Identification and characterization of second-generation antisense oligonucleotides

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 3, 1997, Pages 229-233

  Dean, Nicholas M ^a   Griffey, Richard H ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

CONFERENCE PAPER; DRUG DESIGN; DRUG STRUCTURE; GENE REPRESSION; PRIORITY JOURNAL;

EID: 0030839546     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.229     Document Type: Conference Paper

References (5)

1. ALTMANN, K.-H., DEAN, N.M., FABBRO, D., FREIER, S.M., GEIGER, T., HANER, R., HUSKEN, D., MARTIN, P., MONIA, B.P., MULLER, M., NATT, F., NICKLIN, P., PHILLIPS, J., PIELES, U., SASMOR, H., and MOSER, H.E. (1996). Second generation of antisense oligonucleotides: From nuclease resistance to biological efficacy in animals. Chimia 50, 168-176.
2. CHIANG, M.-Y., CHAN, H., ZOUNES, M.A., FREIER, S.M., LIMA, W.F., and BENNETT, C.F. (1991). Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms. J. Biol. Chem. 266, 18162-18171.
3. COOK, P.D. (1993). Medicinal chemistry strategies for antisense research. In: Antisense Research and Applications. S.T. Crooke and B. Lebleu, eds. (CRC Press, Boca Raton, FL), pp. 149-187.
4. CUMMINS, L.L., OWENS, S.R., RISEN, L.M., LESNIK, E.A., FREIER, S.M., McGEE, D., GUINOSSO. C.J., and COOK, P.D. (1995). Characterization of fully 2′-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity. Nucleic Acids Res. 23, 2019-2024.
5. WALDER, R.Y., and WALDER, J.A. (1988). Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. Proc. Natl. Acad. Sci. USA 85, 5011-5015.