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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 19, 2005, Pages 4336-4341

Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors

(15) Holmes, Christopher P a Li, Xianfeng a Pan, Yijun a Xu, Caiding a Bhandari, Ashok a Moody, Claire M a Miguel, Joy A a Ferla, Steven W a De Francisco, M Nuria a Frederick, Brian T a Zhou, Siqun a Macher, Natalie a Jang, Larry a Irvine, Jennifer D a Grove, J Russell a

a AFFYMAX RESEARCH INSTITUTE (United States)

Author keywords

PTP1B inhibitors; Sulfonamides

Indexed keywords

AMIDE; AMINE; CARBENOID; FLUORINE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; SULFONAMIDE;

ALKYLATION; ARTICLE; BROMINATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IC 50; STRUCTURE ACTIVITY RELATION;

ANIMALS; HUMANS; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50; PHOSPHONIC ACIDS; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 23944466408 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.06.061 Document Type: Article

Times cited : (40)

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