Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four-week study in cynomolgus monkeys

Toxicology

Volumn 120, Issue 2, 1997, Pages 145-155

  Henry, Scott P ^a   Bolte, Henry ^b   Auletta, Carol ^b   Kornbrust, Douglas J ^c  

^a ISIS PHARMACEUTICALS   (United States)

^b PharmacoLSR Inc   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

Antisense; ICAM 1; Monkey; Oligonucleotide; Phosphorothioate; Toxicology

Indexed keywords

ALICAFORSEN; ANTISENSE OLIGONUCLEOTIDE; INTERCELLULAR ADHESION MOLECULE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLEEDING; BLOOD CLOTTING TIME; CELL VACUOLE; CONTROLLED STUDY; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MONKEY; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; URINALYSIS;

ANIMALS; BLOOD CHEMICAL ANALYSIS; BLOOD UREA NITROGEN; CREATININE; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILS; ERYTHROCYTES; FEMALE; HEMORRHAGE; HUMANS; INJECTIONS, INTRAVENOUS; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY TUBULES, PROXIMAL; MACACA FASCICULARIS; MALE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OLIGONUCLEOTIDES, ANTISENSE; PARTIAL THROMBOPLASTIN TIME; PLATELET COUNT; PROTHROMBIN TIME; RNA, MESSENGER; THIONUCLEOTIDES;

ANIMALIA; MACACA FASCICULARIS;

EID: 0030918233     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(97)03661-5     Document Type: Article

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