PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 17, 2002, Pages 11357-11362

  Zinker, Bradley A ^a   Rondinone, Cristina M ^a   Trevillyan, James M ^a   Gum, Rebecca J ^a   Clampit, Jill E ^a   Waring, Jeffrey F ^a   Xie, Nancy ^a   Wilcox, Denise ^a   Jacobson, Peer ^a   Frost, Leigh ^a   Kroeger, Paul E ^a   Reilly, Regina M ^a   Koterski, Sandra ^a   Opgenorth, Terry J ^a   Ulrich, Roger G ^a   Crosby, Seth ^a   Butler, Madeline ^a   Murray, Susan F ^a   McKay, Robert A ^a   Bhanot, Sanjay ^a   Monia, Brett P ^a   Jirousek, Michael R ^a   more..

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FRUCTOSE BISPHOSPHATASE; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN KINASE B; PROTEIN P50; PROTEIN P85; PROTEIN TYROSINE PHOSPHATASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; EPIDIDYMIS FAT; GLUCOSE BLOOD LEVEL; HYPERINSULINEMIA; INSULIN SENSITIVITY; LIVER WEIGHT; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ADIPOSE TISSUE; ANIMALS; BASE SEQUENCE; BLOOD GLUCOSE; CROSSES, GENETIC; DIABETES MELLITUS; GLUCOSE TOLERANCE TEST; INSULIN; LIVER; MICE; MICE, OBESE; OBESITY; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; ORGAN SIZE; PROTEIN-TYROSINE-PHOSPHATASE; REFERENCE VALUES; RNA, COMPLEMENTARY;

ANIMALIA;

EID: 0037143754     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.142298199     Document Type: Article

References (34)