver cells
-
BIJSTERBOSCH, M.K., MANOHARAN, M., RUMP, E.T., DE VRUEH, R.L., VAN VEGHEL, R., TIVEL, K.L., BIESSEN, E.A., BENNETT, C.F., COOK, P.D., and VAN BERKEL, T.J. (1997). In vivo fate of phosphorothioate antisense oligodeoxynucleotides: Predominant uptake by scavenger receptors on endothelial liver cells. Nucleic Acids Res. 25, 3290-3296.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 3290-3296
-
-
Bijsterbosch, M.K.1
Manoharan, M.2
Rump, E.T.3
De Vrueh, R.L.4
Van Veghel, R.5
Tivel, K.L.6
Biessen, E.A.7
Bennett, C.F.8
Cook, P.D.9
Van Berkel, T.J.10
-
18
-
-
0035093387
-
Transdermal delivery of antisense oligonucleotides can induce changes in gene expression in vivo
-
BRAND, R.M., HANNAH, T.L., NORRIS, J., and IVERSEN, P.L. (2001). Transdermal delivery of antisense oligonucleotides can induce changes in gene expression in vivo. Antisense Nucleic Acid Drug Dev. 11, 1-6.
-
(2001)
Antisense Nucleic Acid Drug Dev.
, vol.11
, pp. 1-6
-
-
Brand, R.M.1
Hannah, T.L.2
Norris, J.3
Iversen, P.L.4
-
19
-
-
0034739603
-
Transdermal delivery of antisense compounds
-
BRAND, R.M., and IVERSEN, P.L. (2000). Transdermal delivery of antisense compounds. Adv. Drug Deliv. Rev. 44, 51-57.
-
(2000)
Adv. Drug Deliv. Rev.
, vol.44
, pp. 51-57
-
-
Brand, R.M.1
Iversen, P.L.2
-
20
-
-
0028114548
-
Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding
-
BROWN, D.A., KANG, S.H., GRYAZNOV, S.M., DEDIONISIO, L., HEIDENREICH, O., SULLIVAN, S., XU, X., and NERENBERG, M.I. (1994). Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding. J. Biol. Chem. 269, 26801-26805.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 26801-26805
-
-
Brown, D.A.1
Kang, S.H.2
Gryaznov, S.M.3
Dedionisio, L.4
Heidenreich, O.5
Sullivan, S.6
Xu, X.7
Nerenberg, M.I.8
-
21
-
-
0033984862
-
Phosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice
-
BUTLER, M., CROOKE, R.M., GRAHAM, M.J., LEMONIDIS, K.M., LOUGHEED, M., MURRAY, S.F., WITCHELL, D., STEINBRECHER, U., and BENNETT, C.F. (2000). Phosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice. J. Pharmacol. Exp. Ther. 292, 489-496.
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.292
, pp. 489-496
-
-
Butler, M.1
Crooke, R.M.2
Graham, M.J.3
Lemonidis, K.M.4
Lougheed, M.5
Murray, S.F.6
Witchell, D.7
Steinbrecher, U.8
Bennett, C.F.9
-
22
-
-
0030669520
-
Cellular distribution of phosphorothioate oligodeoxynucleotides in normal rodent tissues
-
BUTLER, M., STECKER, K., and BENNETT, C.F. (1997). Cellular distribution of phosphorothioate oligodeoxynucleotides in normal rodent tissues. Lab. Invest. 77, 379-388.
-
(1997)
Lab. Invest.
, vol.77
, pp. 379-388
-
-
Butler, M.1
Stecker, K.2
Bennett, C.F.3
-
23
-
-
85053302756
-
Targeted delivery of anti-hepatitis B oligonucleotides
-
S. Akhtar, ed. (CRC Press, New York)
-
CARMICHAEL, E., CHIOU, H., FINDEIS, M., SPITALNY, G., and MERWIN, J. (1995). Targeted delivery of anti-hepatitis B oligonucleotides. In: Delivery Strategies for Antisense Oligonucleotide Therapeutics. S. Akhtar, ed. (CRC Press, New York), pp. 267-282.
-
(1995)
Delivery Strategies for Antisense Oligonucleotide Therapeutics
, pp. 267-282
-
-
Carmichael, E.1
Chiou, H.2
Findeis, M.3
Spitalny, G.4
Merwin, J.5
-
24
-
-
0028220371
-
Inhibition of leukaemia cell proliferation by folic acid-polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into HL-60 cells
-
CITRO, G., SZCZYLIK, C., GINOBBI, P., ZUPI, G., and CALABRETTA, B. (1994). Inhibition of leukaemia cell proliferation by folic acid-polylysine-mediated introduction of c-myb antisense oligodeoxynucleotides into HL-60 cells. Br. J. Cancer 69, 463-467.
-
(1994)
Br. J. Cancer
, vol.69
, pp. 463-467
-
-
Citro, G.1
Szczylik, C.2
Ginobbi, P.3
Zupi, G.4
Calabretta, B.5
-
25
-
-
7844249025
-
Liposomes enhance delivery and expression of an RGD-oligolysine gene transfer vector in human tracheal cells
-
COLIN, M., HARBOTTLE, R.P., KNIGHT, A., KORNPROBST, M., COOPER, R.G., MILLER, A.D., TRUGNAN, G., CAPEAU, J., COUTELLE, C., and BRAHIMI-HORN, M.C. (1998). Liposomes enhance delivery and expression of an RGD-oligolysine gene transfer vector in human tracheal cells. Gene Ther. 5, 1488-1498.
-
(1998)
Gene Ther.
, vol.5
, pp. 1488-1498
-
-
Colin, M.1
Harbottle, R.P.2
Knight, A.3
Kornprobst, M.4
Cooper, R.G.5
Miller, A.D.6
Trugnan, G.7
Capeau, J.8
Coutelle, C.9
Brahimi-Horn, M.C.10
-
26
-
-
0037575526
-
Medicinal chemistry of antisense oligonucleotides
-
S.T. Crooke, ed. (Marcel Dekker, New York)
-
COOK, P.D. (2001). Medicinal chemistry of antisense oligonucleotides. In: Antisense Drug Technology: Principles, strategies and applications. S.T. Crooke, ed. (Marcel Dekker, New York), pp. 29-55.
-
(2001)
Antisense Drug Technology: Principles, Strategies and Applications
, pp. 29-55
-
-
Cook, P.D.1
-
27
-
-
0027786912
-
14C-labeled phosphorothioate oligonucleotide ISIS 2105 after in travenous administration to rats
-
14C-labeled phosphorothioate oligonucleotide ISIS 2105 after in travenous administration to rats. J. Pharmacol. Exp. Ther. 267, 1181-1190.
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.267
, pp. 1181-1190
-
-
Cossum, P.A.1
Sasmor, H.2
Dellinger, D.3
Truong, L.4
Cummins, L.5
Owens, S.R.6
Markham, P.M.7
Shea, J.P.8
Crooke, S.9
-
28
-
-
0028183175
-
14C-labeled phosphorothioate oligonucleotide, ISIS 2105, after intradermal administration to rats
-
14C-labeled phosphorothioate oligonucleotide, ISIS 2105, after intradermal administration to rats. J. Pharmacol. Exp. Ther. 269, 89-94.
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.269
, pp. 89-94
-
-
Cossum, P.A.1
Truong, L.2
Owens, S.R.3
Markham, P.M.4
Shea, J.P.5
Crooke, S.T.6
-
29
-
-
0042108869
-
Suborgan pharmacokinetics
-
S.T. Crooke, ed. (Marcel Dekker, New York)
-
CROOKE, R.M., and GRAHAM, M.J. (2001). Suborgan pharmacokinetics. In: Antisense Drug Technology: Principles, Strategies and Applications. S.T. Crooke, ed. (Marcel Dekker, New York), pp. 155-182.
-
(2001)
Antisense Drug Technology: Principles, Strategies and Applications
, pp. 155-182
-
-
Crooke, R.M.1
Graham, M.J.2
-
30
-
-
0028856820
-
In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides
-
CROOKE, R.M., GRAHAM, M.J., COOKE, M.E., and CROOKE, S.T. (1995). In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides. J. Pharmacol. Exp. Ther. 275, 462-473.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.275
, pp. 462-473
-
-
Crooke, R.M.1
Graham, M.J.2
Cooke, M.E.3
Crooke, S.T.4
-
31
-
-
0033981544
-
Metabolism of antisense oligonucleotides in rat liver homogenates
-
CROOKE, R.M., GRAHAM, M.J., MARTIN, M.J., LEMONIDIS, K.M., WYRZYKIEWIECZ, T., and CUMMINS, L.L. (2000). Metabolism of antisense oligonucleotides in rat liver homogenates. J. Pharmcol. Exp. Ther. 292, 140-149.
-
(2000)
J. Pharmcol. Exp. Ther.
, vol.292
, pp. 140-149
-
-
Crooke, R.M.1
Graham, M.J.2
Martin, M.J.3
Lemonidis, K.M.4
Wyrzykiewiecz, T.5
Cummins, L.L.6
-
32
-
-
0034722899
-
Potential roles of antisense technology in cancer chemotherapy
-
CROOKE, S.T. (2000). Potential roles of antisense technology in cancer chemotherapy. Oncogene 19, 6651-6659.
-
(2000)
Oncogene
, vol.19
, pp. 6651-6659
-
-
Crooke, S.T.1
-
33
-
-
12644302203
-
Pharmacokinetic properties of several novel oligonucleotide analogs in mice
-
CROOKE, S.T., GRAHAM, M.J., ZUCKERMAN, J.E., BROOKS, D., CONKLIN, B.S., CUMMINS, L.L., GREIG, M.J., GUINOSSO, C.J., KORNBRUST, D., MANOHARAN, M., SASMOR, H.M., SCHLEICH, T., TIVEL, K.L., and GRIFFEY, R.H. (1996). Pharmacokinetic properties of several novel oligonucleotide analogs in mice. J. Pharmacol. Exp. Ther. 277, 923-937.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.277
, pp. 923-937
-
-
Crooke, S.T.1
Graham, M.J.2
Zuckerman, J.E.3
Brooks, D.4
Conklin, B.S.5
Cummins, L.L.6
Greig, M.J.7
Guinosso, C.J.8
Kornbrust, D.9
Manoharan, M.10
Sasmor, H.M.11
Schleich, T.12
Tivel, K.L.13
Griffey, R.H.14
-
34
-
-
0030839546
-
Identification and characterization of second-generation antisense oligonucleotides
-
DEAN, N.M., and GRIFFEY, R.H. (1997). Identification and characterization of second-generation antisense oligonucleotides. Antisense Nucleic Acid Drug Dev. 7, 229-233.
-
(1997)
Antisense Nucleic Acid Drug Dev.
, vol.7
, pp. 229-233
-
-
Dean, N.M.1
Griffey, R.H.2
-
35
-
-
0033943076
-
Role of alpha v integrins during angiogenesis
-
ELICEIRI, B.P., and CHERESH, D.A. (2000). Role of alpha v integrins during angiogenesis. Cancer J. Sci. Am. 6(Suppl 3), S245-S249.
-
(2000)
Cancer J. Sci. Am.
, vol.6
, Issue.SUPPL. 3
-
-
Eliceiri, B.P.1
Cheresh, D.A.2
-
36
-
-
0032956746
-
Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway
-
ERBACHER, P., REMY, J.S., and BEHR, J.P. (1999). Gene transfer with synthetic virus-like particles via the integrin-mediated endocytosis pathway. Gene Ther. 6, 138-145.
-
(1999)
Gene Ther.
, vol.6
, pp. 138-145
-
-
Erbacher, P.1
Remy, J.S.2
Behr, J.P.3
-
37
-
-
0036843787
-
In vivo-applied functional RNAs as tools in proteomics and genomics research
-
FAMULOK, M., and VERMA, S. (2002). In vivo-applied functional RNAs as tools in proteomics and genomics research. Trends Biotechnol. 20, 462-466.
-
(2002)
Trends Biotechnol.
, vol.20
, pp. 462-466
-
-
Famulok, M.1
Verma, S.2
-
38
-
-
0035119622
-
Absolute bioavailability of 2′-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats
-
GEARY, R.S., KHATSENKO, O., BUNKER, K., CROOKE, R., MOORE, M., BURCKIN, T., TRUONG, L., SASMOR, H., and LEVIN, A.A. (2001a). Absolute bioavailability of 2′-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats. J. Pharmacol. Exp. Ther. 296(3), 898-904.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, Issue.3
, pp. 898-904
-
-
Geary, R.S.1
Khatsenko, O.2
Bunker, K.3
Crooke, R.4
Moore, M.5
Burckin, T.6
Truong, L.7
Sasmor, H.8
Levin, A.A.9
-
39
-
-
0030667690
-
Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression
-
GEARY, R.S., LEEDS, J.M., FITCHETT, J., BURCKIN, T., TRUONG, L., SPAINHOUR, C., CREEK, M., and LEVIN, A.A (1997a). Pharmacokinetics and metabolism in mice of a phosphorothioate oligonucleotide antisense inhibitor of C-raf-1 kinase expression. Drug Metab. Dispos. 25, 1272-1281.
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 1272-1281
-
-
Geary, R.S.1
Leeds, J.M.2
Fitchett, J.3
Burckin, T.4
Truong, L.5
Spainhour, C.6
Creek, M.7
Levin, A.A.8
-
40
-
-
0030797704
-
Antisense oligonucleotide inhibitors for the treatment of cancer: 1. Pharmacokinetic properties of phosphorothioate oligodeoxynucleotides
-
GEARY, R.S., LEEDS, J.M., HENRY, S.P., MONTEITH, D.K., and LEVIN, A.A. (1997b). Antisense oligonucleotide inhibitors for the treatment of cancer: 1. Pharmacokinetic properties of phosphorothioate oligodeoxynucleotides. Anticancer Drug Des. 12, 383-393.
-
(1997)
Anticancer Drug Des.
, vol.12
, pp. 383-393
-
-
Geary, R.S.1
Leeds, J.M.2
Henry, S.P.3
Monteith, D.K.4
Levin, A.A.5
-
41
-
-
0035119936
-
Pharmacokinetic properties of 2′-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats
-
GEARY, R.S., WATANABE, T.A., TRUONG, L., FREIER, S., LESNIK, E.A., SIOUFI, N.B., SASMOR, H., MANOHARAN, M., and LEVIN, A.A. (2001b). Pharmacokinetic properties of 2′-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats. J. Pharmacol. Exp. Ther. 296, 890-897.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, pp. 890-897
-
-
Geary, R.S.1
Watanabe, T.A.2
Truong, L.3
Freier, S.4
Lesnik, E.A.5
Sioufi, N.B.6
Sasmor, H.7
Manoharan, M.8
Levin, A.A.9
-
42
-
-
0035043324
-
Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides
-
GEARY, R.S., YU, R.Z., and LEVIN, A.A. (2001c). Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides. Curr. Opin. Investig. Drugs 2, 562-573.
-
(2001)
Curr. Opin. Investig. Drugs
, vol.2
, pp. 562-573
-
-
Geary, R.S.1
Yu, R.Z.2
Levin, A.A.3
-
43
-
-
0026839585
-
Analysis of oligonucleotide binding, internalization, and intracellular trafficking utilizing a novel radiolabeled crosslinker
-
GESELOWITZ, D.A., and NECKERS, L.M. (1992). Analysis of oligonucleotide binding, internalization, and intracellular trafficking utilizing a novel radiolabeled crosslinker. Antisense Res. Dev. 2, 17-25.
-
(1992)
Antisense Res. Dev.
, vol.2
, pp. 17-25
-
-
Geselowitz, D.A.1
Neckers, L.M.2
-
45
-
-
0031044157
-
Folic acid-polylysine carrier improves efficacy of c-myc antisense oligodeoxynucleotides on human melanoma (M14) cells
-
GINOBBI, P., GEISER, T.A., OMBRES, D., and CITRO, G. (1997). Folic acid-polylysine carrier improves efficacy of c-myc antisense oligodeoxynucleotides on human melanoma (M14) cells. Anticancer Res. 17, 29-35.
-
(1997)
Anticancer Res.
, vol.17
, pp. 29-35
-
-
Ginobbi, P.1
Geiser, T.A.2
Ombres, D.3
Citro, G.4
-
46
-
-
0030987678
-
Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302)
-
GLOVER, J.M., LEEDS, J.M., MANT, T.G., AMIN, D., KISNER, D.L., ZUCKERMAN, J.E., GEARY, R.S., LEVIN, A.A., and SHANAHAN, W.R., JR. (1997). Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302). J. Pharmacol. Exp. Ther. 282, 1173-1180.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.282
, pp. 1173-1180
-
-
Glover, J.M.1
Leeds, J.M.2
Mant, T.G.3
Amin, D.4
Kisner, D.L.5
Zuckerman, J.E.6
Geary, R.S.7
Levin, A.A.8
Shanahan W.R., Jr.9
-
47
-
-
0035427644
-
Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration
-
GRAHAM, M.J., CROOKE, S.T., LEMONIDIS, K.M., GAUS, H.J., TEMPLIN, M.V., and CROOKE, R.M. (2001). Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration. Biochem. Pharmacol. 62, 297-306.
-
(2001)
Biochem. Pharmacol.
, vol.62
, pp. 297-306
-
-
Graham, M.J.1
Crooke, S.T.2
Lemonidis, K.M.3
Gaus, H.J.4
Templin, M.V.5
Crooke, R.M.6
-
48
-
-
0031821074
-
In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration
-
GRAHAM, M.J., CROOKE, S.T., MONTEITH, D.K., COOPER, S.R., LEMONIDIS, K.M., STECKER, K.K., MARTIN, M.J., and CROOKE, R.M. (1998). In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration. J. Pharmacol. Exp. Ther. 286(1), 447-458.
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.286
, Issue.1
, pp. 447-458
-
-
Graham, M.J.1
Crooke, S.T.2
Monteith, D.K.3
Cooper, S.R.4
Lemonidis, K.M.5
Stecker, K.K.6
Martin, M.J.7
Crooke, R.M.8
-
49
-
-
0030841714
-
Transformed and immortalized cellular uptake of oligodeoxynucleoside phosphorothioates, 3′-alkylamino oligodeoxynucleotids, 2′-O-methyl oligoribonucleotides, oligodeoxynucleoside methylphosphonates, and peptide nucleic acids
-
GRAY, G.D., BASU, S., and WICKSTROM, E. (1997). Transformed and immortalized cellular uptake of oligodeoxynucleoside phosphorothioates, 3′-alkylamino oligodeoxynucleotids, 2′-O-methyl oligoribonucleotides, oligodeoxynucleoside methylphosphonates, and peptide nucleic acids. Biochem. Pharmacol. 53, 1465-1476.
-
(1997)
Biochem. Pharmacol.
, vol.53
, pp. 1465-1476
-
-
Gray, G.D.1
Basu, S.2
Wickstrom, E.3
-
50
-
-
0000876636
-
Measurement of macromolecular binding using electrospray mass spectrometry. Determination of diassociation constants for oligonucleotide-serum albumin complexes
-
GREIG, M., GAUS, H., CUMMINS, L., SASMOR, H., and GRIFFEY, R. (1995). Measurement of macromolecular binding using electrospray mass spectrometry. Determination of diassociation constants for oligonucleotide-serum albumin complexes. J. Am. Chem. Soc. 117, 10765-10766.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 10765-10766
-
-
Greig, M.1
Gaus, H.2
Cummins, L.3
Sasmor, H.4
Griffey, R.5
-
51
-
-
53149131335
-
Receptor-targeted gene delivery via folate-conjugated polyethylenimine
-
GUO, W., and LEE, R.L. (1999). Receptor-targeted gene delivery via folate-conjugated polyethylenimine. AAPS Pharm. Sci. 1(4), E19.
-
(1999)
AAPS Pharm. Sci.
, vol.1
, Issue.4
-
-
Guo, W.1
Lee, R.L.2
-
52
-
-
0030873845
-
32P]-labeled oligodeoxynucleoside methylphosphonate-neoglycopeptide conjugate, [YEE(ah-GalNAc)3]-SMCC-AET-pUmpT7, in the mouse
-
32P]-labeled oligodeoxynucleoside methylphosphonate-neoglycopeptide conjugate, [YEE(ah-GalNAc)3]-SMCC-AET-pUmpT7, in the mouse. Antisense Nucleic Acid Drug Dev. 7, 141-149.
-
(1997)
Antisense Nucleic Acid Drug Dev.
, vol.7
, pp. 141-149
-
-
Hangeland, J.J.1
Flesher, J.E.2
Deamond, S.F.3
Lee, Y.C.4
Ts, O.P.5
Rost, J.J.6
-
53
-
-
0032077216
-
An RGD-oligolysine peptide: A prototype construct for integrin-mediated gene delivery
-
HARBOTTLE, R.P., COOPER, R.G., HART, S.L., LADHOFF, A., McKAY, T., KNIGHT, A.M., WAGNER, E., MILLER, A.D., and COUTELLE, C. (1998). An RGD-oligolysine peptide: A prototype construct for integrin-mediated gene delivery. Hum. Gene Ther. 9, 1037-1047.
-
(1998)
Hum. Gene Ther.
, vol.9
, pp. 1037-1047
-
-
Harbottle, R.P.1
Cooper, R.G.2
Hart, S.L.3
Ladhoff, A.4
McKay, T.5
Knight, A.M.6
Wagner, E.7
Miller, A.D.8
Coutelle, C.9
-
54
-
-
3242695861
-
New route and novel formulations for delivery of antisense oligonucleotides
-
S.T. Crooke, ed. (Marcel Dekker, Inc, New York)
-
HARDEE, G.E., WEINBACH, S.P., and TILLMAN, L.G. (2001). New route and novel formulations for delivery of antisense oligonucleotides. In: Antisense Drug Technology: Principles, Strategies, and Applications. S.T. Crooke, ed. (Marcel Dekker, Inc, New York), pp. 759-832.
-
(2001)
Antisense Drug Technology: Principles, Strategies, and Applications
, pp. 759-832
-
-
Hardee, G.E.1
Weinbach, S.P.2
Tillman, L.G.3
-
55
-
-
0030918233
-
Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four-week study in cynomolgus monkeys
-
HENRY, S.P., BOLTE, H., AULETTA, C., and KORNBRUST, D.J. (1997a). Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four-week study in cynomolgus monkeys. Toxicology 120, 145-155.
-
(1997)
Toxicology
, vol.120
, pp. 145-155
-
-
Henry, S.P.1
Bolte, H.2
Auletta, C.3
Kornbrust, D.J.4
-
56
-
-
0030922755
-
Activation of the alternative pathway of complement by a phosphorothioate oligonucleotide: Potential mechanism of action
-
HENRY, S.P., GICLAS, P.C., LEEDS, J., PANGBURN, M., AULETTA, C., LEVIN, A.A., and KORNBRUST, D.J. (1997b). Activation of the alternative pathway of complement by a phosphorothioate oligonucleotide: Potential mechanism of action. J. Pharmacol. Exp. Ther. 281, 810-816.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.281
, pp. 810-816
-
-
Henry, S.P.1
Giclas, P.C.2
Leeds, J.3
Pangburn, M.4
Auletta, C.5
Levin, A.A.6
Kornbrust, D.J.7
-
57
-
-
0035989002
-
Folate-targeted gene transfer in vivo
-
HOFLAND, H.E., MASSON, C., IGINLA, S., OSETINSKY, I., REDDY, J.A., LEAMON, C.P., SCHERMAN, D., BESSODES, M., and WILS, P. (2002). Folate-targeted gene transfer in vivo. Mol. Ther. 5, 739-744.
-
(2002)
Mol. Ther.
, vol.5
, pp. 739-744
-
-
Hofland, H.E.1
Masson, C.2
Iginla, S.3
Osetinsky, I.4
Reddy, J.A.5
Leamon, C.P.6
Scherman, D.7
Bessodes, M.8
Wils, P.9
-
59
-
-
0026919380
-
Binding of antisense phosphorothioate oligonucleotides to murine lymphocytes is lineage specific and inducible
-
IVERSON, P.L., CROUSE, D., ZON, G., and PERRY, G. (1992). Binding of antisense phosphorothioate oligonucleotides to murine lymphocytes is lineage specific and inducible. Antisense Res. Dev. 2, 223-233.
-
(1992)
Antisense Res. Dev.
, vol.2
, pp. 223-233
-
-
Iverson, P.L.1
Crouse, D.2
Zon, G.3
Perry, G.4
-
60
-
-
0027074847
-
Human T-cell leukemia virus type I tax transformation is associated with increased uptake of oligodeoxynucleotides in vitro and in vivo
-
KITAJIMA, I., SHINOHARA, T., MINOR, T., BIBS, L., BILAKOVICS, J., AND NERENBERG, M. (1992). Human T-cell leukemia virus type I tax transformation is associated with increased uptake of oligodeoxynucleotides in vitro and in vivo. J. Biol. Chem. 267, 25881-25888.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 25881-25888
-
-
Kitajima, I.1
Shinohara, T.2
Minor, T.3
Bibs, L.4
Bilakovics, J.5
Nerenberg, M.6
-
61
-
-
0031953132
-
In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides
-
KREN, B.T., BANDYOPADHYAY, P., and STEER, C.J. (1998). In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides. Nat. Med. 4, 285-290.
-
(1998)
Nat. Med.
, vol.4
, pp. 285-290
-
-
Kren, B.T.1
Bandyopadhyay, P.2
Steer, C.J.3
-
62
-
-
0033230555
-
Folate copolymer-mediated transfection of cultured cells
-
LEAMON, C.P., WEIGL, D., and HENDREN, R.W. (1999). Folate copolymer-mediated transfection of cultured cells. Bioconjug. Chem. 10, 947-957.
-
(1999)
Bioconjug. Chem.
, vol.10
, pp. 947-957
-
-
Leamon, C.P.1
Weigl, D.2
Hendren, R.W.3
-
63
-
-
0029932762
-
Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer
-
LEE, R.J., and HUANG, L. (1996). Folate-targeted, anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer. J. Biol. Chem. 271, 8481-8487.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8481-8487
-
-
Lee, R.J.1
Huang, L.2
-
64
-
-
0034530988
-
Comparison of the pharmacokinetics of subcutaneous and intravenous administration of a phosphorothioate oligodeoxynucleotide in cynomolgus monkeys
-
LEEDS, J.M., HENRY, S.P., GEARY, R., BURCKIN, T., and LEVIN, A.A. (2000). Comparison of the pharmacokinetics of subcutaneous and intravenous administration of a phosphorothioate oligodeoxynucleotide in cynomolgus monkeys. Antisense Nucleic Acid Drug Dev. 10, 435-441.
-
(2000)
Antisense Nucleic Acid Drug Dev.
, vol.10
, pp. 435-441
-
-
Leeds, J.M.1
Henry, S.P.2
Geary, R.3
Burckin, T.4
Levin, A.A.5
-
65
-
-
0032697942
-
A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides
-
LEVIN, A.A. (1999). A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochim. Biophys. Acta 1489, 69-84.
-
(1999)
Biochim. Biophys. Acta
, vol.1489
, pp. 69-84
-
-
Levin, A.A.1
-
66
-
-
0031048990
-
Limitations of cationic liposomes for antisense oligonucleotide delivery in vivo
-
LITZINGER, D.C. (1997). Limitations of cationic liposomes for antisense oligonucleotide delivery in vivo. J. Liposome Res. 7, 51-56.
-
(1997)
J. Liposome Res.
, vol.7
, pp. 51-56
-
-
Litzinger, D.C.1
-
67
-
-
0036137646
-
Pharmacokinetics of Bcl-2 antisense oligonucleotide (G3139) combined with doxorubicin in SCID mice bearing human breast cancer solid tumor xenografts
-
LOPES, D., and MAYER, L.D. (2002). Pharmacokinetics of Bcl-2 antisense oligonucleotide (G3139) combined with doxorubicin in SCID mice bearing human breast cancer solid tumor xenografts. Cancer Chemother. Pharmacol. 49, 57-68.
-
(2002)
Cancer Chemother. Pharmacol.
, vol.49
, pp. 57-68
-
-
Lopes, D.1
Mayer, L.D.2
-
68
-
-
0028863071
-
Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes
-
MAHATO, R.I., KAWABATA, K., NOMURA, T., TAKAKURA, Y., and HASHIDA, M. (1995). Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes. J. Pharm. Sci. 84, 1267-1271.
-
(1995)
J. Pharm. Sci.
, vol.84
, pp. 1267-1271
-
-
Mahato, R.I.1
Kawabata, K.2
Nomura, T.3
Takakura, Y.4
Hashida, M.5
-
69
-
-
0030907837
-
Physiocochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine)
-
MAHATO, R.I., TAKEMURA, S., AKAMATSU, K., NISHIKAWA, M., TAKAKURA, Y., and HASHIDA, M. (1997). Physiocochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine). Biochem. Pharmacol. 53, 887-895.
-
(1997)
Biochem. Pharmacol.
, vol.53
, pp. 887-895
-
-
Mahato, R.I.1
Takemura, S.2
Akamatsu, K.3
Nishikawa, M.4
Takakura, Y.5
Hashida, M.6
-
70
-
-
0033749825
-
Intercellular adhesion molecule-1 suppression in skin by topical delivery of anti-sense oligonucleotides
-
MEHTA, R.C., STECKER, K.K., COOPER, S.R., TEMPLIN, M.V., TSAI, Y.J., CONDON, T.P., BENNETT, C.F., and HARDEE, G.E. (2000). Intercellular adhesion molecule-1 suppression in skin by topical delivery of anti-sense oligonucleotides. J. Invest. Dermatol. 115, 805-812.
-
(2000)
J. Invest. Dermatol.
, vol.115
, pp. 805-812
-
-
Mehta, R.C.1
Stecker, K.K.2
Cooper, S.R.3
Templin, M.V.4
Tsai, Y.J.5
Condon, T.P.6
Bennett, C.F.7
Hardee, G.E.8
-
71
-
-
0033060190
-
Evaluation of the renal effects of an antisense phosphorothioate oligodeoxynucleotide in monkeys
-
MONTEITH, D.K., HORNER, M.J., GILLETT, N.A., BUTLER, M., GEARY, R., BURCKIN, T., USHIRO-WATANABE, T., and LEVIN, A.A. (1999). Evaluation of the renal effects of an antisense phosphorothioate oligodeoxynucleotide in monkeys. Toxicol. Pathol. 27, 307-317.
-
(1999)
Toxicol. Pathol.
, vol.27
, pp. 307-317
-
-
Monteith, D.K.1
Horner, M.J.2
Gillett, N.A.3
Butler, M.4
Geary, R.5
Burckin, T.6
Ushiro-Watanabe, T.7
Levin, A.A.8
-
72
-
-
0032480779
-
Novel therapeutic strategy for atherosclerosis: Ribozyme oligonucleotides against apolipoprotein(a) selectively inhibit apolipoprotein(a) but not plasminogen gene expression
-
MORISHITA, R., YAMADA, S., YAMAMOTO, K., TOMITA, N., KIDA, I., SAKURABAYASHI, I., KIKUCHI, A., KANEDA, Y., LAWN, R., HIGAKI, J., and OGIHARA, T. (1998). Novel therapeutic strategy for atherosclerosis: Ribozyme oligonucleotides against apolipoprotein(a) selectively inhibit apolipoprotein(a) but not plasminogen gene expression. Circulation 98, 1898-1904.
-
(1998)
Circulation
, vol.98
, pp. 1898-1904
-
-
Morishita, R.1
Yamada, S.2
Yamamoto, K.3
Tomita, N.4
Kida, I.5
Sakurabayashi, I.6
Kikuchi, A.7
Kaneda, Y.8
Lawn, R.9
Higaki, J.10
Ogihara, T.11
-
73
-
-
0029898537
-
Inhibition of hepatitis B virus replication by targeted pretreatment of complexed antisense DNA in vitro
-
NAKAZONO, K., ITO, Y., WU, C.H., and WU, G.Y. (1996). Inhibition of hepatitis B virus replication by targeted pretreatment of complexed antisense DNA in vitro. Hepatology 23, 1297-1303.
-
(1996)
Hepatology
, vol.23
, pp. 1297-1303
-
-
Nakazono, K.1
Ito, Y.2
Wu, C.H.3
Wu, G.Y.4
-
74
-
-
0029836444
-
Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice
-
NEURATH, M.F., PETTERSSON, S., MEYER ZUM BUSCHENFELDE, K.H., and STROBER, W. (1996). Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat. Med. 2, 998-1004.
-
(1996)
Nat. Med.
, vol.2
, pp. 998-1004
-
-
Neurath, M.F.1
Pettersson, S.2
Meyer Zum Buschenfelde, K.H.3
Strober, W.4
-
75
-
-
0031950147
-
Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): Comparison with other delivery routes
-
NICKLIN, P.L., BAYLEY, D., GIDDINGS, J., CRAIG, S.J., CUMMINS, L.L., HASTEWELL, J.G., and PHILLIPS, J.A. (1998a). Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): Comparison with other delivery routes. Pharm. Res. 15, 583-591.
-
(1998)
Pharm. Res.
, vol.15
, pp. 583-591
-
-
Nicklin, P.L.1
Bayley, D.2
Giddings, J.3
Craig, S.J.4
Cummins, L.L.5
Hastewell, J.G.6
Phillips, J.A.7
-
76
-
-
0000433389
-
Pharmacokinetic properties of phosphorothioates in animals - Absorption, distribution, metabolism and elimination
-
S. Crooke, ed. (Springer-Verlag, Berlin)
-
NICKLIN, P.L., CRAIG, S., and PHILLIPS, J. (1998b). Pharmacokinetic properties of phosphorothioates in animals - Absorption, distribution, metabolism and elimination. In: Antisense Research and Applications. S. Crooke, ed. (Springer-Verlag, Berlin), pp. 141-168.
-
(1998)
Antisense Research and Applications
, pp. 141-168
-
-
Nicklin, P.L.1
Craig, S.2
Phillips, J.3
-
77
-
-
0031025249
-
DNA antisense therapy for asthma in an animal model
-
NYCE, J.W., and METZGER, W.J. (1997). DNA antisense therapy for asthma in an animal model. Nature 385, 721-725.
-
(1997)
Nature
, vol.385
, pp. 721-725
-
-
Nyce, J.W.1
Metzger, W.J.2
-
78
-
-
0029956529
-
Antisense and the kidney
-
OBERBAUER, R., MURER, H., SCHREINER, G.F., and MEYER, T.W. (1996). Antisense and the kidney. Kidney Blood Press. Res. 19, 221-224.
-
(1996)
Kidney Blood Press. Res.
, vol.19
, pp. 221-224
-
-
Oberbauer, R.1
Murer, H.2
Schreiner, G.F.3
Meyer, T.W.4
-
79
-
-
0029166689
-
Renal uptake of an 18-mer phosphorothioate oligonucleotide
-
OBERBAUER, R., SCHREINER, G.F., and MEYER, T.W. (1995). Renal uptake of an 18-mer phosphorothioate oligonucleotide. Kidney Int. 48, 1226-1232.
-
(1995)
Kidney Int.
, vol.48
, pp. 1226-1232
-
-
Oberbauer, R.1
Schreiner, G.F.2
Meyer, T.W.3
-
80
-
-
0036207252
-
Altered organ accumulation of oligonucleotides using polyethyleneimine grafted with poly(ethylene oxide) or pluronic as carrier
-
OCHIETTI, B., GUERIN, N., VINOGRADOV, S.V., ST-PIERRE, Y., LEMIEUX, P., KABANOV, A.V., and ALAKHOV, Y. (2002). Altered organ accumulation of oligonucleotides using polyethyleneimine grafted with poly(ethylene oxide) or pluronic as carrier. J. Drug Target. 10(2), 113-121.
-
(2002)
J. Drug Target
, vol.10
, Issue.2
, pp. 113-121
-
-
Ochietti, B.1
Guerin, N.2
Vinogradov, S.V.3
St-Pierre, Y.4
Lemieux, P.5
Kabanov, A.V.6
Alakhov, Y.7
-
81
-
-
0032938324
-
PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
-
OGRIS, M., BRUNNER, S., SCHULLER, S., KIRCHEIS, R., and WAGNER, E. (1999). PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther. 6, 595-605.
-
(1999)
Gene Ther.
, vol.6
, pp. 595-605
-
-
Ogris, M.1
Brunner, S.2
Schuller, S.3
Kircheis, R.4
Wagner, E.5
-
82
-
-
0036636074
-
Nucleic acid therapeutics: Basic principles and recent applications
-
OPALINSKA, J.B., and GEWIRTZ, A.M. (2002). Nucleic acid therapeutics: Basic principles and recent applications. Nat. Rev. Drug Discov. 1, 503-514.
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 503-514
-
-
Opalinska, J.B.1
Gewirtz, A.M.2
-
83
-
-
0030940283
-
Alpha v integrins as receptors for tumor targeting by circulating ligands
-
PASQUALINI, R., KOIVUNEN, E., and RUOSLAHTI, E. (1997). Alpha v integrins as receptors for tumor targeting by circulating ligands. Nat. Biotechnol. 15, 542-546.
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 542-546
-
-
Pasqualini, R.1
Koivunen, E.2
Ruoslahti, E.3
-
84
-
-
0032534034
-
Construction of a directed hammerhead ribozyme library: Towards the identification of optimal target sites for antisense-mediated gene inhibition
-
PIERCE, M.L., and RUFFNER, D.E. (1998). Construction of a directed hammerhead ribozyme library: Towards the identification of optimal target sites for antisense-mediated gene inhibition. Nucleic Acids Res. 26, 5093-5101.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 5093-5101
-
-
Pierce, M.L.1
Ruffner, D.E.2
-
85
-
-
0029034897
-
Cell and tissue distribution of synthetic oligonucleotides in healthy and tumor-bearing nude mice. An autoradiographic, immunohistological, and direct fluorescence microscopy study
-
PLENAT, F., KLEIN-MONHOVEN, N., MARIE, B., VIGNAUD, J.M., and DUPREZ, A. (1995). Cell and tissue distribution of synthetic oligonucleotides in healthy and tumor-bearing nude mice. An autoradiographic, immunohistological, and direct fluorescence microscopy study. Am. J. Pathol. 147, 124-135.
-
(1995)
Am. J. Pathol.
, vol.147
, pp. 124-135
-
-
Plenat, F.1
Klein-Monhoven, N.2
Marie, B.3
Vignaud, J.M.4
Duprez, A.5
-
86
-
-
0032407415
-
In vivo delivery of antisense oligonucleotides into rat Kupffer cells
-
PONNAPPA, B., DEY, I., TU, G.-C., ZHOU, F., CAO, Q.-N., and ISRAEL, Y. (1998). In vivo delivery of antisense oligonucleotides into rat Kupffer cells. J. Lipsome Res. 8, 521-535.
-
(1998)
J. Lipsome Res.
, vol.8
, pp. 521-535
-
-
Ponnappa, B.1
Dey, I.2
Tu, G.-C.3
Zhou, F.4
Cao, Q.-N.5
Israel, Y.6
-
87
-
-
0035019089
-
In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-alpha in rats
-
PONNAPPA, B.C., DEY, I., TU, G.C., ZHOU, F., AINI, M., CAO, Q.N., and ISRAEL, Y. (2001). In vivo delivery of antisense oligonucleotides in pH-sensitive liposomes inhibits lipopolysaccharide-induced production of tumor necrosis factor-alpha in rats. J. Pharmacol. Exp. Ther. 297, 1129-1136.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.297
, pp. 1129-1136
-
-
Ponnappa, B.C.1
Dey, I.2
Tu, G.C.3
Zhou, F.4
Aini, M.5
Cao, Q.N.6
Israel, Y.7
-
88
-
-
0032726144
-
Optimization of folate-conjugated liposomal vectors for folate receptor-mediated gene therapy
-
REDDY, J.A., DEAN, D., KENNEDY, M.D., and LOW, P.S. (1999). Optimization of folate-conjugated liposomal vectors for folate receptor-mediated gene therapy. J. Pharm. Sci. 88, 1112-1118.
-
(1999)
J. Pharm. Sci.
, vol.88
, pp. 1112-1118
-
-
Reddy, J.A.1
Dean, D.2
Kennedy, M.D.3
Low, P.S.4
-
89
-
-
0036186558
-
Gene repair in the new age of gene therapy
-
RICHARDSON, P.D., KREN, B.T., and STEER, C.J. (2002). Gene repair in the new age of gene therapy. Hepatology 35, 512-518.
-
(2002)
Hepatology
, vol.35
, pp. 512-518
-
-
Richardson, P.D.1
Kren, B.T.2
Steer, C.J.3
-
90
-
-
0029761186
-
Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligodeoxynucleotides in mice
-
RIFAI, A., BRYSCH, W., FADDEN, K., CLARK, J., and SCHLINGENSIEPEN, K.H. (1996). Clearance kinetics, biodistribution, and organ saturability of phosphorothioate oligodeoxynucleotides in mice. Am. J. Pathol. 149, 717-725.
-
(1996)
Am. J. Pathol.
, vol.149
, pp. 717-725
-
-
Rifai, A.1
Brysch, W.2
Fadden, K.3
Clark, J.4
Schlingensiepen, K.H.5
-
92
-
-
0035181482
-
Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice
-
SATO, N., KOBAYASHI, H., SAGA, T., NAKAMOTO, Y., ISHIMORI, T., TOGASHI, K., FUJIBAYASHI, Y., KONISHI, J., and BRECHBIEL, M.W. (2001). Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice. Clin. Cancer Res. 7, 3606-3612.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 3606-3612
-
-
Sato, N.1
Kobayashi, H.2
Saga, T.3
Nakamoto, Y.4
Ishimori, T.5
Togashi, K.6
Fujibayashi, Y.7
Konishi, J.8
Brechbiel, M.W.9
-
93
-
-
0030440928
-
Disposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake
-
SAWAI, K., MAHATO, R.I., OKA, Y., TAKAKURA, Y., and HASHIDA, M. (1996). Disposition of oligonucleotides in isolated perfused rat kidney: Involvement of scavenger receptors in their renal uptake. J. Pharmacol. Exp. Ther. 279 284-290.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.279
, pp. 284-290
-
-
Sawai, K.1
Mahato, R.I.2
Oka, Y.3
Takakura, Y.4
Hashida, M.5
-
94
-
-
0037161316
-
Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations
-
SHI, G., GUO, W., STEPHENSON, S.M., and LEE, R.J. (2002). Efficient intracellular drug and gene delivery using folate receptor-targeted pH-sensitive liposomes composed of cationic/anionic lipid combinations. J. Control. Release 80, 309-319.
-
(2002)
J. Control. Release
, vol.80
, pp. 309-319
-
-
Shi, G.1
Guo, W.2
Stephenson, S.M.3
Lee, R.J.4
-
95
-
-
0037107886
-
RNAi: Gene-silencing in therapeutic intervention
-
SHUEY, D.J., McCALLUS, D.E., and GIORDANO, T. (2002) RNAi: Gene-silencing in therapeutic intervention. Drug Discov. Today 7, 1040-1046.
-
(2002)
Drug Discov. Today
, vol.7
, pp. 1040-1046
-
-
Shuey, D.J.1
McCallus, D.E.2
Giordano, T.3
-
96
-
-
0034739611
-
Selecting optimal antisense reagents
-
SOHAIL, M., and SOUTHERN, E.M. (2000). Selecting optimal antisense reagents. Adv. Drug Deliv. Rev. 44, 23-34.
-
(2000)
Adv. Drug Deliv. Rev.
, vol.44
, pp. 23-34
-
-
Sohail, M.1
Southern, E.M.2
-
97
-
-
0024202897
-
Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides
-
SPITZER, S., and ECKSTEIN, F. (1988). Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides. Nucleic Acids Res. 16, 11691-11704.
-
(1988)
Nucleic Acids Res.
, vol.16
, pp. 11691-11704
-
-
Spitzer, S.1
Eckstein, F.2
-
98
-
-
0343882023
-
Targeted drug delivery via the folate receptor
-
SUDIMACK, J., and LEE, R.J. (2000). Targeted drug delivery via the folate receptor. Adv. Drug Deliv. Rev. 41, 147-162.
-
(2000)
Adv. Drug Deliv. Rev.
, vol.41
, pp. 147-162
-
-
Sudimack, J.1
Lee, R.J.2
-
99
-
-
0029762060
-
Changes in plasma lipoprotein cholesterol levels by antisense oligodeoxynucleotides against cholesteryl ester transfer protein in cholesterol-fed rabbits
-
SUGANO, M., and MAKINO, N. (1996). Changes in plasma lipoprotein cholesterol levels by antisense oligodeoxynucleotides against cholesteryl ester transfer protein in cholesterol-fed rabbits. J. Biol. Chem. 271, 19080-19083.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19080-19083
-
-
Sugano, M.1
Makino, N.2
-
100
-
-
0032570684
-
Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits
-
SUGANO, M., MAKINO, N., SAWADA, S., OTSUKA, S. WATANABE, M., OKAMOTO, H., KAMADA, M., and MIZUSHIMA, A. (1998). Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits. J. Biol. Chem. 273, 5033-5036.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5033-5036
-
-
Sugano, M.1
Makino, N.2
Sawada, S.3
Otsuka, S.4
Watanabe, M.5
Okamoto, H.6
Kamada, M.7
Mizushima, A.8
-
101
-
-
0035721542
-
Respirable antisense oligonucleotides: A new drug class for respiratory disease
-
TANAKA, M., and NYCE, J.W. (2001). Respirable antisense oligonucleotides: A new drug class for respiratory disease. Respir. Res. 2, 5-9.
-
(2001)
Respir. Res.
, vol.2
, pp. 5-9
-
-
Tanaka, M.1
Nyce, J.W.2
-
102
-
-
0033763150
-
Pharmacokinetic and toxicity profile of a phosphorothioate oligonucleotide following inhalation delivery to lung in mice
-
TEMPLIN, M.V., LEVIN, A.A., GRAHAM, M.J., ABERG, P.M., AXELSSON, B.I., BUTLER, M., GEARY, R.S., and BENNETT, C.F. (2000). Pharmacokinetic and toxicity profile of a phosphorothioate oligonucleotide following inhalation delivery to lung in mice. Antisense Nucleic Acid Drug Dev. 10, 359-368.
-
(2000)
Antisense Nucleic Acid Drug Dev.
, vol.10
, pp. 359-368
-
-
Templin, M.V.1
Levin, A.A.2
Graham, M.J.3
Aberg, P.M.4
Axelsson, B.I.5
Butler, M.6
Geary, R.S.7
Bennett, C.F.8
-
103
-
-
0034130453
-
Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production
-
TORTORA, G., BIANCO, R., DAMIANO, V., FONTANINI, G., DE PLACIDO, S., BIANCO, A.R., and CIARDIELLO, F. (2000). Oral antisense that targets protein kinase A cooperates with taxol and inhibits tumor growth, angiogenesis, and growth factor production. Clin. Cancer Res. 6, 2506-2512.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2506-2512
-
-
Tortora, G.1
Bianco, R.2
Damiano, V.3
Fontanini, G.4
De Placido, S.5
Bianco, A.R.6
Ciardiello, F.7
-
104
-
-
0035674731
-
Oral administration of a novel taxane, an antisense oligonucleotide targeting protein kinase A, and the epidermal growth factor receptor inhibitor Iressa causes cooperative antitumor and antiangiogenic activity
-
TORTORA, G., CAPUTO, R., DAMIANO, V., FONTANINI, G., MELISI, D., VENEZIANI, B.M., ZUNINO, F., BIANCO, A.R., and CIARDIELLO, F. (2001). Oral administration of a novel taxane, an antisense oligonucleotide targeting protein kinase A, and the epidermal growth factor receptor inhibitor Iressa causes cooperative antitumor and antiangiogenic activity. Clin. Cancer Res. 7, 4156-4163.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 4156-4163
-
-
Tortora, G.1
Caputo, R.2
Damiano, V.3
Fontanini, G.4
Melisi, D.5
Veneziani, B.M.6
Zunino, F.7
Bianco, A.R.8
Ciardiello, F.9
-
105
-
-
0034669529
-
Folate gains momentum as a vehicle for drug delivery
-
VASTAG, B. (2000). Folate gains momentum as a vehicle for drug delivery. J. Natl. Cancer Inst. 92, 1800-1801.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 1800-1801
-
-
Vastag, B.1
-
106
-
-
17344372249
-
Modified oligonucleotides: Synthesis and strategy for users
-
VERMA, S., and ECKSTEIN, F. (1998). Modified oligonucleotides: Synthesis and strategy for users. Annu. Rev. Biochem. 67, 99-134.
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 99-134
-
-
Verma, S.1
Eckstein, F.2
-
107
-
-
0028303251
-
Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. In vitro model for selection of target sequence
-
WAKITA, T., and WANDS, J.R. (1994). Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. In vitro model for selection of target sequence. J. Biol. Chem. 269, 14205-14210.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 14205-14210
-
-
Wakita, T.1
Wands, J.R.2
-
108
-
-
0033598705
-
Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration
-
WANG, H., CAI, Q., ZENG, X., YU, D., AGRAWAL, S., and ZHANG, R. (1999). Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration. Proc. Natl. Acad. Sci. USA 96(24), 13989-13994.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, Issue.24
, pp. 13989-13994
-
-
Wang, H.1
Cai, Q.2
Zeng, X.3
Yu, D.4
Agrawal, S.5
Zhang, R.6
-
109
-
-
0028924955
-
Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol
-
WANG, S., LEE, R.J., CAUCHON, G., GORENSTEIN, D.G., and LOW, P.S. (1995). Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol. Proc. Natl. Acad. Sci. USA 92, 3318-3322.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3318-3322
-
-
Wang, S.1
Lee, R.J.2
Cauchon, G.3
Gorenstein, D.G.4
Low, P.S.5
-
110
-
-
0034003354
-
Folate-targeted non-viral DNA vectors for cancer gene therapy
-
WARD, C.M. (2000). Folate-targeted non-viral DNA vectors for cancer gene therapy. Curr. Opin. Mol. Ther. 2, 182-187.
-
(2000)
Curr. Opin. Mol. Ther.
, vol.2
, pp. 182-187
-
-
Ward, C.M.1
-
111
-
-
0032873658
-
Preclinical and clinical experience of antisense therapy for solid tumors
-
WEBB, M.S., and ZON, G. (1999). Preclinical and clinical experience of antisense therapy for solid tumors. Curr. Opin. Mol. Ther. 1, 458-463.
-
(1999)
Curr. Opin. Mol. Ther.
, vol.1
, pp. 458-463
-
-
Webb, M.S.1
Zon, G.2
-
112
-
-
0035524007
-
Integrins as targets of angiogenesis inhibition
-
WESTLIN, W.F. (2001). Integrins as targets of angiogenesis inhibition. Cancer J. 7(Suppl 3), S139-S143.
-
(2001)
Cancer J.
, vol.7
, Issue.SUPPL. 3
-
-
Westlin, W.F.1
-
113
-
-
0031970637
-
Therapeutic repair of mutated nucleic acid sequences
-
WOOLF, T.M. (1998). Therapeutic repair of mutated nucleic acid sequences. Nat. Biotechnol. 16, 341-344.
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 341-344
-
-
Woolf, T.M.1
-
114
-
-
0034945428
-
Antisense oligonucleotides in cutaneous therapy
-
WRAIGHT, C.J., and WHITE, P.J. (2001). Antisense oligonucleotides in cutaneous therapy. Pharmacol. Ther. 90, 89-104.
-
(2001)
Pharmacol. Ther.
, vol.90
, pp. 89-104
-
-
Wraight, C.J.1
White, P.J.2
-
115
-
-
0026688793
-
Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides
-
WU, G.Y., and WU, C.H. (1992). Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides. J. Biol. Chem. 267, 12436-12439.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 12436-12439
-
-
Wu, G.Y.1
Wu, C.H.2
-
116
-
-
0036518616
-
Targeting hepatocytes for drug and gene delivery: Emerging novel approaches and applications
-
WU, J., NANTZ, M.H., and ZERN, M.A. (2002). Targeting hepatocytes for drug and gene delivery: Emerging novel approaches and applications. Front. Biosci. 7, d717-d725.
-
(2002)
Front. Biosci.
, vol.7
-
-
Wu, J.1
Nantz, M.H.2
Zern, M.A.3
-
117
-
-
0035138215
-
Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey
-
YU, R.Z., GEARY, R.S., LEEDS, J.M., WATANABE, T., MOORE, M., FITCHETT, J., MATSON, J., BURCKIN, T., TEMPLIN, M.V., and LEVIN, A.A. (2001a). Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey. J. Pharm. Sci. 90, 182-193.
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 182-193
-
-
Yu, R.Z.1
Geary, R.S.2
Leeds, J.M.3
Watanabe, T.4
Moore, M.5
Fitchett, J.6
Matson, J.7
Burckin, T.8
Templin, M.V.9
Levin, A.A.10
-
118
-
-
0035142861
-
Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice
-
YU, R.Z., ZHANG, H., GEARY, R.S., GRAHAM, M., MASARJIAN, L., LEMONIDIS, K., CROOKE, R., DEAN, N.M., and LEVIN, A.A. (2001b). Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice. J. Pharmacol. Exp. Ther. 296(2), 388-395.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, Issue.2
, pp. 388-395
-
-
Yu, R.Z.1
Zhang, H.2
Geary, R.S.3
Graham, M.4
Masarjian, L.5
Lemonidis, K.6
Crooke, R.7
Dean, N.M.8
Levin, A.A.9
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