Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

Journal of Medicinal Chemistry

Volumn 43, Issue 7, 2000, Pages 1293-1310

  Malamas, Michael S ^a   Sredy, Janet ^a,b   Moxham, Christopher ^a   Katz, Alan ^a   Xu, Weixin ^a   McDevitt, Robert ^a   Adebayo, Folake O ^a   Sawicki, Diane R ^a,b   Seestaller, Laura ^a   Sullivan, Donald ^a   Taylor, Joseph R ^a  

^a PFIZER INC   (United States)

^b The Institute for Diabetes Discovery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (2 BENZYLBENZOFURAN 3 YL) BIPHENYL 4 YLOXY] 3 PHENYLPROPIONIC ACID; ANTIDIABETIC AGENT; BENZOFURAN DERIVATIVE; BENZOTHIOPHENE DERIVATIVE; BIPHENYL DERIVATIVE; GLYOXYLIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CRYSTALLOGRAPHY; DRUG ACTIVITY; DRUG DESIGN; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; GLUCOSE BLOOD LEVEL; HYDROPHOBICITY; INSULIN RESISTANCE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BENZOFURANS; BLOOD GLUCOSE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; HYPOGLYCEMIC AGENTS; MICE; MODELS, MOLECULAR; PHENYLPROPIONATES; PROTEIN-TYROSINE-PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 0034611597     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990560c     Document Type: Article

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