Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes

Bioconjugate Chemistry

Volumn 13, Issue 2, 2002, Pages 295-302

  Biessen, Erik A L ^a   Sliedregt Bol, Karen ^b   'T Hoen, Peter A Chr ^a   Prince, Perry ^a   Van der Bilt, Erica ^a   Valentijn, A Rob P M ^b   Meeuwenoord, Nico J ^b   Princen, Hans ^c   Bijsterbosch, Martin K ^a   Van der Marel, Gijs A ^b   Van Boom, Jacques H ^b   Van Berkel, Theo J C ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GENE EXPRESSION; NUCLEIC ACIDS;

ANTISENSE PEPTIDES; ASIALOGLYCOPROTEIN RECEPTORS; BIODISTRIBUTIONS; HEPATOCYTES; HIGH AFFINITY; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEINS; PEPTIDE NUCLEIC ACID; PRODRUGS; PROTEIN EXPRESSIONS; PROTEIN GENES;

PEPTIDES;

EUKARYOTA;

ALPHA FETOPROTEIN; ASIALOFETUIN; ASIALOGLYCOPROTEIN; CARRIER PROTEIN; MESSENGER RNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PEPTIDE NUCLEIC ACID; PRODRUG;

ANIMAL; ARTICLE; C57BL MOUSE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KINETICS; LIVER CELL; LIVER MICROSOME; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL;

ALPHA-FETOPROTEINS; ANIMALS; ASIALOGLYCOPROTEINS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; DRUG DESIGN; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; KINETICS; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PEPTIDE NUCLEIC ACIDS; PRODRUGS; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0036009641     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc015550g     Document Type: Article

References (33)

1. Progress in developing PNA as a gene-targeted drug
2. Peptide nucleic acid (PNA): Its medical and biotechnical applications and promise for the future
3. Stability of peptide nucleic acids in human serum and cellular extracts
4. PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules
5. Peptide nucleic acids (PNAs) containing thymine monomers derived from chiral amino acids: Hybridisation and solubility properties of D-lysine PNA
6. Transformed and immortalized cellular uptake of oligodeoxynucleoside phosphorothioates, 3′-alkylamino oligodeoxynucleotides, 2′-O-methyloligoribonucleotides, oligodeoxynucleoside methylphosphonates, and peptide nucleic acids
7. An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers
8. Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand
9. Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA
10. Antisense and antigene properties of peptide nucleic acids
11. Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells
12. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo
13. Synthesis and characterization of a peptide nucleic acid conjugated to a D-peptide analogue of insulin-like growth factor 1 for increased cellular uptake
14. Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo
15. An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: Initial applications in anti-HIV antisense drug delivery to the brain
16. Mouse microsomal triglyceride transfer protein large subunit: cDNA cloning, tissue-specific expression, and chromosomal localization
17. Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice
18. Evidence that microsomal triglyceride transfer protein is limiting in the production of apolipoprotein B-containing lipoproteins in hepatic cells
19. Specific targeting of the antiviral drug 5-iodo-2′-deoxyuridine to the parenchymal liver cell using lactosylated poly-L-lysine
20. Solid-phase synthesis of lysine-based cluster galactosides with high affinity for the asialoglycoprotein receptor
21. In vivo and in vitro uptake and degradation of acetylated low-density lipoproteins by rat liver endothelial, Kupffer, and parenchymal cells
22. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
23. RNA quantitation by fluorescence-based solution assay: RiboGreen reagent characterization
24. New hepatotrophic prodrugs of the antiviral nucleoside 9-(2-Phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity
25. Pharmacokinetics of 99mTc-labeled oligonucleotides
26. Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo
27. 3]-SMCC-AET-pUmpT7, in the mouse
28. Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits
29. Antisense DNA delivery in vivo: Liver targeting by receptor-mediated uptake
30. Expanded sequence dependence of thermodynamic parameters provides robust prediction of RNA secondary structure
31. Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes