The development of potent non-peptidic PTP-1B inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 4, 2004, Pages 1039-1042

  Dufresne, Claude ^a   Roy, Patrick ^a   Wang, Zhaoyin ^a   Asante Appiah, Ernest ^a   Cromlish, Wanda ^a   Boie, Yves ^a   Forghani, Farnaz ^a   Desmarais, Sylvie ^a   Wang, Qingping ^a   Skorey, Kathryn ^a   Waddleton, Deena ^a   Ramachandran, Chidambaram ^a   Kennedy, Brian P ^a   Xu, Lijing ^a   Gordon, Robert ^a   Chan, Chi Chung ^a   Leblanc, Yves ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FUNCTIONAL GROUP; METHYLPHOSPHONIC ACID; PEPTIDE LIBRARY; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR;

ARTICLE; COMPARATIVE STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG STRUCTURE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 10744228866     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.048     Document Type: Article

References (29)

1. Evans J.L., Jallal B. Exp. Opin. Invest. Drugs. 8:1999;139.
2. Vague P., Raccah D. Horm. Res. 38:1992;28.
3. Taylor S.I., Accili D., Imai Y. Diabetes. 43:1994;735.
4. Reaven G.M. Diabetes/Metab. Rev. 9(Supp. 1):1993;5. S.
5. Kahn C.R. Diabetes. 43:1994;1066.
6. Elchebly M., Payette P., Michaliszyn E., Cromlish W., Collins S., Loy A.L., Normandin D., Cheng A., Himms-Hagen J., Chan C.-C., Ramachandran C., Gresser M.J., Tremblay M.L., Kennedy B.P. Science. 283:1999;1544.
7. Klaman L.D., Boss O., Peroni O.D., Kim J.K., Martino J.L., Zabolotny J.M., Moghal N., Lubkin M., Kim Y.B., Sharpe A.H., Stricker-Krongrad A., Shulman G.I., Neel B.G., Kahn B.B. Mol. Cell. Biol. 20:2000;5479.
8. Zinker B.A., Rondinone C.M., Trevillyan J.M., Gum R.J., Clampit J.E., Waring J.F., Xie N., Wilcox D., Jacobson P., Frost L., Kroeger P.E., Reilly R.M., Koterski S., Opgenorth T.J., Ulrich R.G., Crosby S., Butler M., Murray S.F., McKay R.A., Bhanot S., Monia B.P., Jirousek M.R. PNAS. 99:2002;11357.
9. Taing M., Keng Y.-F., Shen K., Wu L., Lawrence D.S., Zhang Z.-Y. Biochemistry. 38:1999;2793.
10. Andersen H.S., Iversen L.F., Jeppesen C.B., Branner S., Norris K., Rasmussen H.B., Moller K.B., Møller N.P. J. Biol. Chem. 275:2000;7101.
11. Bleasdale J.E., Ogg D., Palazuk B.J., Jacob C.S., Swanson M.L., Wang X.Y., Thompson D.P., Conradi R.A., Mathews W.R., Laborde A.L., Stuchly C.W., Heijbel A., Bergdahl K., Bannow C.A., Smith C.W., Svensson C., Liljebris C., Schostarez H.J., May P.D., Stevens F.C., Larsen S.D. Biochemistry. 40:2001;5642.
12. Kotoris C.C., Chen M.J., Taylor S.D. Bioorg. Med. Chem. Lett. 8:1998;3275.
13. Larsen S.D., Barf T., Liljebris C., May P.D., Ogg D., O'Sullivan T.J., Palazuk B.J., Schostarez H.J., Stevens F.C., Bleasdale J.E. J. Med. Chem. 45:2002;598.
14. Taylor S.D., Kotoris C.C., Dinaut A.N., Wang Q., Ramachandran C., Huang Z. Bioorg. Med. Chem. Lett. 6:1998;1457.
15. Wang Q., Huang Z., Ramachandran C., Dinaut A.N., Taylor S.D. Bioorg. Med. Chem. Lett. 8:1998;345.
16. Wrobel J., Sredy J., Moxham C., Dietrich A., Li Z., Sawicki D.R., Seestaller L., Wu L., Katz A., Sullivan D., Tio C., Zhang Z.-Y. J. Med. Chem. 42:1999;3199.
17. Xian M., Wang K., Chen X., Hou Y., McGill A., Chen X., Zhou B., Zhang Z.-Y., Cheng J.-P., Wang P.G. Biochem. Biophys. Res. Commun. 268:2000;310.
18. Wrobel J., Li Z., Sredy J., Sawicki D.R., Seestaller L., Sullivan D. Bioorg. Med. Chem. Lett. 10:2000;1535.
19. Burke T.R.J., Kole H.K., Roller P.P. Biochem. Biophys. Res. Commun. 204:1994;129.
20. Desmarais S., Wang Q., Ly H., Scheigetz J., Govindarajan A., Ramachandran C., Zamboni R., Huang Z. J. Biomolecular Screening. 4:1999;327.
21. Asante-Appiah E., Ball K., Bateman K., Skorey K., Friesen R., Desponts C., Payette P., Bayly C., Zamboni R., Scapin G., Ramachandran C., Kennedy B.P. J. Biol. Chem. 276:2001;26036.
22. Desmarais S., Friesen R.W., Zamboni R., Ramachandran C. Biochem. J. 337:1999;219.
23. Skorey K.I., Kennedy B.P., Friesen R.W., Ramachandran C. Anal. Biochem. 291:2001;269.
24. Asante-Appiah E., Patel S., Dufresne C., Roy P., Wang Q., Patel V., Friesen R.W., Ramachandran C., Becker J.W., Leblanc Y., Kennedy B.P., Scapin G. Biochem. 41:2002;9043.
25. Unpublished results.
26. Cromish W.A., Payette P., Kennedy B. Biochem. Pharmacology. 58:1999;1539.
27. Coleman D.L., Hummel K.P. Diabetologia. 3:1967;238.
28. Peterson R.G., Shaw W.N., Neel M., Little L.A., Eichberg J. Inst. Lab. Animal Res. News. 32:1990;16.
29. Lau, C. K.; Bayly, C. I.; Gauthier, J. Y.; Li, C. S.; Therien, M.; Asante-Appiah, E.; Cromlish, W.; Boie, Y.; Forghani, F.; Desmarais, S.; Wang, Q.; Skorey, K.; Waddleton, D.; Payette, P.; Ramachandran, C.; Kennedy, B. P.; Scapin, G. Bioorg. Med. Chem. Lett. 2004, 14, following paper in this issue. doi:10.1016/j.bmcl.2003.11.076.