Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 4, 2004, Pages 1043-1048

  Lau, Cheuk K ^a   Bayly, Christopher I ^a   Gauthier, Jacques Yves ^a   Li, Chun Sing ^a   Therien, Michel ^a   Asante Appiah, Ernest ^a   Cromlish, Wanda ^a   Boie, Yves ^a   Forghani, Farnaz ^a   Desmarais, Sylvie ^a   Wang, Qingping ^a   Skorey, Kathryn ^a   Waddleton, Deena ^a   Payette, Paul ^a   Ramachandran, Chidambaram ^a   Kennedy, Brian P ^a   Scapin, Giovana ^b  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE; X RAY CRYSTALLOGRAPHY;

EID: 10744228071     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.076     Document Type: Article

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