Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics

Journal of Medicinal Chemistry

Volumn 44, Issue 26, 2001, Pages 4584-4594

  Jia, Z ^a   Ye, Q ^a   Dinaut, A N ^b   Wang, Q ^c   Waddleton, D ^c   Payette, P ^c   Ramachandran, C ^c   Kennedy, B ^c   Hum, G ^b   Taylor, S D ^b  

^a QUEEN S UNIVERSITY   (Canada)

^b UNIVERSITY OF WATERLOO   (Canada)

^c MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DEPHOSPHORYLATION; DRUG BINDING SITE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; INSULIN SENSITIVITY; SIGNAL TRANSDUCTION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PHOSPHONIC ACIDS; PHOSPHOTYROSINE; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035924182     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010266w     Document Type: Article

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