Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy

Journal of the American Chemical Society

Volumn 125, Issue 14, 2003, Pages 4087-4096

  Szczepankiewicz, Bruce G ^a   Liu, Gang ^a   Hajduk, Philip J ^a   Abad Zapatero, Cele ^a   Pei, Zhonghua ^a   Xin, Zhili ^a   Lubben, Thomas H ^a   Trevillyan, James M ^a   Stashko, Michael A ^a   Ballaron, Stephen J ^a   Liang, Heng ^a   Huang, Flora ^a   Hutchins, Charles W ^a   Fesik, Stephen W ^a   Jirousek, Michael R ^b  

^a ABBOTT LABORATORIES   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; INSULIN; MOLECULAR BIOLOGY; NUCLEAR MAGNETIC RESONANCE; PROTEINS;

INSULIN RECEPTORS;

ENZYME INHIBITION;

INSULIN RECEPTOR; PROTEIN TYROSINE PHOSPHATASE INHIBITOR;

ARTICLE; CELL FUNCTION; COMPETITIVE INHIBITION; DRUG DESIGN; DRUG POTENCY; ENZYME CONFORMATION; ENZYME INHIBITION; HALF LIFE TIME; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION;

AMINO ACID SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; CATALYSIS; DRUG DESIGN; ENZYME INHIBITORS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXAMIC ACID; PROTEIN CONFORMATION; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0242417581     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0296733     Document Type: Article

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