Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: Identification of a tetrazole-containing inhibitor with cellular activity

Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2002, Pages 1785-1798

  Liljebris, Charlotta ^a   Larsen, Scott D ^b   Ogg, Derek ^c   Palazuk, Barbara J ^b   Bleasdale, John E ^b  

^a Biovitrum AB   (Sweden)

^b PFIZER INC   (United States)

^c Departments of Medicinal Chemistry and Structural Chemistry   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [2 [[2 [(TERT BUTOXYCARBONYL)AMINO] 3 PHENYLPROPANOYL]AMINO] 3 OXO 3 (PENTYLAMINO)PROPYL] 2 [1(2)H TETRAZOL 5 YL]PHENOXY]ACETIC ACID; CARBOXYL GROUP; DEOXYGLUCOSE; DICARBOXYLIC ACID DERIVATIVE; INSULIN; INSULIN RECEPTOR; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; TETRAZOLE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PHOSPHORYLATION;

BINDING, COMPETITIVE; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CRYSTALLOGRAPHY, X-RAY; DEOXYGLUCOSE; ENZYME INHIBITORS; HUMANS; INSULIN RESISTANCE; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES; PROPIONIC ACIDS; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 0037171833     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011100y     Document Type: Article

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