Expression of natural peptide antibiotics in human skin

Lancet

Volumn 350, Issue 9093, 1997, Pages 1750-1751

  Fulton, Clare ^b   Anderson, G Mark ^b   Zasloff, Michael ^b   Bull, Richard ^b   Quinn, Anthony G ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b Genaera Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN; MESSENGER RNA; POLYPEPTIDE ANTIBIOTIC AGENT;

ARTICLE; HUMAN; IN SITU HYBRIDIZATION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; SKIN INFECTION; WOUND HEALING;

EID: 0031581544     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)63574-X     Document Type: Article

References (5)

1. Kagan BL, Ganz T, Lehrer RI. Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology 1994; 87: 131-49.
2. Zhao C, Wang I, Lehrer RI. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 1996; 396: 319-22.
3. Schonwetter BS, Stolzenberg ED, Zasloff MA. Epithelial antibiotics induced at sites of inflammation. Science 1995; 267: 1645-48.
4. Frohm M, Agerberh B, Ahangari G, et al. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 1997; 272: 15258-63.
5. Harder J, Bartels J, Christophers E, Scroder JM. A peptide antibiotic from human skin. Nature 1997; 387: 861.