Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302)

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 3, 1997, Pages 1173-1180

  Glover, Josephine M ^a   Leeds, Janet M ^a   Mant, Timothy G K ^b   Amin, Dipti ^b   Kisner, Daniel L ^a   Zuckerman, Joan E ^a   Geary, Richard S ^a   Levin, Arthur A ^a   Shanahan Jr , William R ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b Guy's Drug Research Unit Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALICAFORSEN; ANTISENSE OLIGODEOXYNUCLEOTIDE; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A; INTERCELLULAR ADHESION MOLECULE 1; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ADULT; ANTICOAGULATION; AREA UNDER THE CURVE; ARTICLE; CELL SURFACE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; HUMAN EXPERIMENT; IMMUNE SYSTEM; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; PARTIAL THROMBOPLASTIN TIME; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEADY STATE;

ADULT; DOUBLE-BLIND METHOD; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OLIGONUCLEOTIDES, ANTISENSE; THIONUCLEOTIDES;

EID: 0030987678     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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